The role of targeted gene panel in pediatric drug-resistant epilepsy

2020 ◽  
Vol 106 ◽  
pp. 107003
Author(s):  
Chang-Chun Wu ◽  
Meng-Han Tsai ◽  
Yen-Ju Chu ◽  
Wen-Chin Weng ◽  
Pi-Chuan Fan ◽  
...  
2020 ◽  
pp. 088307382096693
Author(s):  
Patrick J. McDonald ◽  
Viorica Hrincu ◽  
Mary B. Connolly ◽  
Mark J. Harrison ◽  
George M. Ibrahim ◽  
...  

This qualitative study investigated factors that guide physicians’ choices for minimally invasive and neuromodulatory interventions as alternatives to conventional surgery or medical management for pediatric drug-resistant epilepsy. North American physicians were recruited to one of 4 focus groups at national conferences. Discussions were analyzed using qualitative content analysis. A pragmatic neuroethics framework was applied to interpret results. Discussions revealed 2 major thematic branches: (1) clinical decision making and (2) ethical considerations. Under clinical decision making, physicians emphasized scientific evidence and patient candidacy when assessing neurotechnologies for patients. Ongoing seizures without intervention was important for safety and neurodevelopment. Under ethical considerations, resource allocation, among other financial considerations for technology adoption, were considerable sources of pressure on decision making. Access to neurotechnology was a salient theme differentiating Canadian and American contexts. When assessing novel neurotechnological interventions for pediatric drug-resistant epilepsy, physicians balance clinical and ethical factors to guide decision making and best practice.


2018 ◽  
Vol 10 ◽  
pp. 21-24 ◽  
Author(s):  
Nilika S. Singhal ◽  
Adam L. Numis ◽  
Morgan B. Lee ◽  
Edward F. Chang ◽  
Joseph E. Sullivan ◽  
...  

2017 ◽  
Vol 136 (6) ◽  
pp. 639-644 ◽  
Author(s):  
H. A. Elkhayat ◽  
R. H. Aly ◽  
I. A. Elagouza ◽  
R. H. El-Kabarity ◽  
Y. I. Galal

2016 ◽  
Vol 363 ◽  
pp. 200-206 ◽  
Author(s):  
Hua Tao ◽  
Ligang Si ◽  
Xu Zhou ◽  
Zhou Liu ◽  
Zhonghua MA ◽  
...  

2010 ◽  
Vol 5 (1) ◽  
pp. 88
Author(s):  
J Helen Cross ◽  

The ketogenic diet has been used for the treatment of drug-resistant epilepsy in childhood for almost 100 years. This aside, it is only over the past decade that renewed interest has led to a further evidence base for efficacy, evaluation of optimal implementation and wider discussion of possible mechanisms of action. Randomised controlled data have now demonstrated the diet to be as effective as any newer anti-epileptic drug (AED) in drug-resistant epilepsy. Implementation can be challenging, and is resource-intensive, but successful use can lead to improved quality of life with most immediate side effects alleviated by dietary manipulation. However, data are still required on the choice of optimal candidates and the role of alternative diets in older children.


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