Left Frontal Meningioangiomatosis Associated with Type IIIc Focal Cortical Dysplasia Causing Refractory Epilepsy and Literature Review

Focal cortical dysplasia (FCD) is a congenital developmental anomaly that is one of the leading causes of refractory epilepsy. MRI is an essential examination and T1WI, T2WI, and FLAIR images are commonly used MR sequences for delineating FCD.1 However, these MRI findings are often insufficiently clear. We experienced two FCD cases that were much better visualized by using T1WI with chemical shift selective (CHESS) than with T2WI and FLAIR images. CHESS is the most frequently used fat suppression pulse in clinical practice. We report two cases in which CHESS clearly demonstrated FCD, and compare the cases' pathology and MRI findings.

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ILAE focal cortical dysplasia type IIIc in the ictal onset zone in epileptic patients with solitary meningioangiomatosis

Epileptic Disorders ◽

10.1684/epd.2014.0695 ◽

2014 ◽

Vol 16 (4) ◽

pp. 533-539 ◽

Cited By ~ 2

Author(s):

Nobutaka Mukae ◽

Satoshi O Suzuki ◽

Takato Morioka ◽

Nobuya Murakami ◽

Kimiaki Hashiguchi ◽

...

Keyword(s):

Focal Cortical Dysplasia ◽

Cortical Dysplasia ◽

Epileptic Patients ◽

Type Iiic

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Induced pluripotent stem cells from patients with focal cortical dysplasia and refractory epilepsy

Molecular Medicine Reports ◽

10.3892/mmr.2017.6264 ◽

2017 ◽

Vol 15 (4) ◽

pp. 2049-2056 ◽

Cited By ~ 9

Author(s):

Daniel Rodrigo Marinowic ◽

Fernanda Majolo ◽

Alessandra Deise Sebben ◽

Vinicius Duval Da Silva ◽

Tiago Giuliani Lopes ◽

...

Keyword(s):

Stem Cells ◽

Induced Pluripotent Stem Cells ◽

Pluripotent Stem Cells ◽

Refractory Epilepsy ◽

Focal Cortical Dysplasia ◽

Cortical Dysplasia ◽

Induced Pluripotent

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Similar PDK1–AKT–mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy

Epilepsy Research ◽

10.1016/j.eplepsyres.2015.02.002 ◽

2015 ◽

Vol 112 ◽

pp. 137-149 ◽

Cited By ~ 6

Author(s):

Yuan-xiang Lin ◽

Kun Lin ◽

De-zhi Kang ◽

Xin-xiu Liu ◽

Xing-fu Wang ◽

...

Keyword(s):

Refractory Epilepsy ◽

Focal Cortical Dysplasia ◽

Cortical Dysplasia ◽

Mtor Pathway ◽

Type Ii ◽

Balloon Cells ◽

Pathway Activation ◽

Dysmorphic Neurons

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On The Use of Machine Learning Algorithms to Classify Focal Cortical Dysplasia on MRI

10.5753/sbcas.2021.16063 ◽

2021 ◽

Author(s):

João Guilherme Pereira ◽

Matheus de Freitas Oliveira Baffa ◽

Fabrício Henrique Simozo ◽

Luiz Otavio Murta Junior ◽

Joaquim Cezar Felipe

Keyword(s):

Deep Neural Network ◽

Surgical Intervention ◽

Refractory Epilepsy ◽

Focal Cortical Dysplasia ◽

Cortical Dysplasia ◽

Machine Learning Algorithms ◽

Textural Features ◽

Epileptogenic Zone ◽

Neural Network Classifier ◽

Multiple Classifiers

Refractory epilepsy is a condition characterized by epileptic seizure occurrence which cannot be controlled with antiepileptic drugs. This condition is associated with an excessive neuronal discharge produced by a group of neurons in a certain epileptogenic zone. Focal Cortical Dysplasia (FCD), usually found in these zones, was detected as one of the main causes of refractory epilepsy. In these cases, surgical intervention is necessary to minimize or eliminate the seizure occurrences. However, surgical treatment is only indicated in cases where there is complete certainty of the FCD. In order to assist neurosurgeons to detect precisely these regions, this paper aims to develop a classiﬁcation method to detect FCD on MRI based on morphological and textural features from a voxel-level perspective. Multiple classiﬁers were tested throughout the extracted features, the best results achieved an accuracy of 91.76% using a Deep Neural Network classiﬁer and 96.15% with J48 Decision Tree. The set of evaluating metrics showed that the results are promising.

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