scholarly journals Cardiac neural crest is necessary for normal addition of the myocardium to the arterial pole from the secondary heart field

2005 ◽  
Vol 281 (1) ◽  
pp. 66-77 ◽  
Author(s):  
Karen L. Waldo ◽  
Mary R. Hutson ◽  
Harriett A. Stadt ◽  
Marzena Zdanowicz ◽  
Jaroslaw Zdanowicz ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cardiac Neural Crest ◽  
Heart Field ◽  
Secondary Heart Field

scholarly journals Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

2007 ◽  
Vol 308 (2) ◽  
pp. 421-437 ◽  
Author(s):  
Yi-Hui Chen ◽  
Mamoru Ishii ◽  
Jingjing Sun ◽  
Henry M. Sucov ◽  
Robert E. Maxson
Keyword(s):  
Neural Crest ◽  
Outflow Tract ◽  
Cardiac Neural Crest ◽  
Heart Field ◽  
Secondary Heart Field

scholarly journals Semaphorin3D regulates invasion of cardiac neural crest cells into the primary heart field

2006 ◽  
Vol 298 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Mariko Sato ◽  
Huai-Jen Tsai ◽  
H. Joseph Yost
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Cardiac Neural Crest ◽  
Heart Field

scholarly journals Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Kazuki Kodo ◽  
Shinsuke Shibata ◽  
Sachiko Miyagawa-Tomita ◽  
Sang-Ging Ong ◽  
Hiroshi Takahashi ◽  
...  
Keyword(s):  
Neural Crest ◽  
Outflow Tract ◽  
Cardiac Neural Crest ◽  
Second Heart Field ◽  
Heart Field

scholarly journals A Retinoic Acid Responsive Hoxa3 Transgene Expressed in Embryonic Pharyngeal Endoderm, Cardiac Neural Crest and a Subdomain of the Second Heart Field

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27624 ◽  
Author(s):  
Nata Y. S.-G. Diman ◽  
Sophie Remacle ◽  
Nicolas Bertrand ◽  
Jacques J. Picard ◽  
Stéphane Zaffran ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Neural Crest ◽  
Cardiac Neural Crest ◽  
Second Heart Field ◽  
Pharyngeal Endoderm ◽  
Heart Field

scholarly journals Genetic and Cellular Interaction During Cardiovascular Development Implicated in Congenital Heart Diseases

2021 ◽  
Vol 8 ◽  
Author(s):  
Kazuki Kodo ◽  
Keiko Uchida ◽  
Hiroyuki Yamagishi
Keyword(s):  
Neural Crest ◽  
Congenital Heart ◽  
Cellular Interaction ◽  
Cardiovascular Development ◽  
Cardiac Neural Crest ◽  
Second Heart Field ◽  
Genomic Architecture ◽  
Heart Field ◽  
First Heart Field ◽  
Mutation Analyses

Congenital heart disease (CHD) is the most common life-threatening congenital anomaly. CHD occurs due to defects in cardiovascular development, and the majority of CHDs are caused by a multifactorial inheritance mechanism, which refers to the interaction between genetic and environmental factors. During embryogenesis, the cardiovascular system is derived from at least four distinct cell lineages: the first heart field, second heart field, cardiac neural crest, and proepicardial organ. Understanding the genes involved in each lineage is essential to uncover the genomic architecture of CHD. Therefore, we provide an overview of recent research progress using animal models and mutation analyses to better understand the molecular mechanisms and pathways linking cardiovascular development and CHD. For example, we highlight our recent work on genes encoding three isoforms of inositol 1,4,5-trisphosphate receptors (IP3R1, 2, and 3) that regulate various vital and developmental processes, which have genetic redundancy during cardiovascular development. Specifically, IP3R1 and 2 have redundant roles in the atrioventricular cushion derived from the first heart field lineage, whereas IP3R1 and 3 exhibit redundancy in the right ventricle and the outflow tract derived from the second heart field lineage, respectively. Moreover, 22q11.2 deletion syndrome (22q11DS) is highly associated with CHD involving the outflow tract, characterized by defects of the cardiac neural crest lineage. However, our studies have shown that TBX1, a major genetic determinant of 22q11DS, was not expressed in the cardiac neural crest but rather in the second heart field, suggesting the importance of the cellular interaction between the cardiac neural crest and the second heart field. Comprehensive genetic analysis using the Japanese genome bank of CHD and mouse models revealed that a molecular regulatory network involving GATA6, FOXC1/2, TBX1, SEMA3C, and FGF8 was essential for reciprocal signaling between the cardiac neural crest and the second heart field during cardiovascular development. Elucidation of the genomic architecture of CHD using induced pluripotent stem cells and next-generation sequencing technology, in addition to genetically modified animal models and human mutation analyses, would facilitate the development of regenerative medicine and/or preventive medicine for CHD in the near future.

Coadministration of ARV (Atripla) and Topiramate disrupts quail cardiac neural crest cell migration

2021 ◽  
Author(s):  
Thabiso Tshabalala ◽  
Pilani Nkomozepi ◽  
Amadi Ogonda Ihunwo ◽  
Felix Mbajiorgu
Keyword(s):  
Cell Migration ◽  
Neural Crest ◽  
Neural Crest Cell ◽  
Cardiac Neural Crest ◽  
Neural Crest Cell Migration ◽  
Crest Cell

scholarly journals Zebrafish cardiac development requires a conserved secondary heart field

Development ◽  
2011 ◽  
Vol 138 (11) ◽  
pp. 2389-2398 ◽  
Author(s):  
D. Hami ◽  
A. C. Grimes ◽  
H.-J. Tsai ◽  
M. L. Kirby
Keyword(s):  
Cardiac Development ◽  
Heart Field ◽  
Secondary Heart Field
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