The effect of genetic complementation on the fitness and diversity of viruses spreading as collective infectious units

2019 ◽  
Vol 267 ◽  
pp. 41-48 ◽  
Author(s):  
Ernesto Segredo-Otero ◽  
Rafael Sanjuán
Keyword(s):  
Genetic Complementation

Genetic complementation by cloned bacteriophage T4 late genes.

1981 ◽  
Vol 39 (1) ◽  
pp. 31-45 ◽  
Author(s):  
K A Jacobs ◽  
L M Albright ◽  
D K Shibata ◽  
E P Geiduschek
Keyword(s):  
Bacteriophage T4 ◽  
Genetic Complementation ◽  
Late Genes

scholarly journals MOLECULAR GENETIC ANALYSIS OF THE DILUTE-SHORT EAR (d-se) REGION OF THE MOUSE

Genetics ◽  
1986 ◽  
Vol 112 (2) ◽  
pp. 321-342
Author(s):  
Eugene M Rinchik ◽  
Liane B Russell ◽  
Neal G Copeland ◽  
Nancy A Jenkins
Keyword(s):  
Physical Map ◽  
Leukemia Virus ◽  
Molecular Genetic ◽  
Break Point ◽  
Virus Genome ◽  
Molecular Genetic Analysis ◽  
Chromosome 9 ◽  
Genetic Complementation ◽  
Induced Mutations ◽  
Radiation Induced

ABSTRACT Genes of the dilute-short ear (d-se) region of mouse chromosome 9 comprise an array of loci important to the normal development of the animal. Over 200 spontaneous, chemically induced and radiation-induced mutations at these loci have been identified, making it one of the most genetically well-characterized regions of the mouse. Molecular analysis of this region has recently become feasible by the identification of a dilute mutation that was induced by integration of an ecotropic murine leukemia virus genome. Several unique sequence cellular DNA probes flanking this provirus have now been identified and used to investigate the organization of wild-type chromosomes and chromosomes with radiation-induced d-se region mutations. As expected, several of these mutations are associated with deletions, and, in general, the molecular and genetic complementation maps of these mutants are concordant. Furthermore, a deletion break-point fusion fragment has been identified and has been used to orient the physical map of the d-se region with respect to the genetic complementation map. These experiments provide important initial steps for analyzing this developmentally important region at the molecular level, as well as for studying in detail how a diverse group of mutagens acts on the mammalian germline.

scholarly journals Molecular and genetic analysis of the yeast early meiotic recombination genes REC102 and REC107/MER2.

1992 ◽  
Vol 12 (3) ◽  
pp. 1248-1256 ◽  
Author(s):  
M Cool ◽  
R E Malone
Keyword(s):  
Sequence Analysis ◽  
Genetic Analysis ◽  
Meiotic Recombination ◽  
Genetic Recombination ◽  
Recombination Process ◽  
Genetic Complementation ◽  
Rec Genes ◽  
Reductional Division

By selecting for mutations which could rescue the meiotic lethality of a rad52 spo13 strain, we isolated several new Rec genes required relatively early in the meiotic recombination process. This paper presents data to confirm that two of them, REC102 and REC107, are general, meiosis-specific recombination genes that have no detectable role during mitosis. Sequence analysis and genetic complementation indicate that REC107 is identical to the MER2 gene. No sequences related to REC102 have been found in the GenBank or EMBL collections. REC102 is expressed only in meiosis, prior to the reductional division, at about the time that genetic recombination occurs. Examination of the REC102 sequence indicates the presence of several sequences which may play a role in the regulation of its expression; however, the URS1 sequence commonly found in genes expressed early in meiosis is not present.

Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency

2012 ◽  
Vol 7 (4) ◽  
pp. 729-748 ◽  
Author(s):  
Dung-Fang Lee ◽  
Jie Su ◽  
Ana Sevilla ◽  
Julian Gingold ◽  
Christoph Schaniel ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Genetic Complementation ◽  
Self Renewal ◽  
Competition Assays

Identification of a sporozoite-specific member of the Toxoplasma SAG superfamily via genetic complementation

2004 ◽  
Vol 52 (1) ◽  
pp. 93-105 ◽  
Author(s):  
Jay R. Radke ◽  
Marc-Jan Gubbels ◽  
Maria E. Jerome ◽  
Joshua B. Radke ◽  
Boris Striepen ◽  
...  
Keyword(s):  
Genetic Complementation

Genetic Complementation Analysis of Xeroderma Pigmentosum

1975 ◽  
pp. 725-728 ◽  
Author(s):  
D. Bootsma ◽  
E. A. De Weerd-Kastelein ◽  
W. J. Kleijer ◽  
W. Keÿzez
Keyword(s):  
Xeroderma Pigmentosum ◽  
Complementation Analysis ◽  
Genetic Complementation

Rediscovery and further characterization of the aeroplane (ae) wing posture mutation in Drosophila melanogaster

Genome ◽  
1999 ◽  
Vol 42 (3) ◽  
pp. 403-411 ◽  
Author(s):  
Kelly H Soanes ◽  
John B Bell
Keyword(s):  
Drosophila Melanogaster ◽  
Spontaneous Mutation ◽  
Genetic Complementation ◽  
Homeotic Gene ◽  
Classical Genetic ◽  
Direct Flight ◽  
Transformation Experiment ◽  
Flight Muscles

In 1931, Theodore Quelprud characterized a novel spontaneous mutation in Drosophila melanogaster, which was named aeroplane (ae) based on its abnormal wing posture. Although the characterization of the original ae locus was minimal, it is very likely that another allele of this extinct mutation has now been identified. aeroplane-like (ae-l) was isolated as a by-product of a transformation experiment. The apparent wing paralysis is not caused by any obvious abnormalities in the thorax, wing, indirect flight muscles or direct flight muscles. Classical genetic complementation analyses of ae-l with other genes in the region suggest that it represents an allele of a novel locus. Unexpectedly, a molecular examination revealed that the physical lesion identified in the ae-l mutant is exceptionally close to the homeotic gene teashirt (tsh) and, indeed, may represent an unusual allele of teashirt.Key words: aeroplane, teashirt, wing posture, Drosophila, flight.

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