High-Sensitivity C-Reactive Protein (hS-CRP) levels and pregnancy outcomes in women with unexplained infertility after ovarian stimulation with intrauterine-insemination (OS-IUI) in a multi-center trial

Background: Obesity is a chronic inflammatory condition associated with increased circulating levels of C-reactive protein (CRP). Bariatric surgery has been reported to be effective in improving both inflammatory and liver status. Our aims were to elucidate the relationships between pre-surgery high sensitivity-CRP (hs-CRP) values and post-surgery weight loss and liver steatosis and fibrosis in patients with severe obesity undergoing Roux-en-Y gastric bypass. Methods: We conducted an observational prospective study on 90 individuals with morbid obesity, who underwent gastric bypass. Anthropometric indices, laboratory assessment (lipid panel, glycemic status, liver enzymes, and hs-CRP), liver stiffness and steatosis were evaluated at baseline and 6-months after surgery. Results: There was a significant post-surgery reduction in all the anthropometric variables, with an average weight loss of 33.93 ± 11.79 kg; the mean percentage of total weight loss (TWL) was 27.96 ± 6.43%. Liver elasticity was significantly reduced (from 6.1 ± 1.25 to 5.42 ± 1.52 kPa; p = 0.002), as well as liver aminotransferases, nonalcoholic fatty liver disease fibrosis score (NFS) and the grade of steatosis. Serum hs-CRP levels significantly reduced (from 9.26 ± 8.45 to 3.29 ± 4.41 mg/L; p < 0.001). The correlations between hs-CRP levels and liver fibrosis (elastography), steatosis (ultrasonography), fibrosis-4 index, NFS, and surgery success rate were not significant. Regression analyses showed that serum hs-CRP levels were not predictive of liver status and success rate after surgery in both unadjusted and adjusted models. Conclusions: In patients with morbid obesity, bariatric surgery caused a significant decrease in hs-CRP levels, liver stiffness and steatosis. Baseline hs-CRP values did not predict the weight-loss success rate and post-surgery liver status.

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Colchicine effectively attenuates inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) in patients with non-ST-segment elevation myocardial infarction: a randomised, double-blind, placebo-controlled clinical trial

Inflammopharmacology ◽

10.1007/s10787-021-00865-0 ◽

2021 ◽

Vol 29 (5) ◽

pp. 1379-1387

Author(s):

Arash Gholoobi ◽

Vahid Reza Askari ◽

Hossein Naghedinia ◽

Mostafa Ahmadi ◽

Vida Vakili ◽

...

Keyword(s):

High Sensitivity ◽

Controlled Clinical Trial ◽

C Reactive Protein ◽

Double Blind ◽

Inflammatory Biomarker ◽

St Segment Elevation ◽

Reactive Protein ◽

Segment Elevation Myocardial Infarction ◽

St Segment ◽

Hs Crp

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Relationship Between High Sensitivity C-reactive Protein and CagA Positive Helicobacter pylori in Cardiac Syndrome X

Journal of Scientific Research ◽

10.3329/jsr.v5i3.14171 ◽

2013 ◽

Vol 5 (3) ◽

pp. 527-533

Author(s):

Y. Rasmi ◽

M. H. Seyed-Mohammadzad ◽

S. Raeisi

Keyword(s):

High Sensitivity ◽

Syndrome X ◽

C Reactive Protein ◽

Cardiac Syndrome X ◽

Elisa Method ◽

Reactive Protein ◽

Cardiac Syndrome ◽

Cytotoxin Associated Gene A ◽

Hs Crp ◽

Caga Status

Cytotoxin-associated gene A (CagA) may induce a persistent systemic inflammatory response in cardiac syndrome X (CSX). We aimed to evaluate relationship of CagA status and high sensitivity C-reactive protein (hs-CRP) in CSX patients. Sixty CSX patients and 60 gender matched controls were enrolled. Plasma samples were tested in terms of the presence of IgG antibody to Helicobacterpylori (anti-H. pylori) and CagA (anti-CagA) using ELISA method. Also, plasma level of hs-CRP was measured by ELISA method. CSX patients were detected to have significantly higher plasma hs-CRP level in comparison with the control ones (3.64 ± 3.07 vs. 0.54 ± 0.49, µg/ml, P = 0.0001). Plasma levels of hs-CRP in CSX patients with anti-CagA+ were significantly higher than those in anti-CagA(-) (CSX: 4.66±3.63 vs. 2.58±1.95 µg/ml, P = 0.011). Also, plasma levels of hs-CRP in the controls with anti-CagA+ were significantly higher than those in anti-CagA- (1.05±0.68 vs. 0.32±0.31 µg/ml, respectively, P = 0.004). The present data suggested that CagA status was probably associated with susceptibility to severe CSX by causing inflammation. The evidence for this hypothesis indicated that levels of hs-CRP increased in anti-CagA+ patients compared to the anti-CagA- ones. Keywords: Cardiac syndrome X; Helicobacter pylori; Inflammation ; hs-CRP, Cytotoxin-associated gene A. © 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi: http://dx.doi.org/10.3329/jsr.v5i3.14171 J. Sci. Res. 5 (3), 527-533 (2013)

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High-sensitivity c-reactive protein (hs-CRP) value with 90 days mortality in patients with heart failure

IOP Conference Series Earth and Environmental Science ◽

10.1088/1755-1315/125/1/012124 ◽

2018 ◽

Vol 125 ◽

pp. 012124 ◽

Cited By ~ 1

Author(s):

Nursyamsiah ◽

R Hasan

Keyword(s):

Heart Failure ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Patients With Heart Failure ◽

Hs Crp

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Abstract 18759: N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity C-Reactive Protein and Infarct Size Measured With Delayed Enhancement Multidetector Computed Tomography

Circulation ◽

10.1161/circ.130.suppl_2.18759 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Doo Sun Sim ◽

Youngkeun Ahn ◽

Yun Hyeon Kim ◽

Hyun Ju Seon ◽

Keun Ho Park ◽

...

Keyword(s):

Infarct Size ◽

High Sensitivity ◽

Lv Function ◽

C Reactive Protein ◽

Reactive Protein ◽

Lv Dysfunction ◽

Lv Remodeling ◽

Acute Mi ◽

Lv Ejection Fraction ◽

Hs Crp

Background: There is a paucity of information on the time-dependent relationship of cardiac biomarkers to infarct size and left ventricular (LV) remodeling after myocardial infarction (MI). We sought to investigate the relationship between levels high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and indices of infarct size and LV volume after acute MI. Methods: A total of 86 patients with ST-elevation MI within 12 hours after the symptom onset underwent delayed enhancement multi-detector computed tomography (DE MDCT) immediately after percutaneous coronary intervention (PCI) to determine infarct size. LV function and remodeling were assessed by echocardiography. Hs-CRP and NT-proBNP were serially measured at admission, 24 hours, and 2 months. DE MDCT and echocardiography were repeated at 2 months after PCI. Results: Levels of both hs-CRP and NT-proBNP at 24 hours showed positive correlation with infarct size at baseline and at 2 months, and negative correlation with LV ejection fraction at baseline and at 2 months. NT-proBNP at 2 months correlated with infarct size (r=0.561, p=0.007), LV ejection fraction (r= - 0.539, p=0.010), and LV end diastolic and systolic volume indices at 2 months (r=0.796, p=0.032 and r=0.831, p=0.021, respectively). NT-proBNP was higher in patients who developed LV remodeling at 2 months: 929 pg/mL vs. 134 pg/mL, p = 0.002. In contrast, hs-CRP at 2 months showed no relationship to infarct size, LV function, or LV volumes at 2 months. Conclusions: Elevated hs-CRP during active myocardial necrosis was associated with infarct size and LV dysfunction, whereas elevated levels of NT-proBNP early and late after the onset of acute MI were both correlated with infarct size, LV dysfunction, and LV remodeling.

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Basal high-sensitivity-C-reactive protein levels in patients with spontaneous venous thromboembolism

Thrombosis and Haemostasis ◽

10.1160/th04-11-0745 ◽

2005 ◽

Vol 93 (03) ◽

pp. 488-493 ◽

Cited By ~ 23

Author(s):

Rainer Vormittag ◽

Thomas Vukovich ◽

Verena Schönauer ◽

Stephan Lehr ◽

Erich Minar ◽

...

Keyword(s):

Risk Factor ◽

Venous Thromboembolism ◽

Statistical Significance ◽

Factor V Leiden ◽

High Sensitivity ◽

Prothrombin G20210a ◽

Factor V ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

SummaryThe role of C-reactive protein (CRP) in venous thromboembolism (VTE) is still under discussion because of controversial results in the literature. Conflicting data may have partly been due to bias by exogenous factors altering CRP levels. We investigated CRP concentrations in patients with spontaneous VTE applying a study design that allowed the measurement of basal high sensitivity (hs)-CRP levels. Patients with a history of deep vein thrombosis (DVT, n=117) and pulmonary embolism (PE, n=97) were compared to healthy individuals (n=104). Hs-CRP levels (mg/dl) were significantly higher in patients (n=214, median/interquartile range: 0.171/0.082–0.366) than in controls (0.099/0.053–0.245, p=0.001). The unadjusted odds ratio (OR) for VTE per 1 mg/dl increase of CRP was 2.8 [95% confidence interval (CI): 1.1–6.8, p=0.03]. This association remained significant after adjustment for factor V Leiden, prothrombin G20210A and factor VIII activity above 230% (OR = 2.9, 95% CI [1.1–7.5]), but became remarkably attenuated and lost its statistical significance after adjustment for BMI alone (OR = 1.7 [0.7–4.0]). CRP was also not independently associated with VTE in subgroups of patients (those with DVT without symptomatic PE, those with PE and patients without established risk factor) in multiple regression analysis. In summary, we observed significantly higher basal hs-CRP levels in patients with spontaneous VTE compared to healthy controls. This association was independent of hereditary and laboratory risk factors for VTE, but lost its significance after adjustment for BMI. Increased basal CRP levels do not appear to represent an independent risk factor for VTE.

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