A Comparative Study of Bolus Dose of Hypertonic Saline, Mannitol, and Mannitol Plus Glycerol Combination in Patients with Severe Traumatic Brain Injury

2019 ◽  
Vol 125 ◽  
pp. e221-e228 ◽  
Author(s):  
Harshad Patil ◽  
Rakesh Gupta
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Comparative Study ◽  
Hypertonic Saline ◽  
Severe Traumatic Brain Injury ◽  
Bolus Dose

23.4% Hypertonic Saline and Intracranial Pressure in Severe Traumatic Brain Injury Among Children

2019 ◽  
Vol 20 (5) ◽  
pp. 466-473 ◽  
Author(s):  
Andrew G. Wu ◽  
Uzma Samadani ◽  
Tina M. Slusher ◽  
Lei Zhang ◽  
Andrew W. Kiragu
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Intracranial Pressure ◽  
Hypertonic Saline ◽  
Severe Traumatic Brain Injury

scholarly journals Sugar or salt (“SOS”): A protocol for a UK multicentre randomised trial of mannitol and hypertonic saline in severe traumatic brain injury and intracranial hypertension

2020 ◽  
pp. 175114372090169
Author(s):  
MJ Rowland ◽  
T Veenith ◽  
C Scomparin ◽  
MH Wilson ◽  
PJ Hutchinson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Cost Effectiveness ◽  
Brain Injury ◽  
Intracranial Pressure ◽  
Hypertonic Saline ◽  
Severe Traumatic Brain Injury ◽  
Randomised Trial ◽  
Pragmatic Trial ◽  
Open Label ◽  
The Impact

Hyperosmolar solutions are widely used to treat raised intracranial pressure following severe traumatic brain injury. Although mannitol has historically been the most frequently administered, hypertonic saline solutions are increasingly being used. However, definitive evidence regarding their comparative effectiveness is lacking. The Sugar or Salt Trial is a UK randomised, allocation concealed open label multicentre pragmatic trial designed to determine the clinical and cost-effectiveness of hypertonic saline compared with mannitol in the management of patients with severe traumatic brain injury. Patients requiring intensive care unit admission and intracranial pressure monitoring post-traumatic brain injury will be allocated at random to receive equi-osmolar boluses of either mannitol or hypertonic saline following failure of routine first-line measures to control intracranial pressure. The primary outcome for the study will be the Extended Glasgow Outcome Scale assessed at six months after randomisation. Results will inform current clinical practice in the routine use of hyperosmolar therapy as well as assess the impact of potential side effects. Pre-planned longer term clinical and cost effectiveness analyses will further inform the use of these treatments.

scholarly journals SGEM Hot Off the Press: hypertonic saline in severe traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials

CJEM ◽  
2016 ◽  
Vol 18 (5) ◽  
pp. 379-384 ◽  
Author(s):  
Eve Purdy ◽  
Brent Thoma ◽  
Ken Milne ◽  
Chris Bond
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Emergency Medicine ◽  
Social Media ◽  
Brain Injury ◽  
Hypertonic Saline ◽  
Severe Traumatic Brain Injury ◽  
Original Research ◽  
The Press ◽  
The Sgem

AbstractAs part of the Canadian Journal of Emergency Medicine’s (CJEM) developing social media strategy,1 we are collaborating with the Skeptics’ Guide to Emergency Medicine (SGEM) to summarize and critically appraise the current emergency medicine (EM) literature using evidence-based medicine principles. In the “Hot Off the Press” series, we select original research manuscripts published in CJEM to be featured on the SGEM website/podcast and discussed by the study authors and the online EM community. A similar collaboration is under way between the SGEM and Academic Emergency Medicine. What follows is a summary of the selected article, the immediate post-publication synthesis from the SGEM podcast, commentary by the first author, and the subsequent discussion from the SGEM blog and other social media. Through this series, we hope to enhance the value, accessibility, and application of important, clinically relevant EM research. In this, the second SGEM HOP hosted collaboratively with CJEM, we discuss a systematic review evaluating the use of hypertonic saline in the treatment of severe traumatic brain injury.2

scholarly journals Hypertonic saline in severe traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials – ERRATUM

CJEM ◽  
2016 ◽  
Vol 18 (3) ◽  
pp. 243-243 ◽  
Author(s):  
Elyse Berger-Pelletier ◽  
Marcel Émond ◽  
François Lauzier ◽  
Jean-François Shields ◽  
Alexis F. Turgeon
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Randomized Controlled Trials ◽  
Hypertonic Saline ◽  
Severe Traumatic Brain Injury ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled
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