A novel reporter construct for screening small molecule inhibitors that specifically target self-renewing cancer cells

2019 ◽  
Vol 383 (2) ◽  
pp. 111551
Author(s):  
Geetha Shanmugam ◽  
Amrutha Mohan ◽  
Khushbu Kumari ◽  
Jiss Maria Louis ◽  
U. Soumya Krishnan ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Reporter Construct

scholarly journals Androstano-arylpyrimidines: Novel small molecule inhibitors of MDR1 for sensitizing multidrug-resistant breast cancer cells

2021 ◽  
Vol 156 ◽  
pp. 105587
Author(s):  
Mohana Krishna Gopisetty ◽  
Dóra Izabella Adamecz ◽  
Ferenc István Nagy ◽  
Ádám Baji ◽  
Vasiliki Lathira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Small Molecule ◽  
Breast Cancer Cells ◽  
Small Molecule Inhibitors ◽  
Multidrug Resistant

Design and synthesis of tailored human caseinolytic protease P inhibitors

2018 ◽  
Vol 54 (70) ◽  
pp. 9833-9836 ◽  
Author(s):  
Thomas F. Gronauer ◽  
Melanie M. Mandl ◽  
Markus Lakemeyer ◽  
Mathias W. Hackl ◽  
Martina Meßner ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Target Identification ◽  
Functional Studies ◽  
Design And Synthesis ◽  
Caseinolytic Protease ◽  
Complex Target

To expedite functional studies of human ClpP we introduce tailored small molecule inhibitors. These compounds are active against the proteolytic ClpXP complex. Target identification elucidates anti-proliferative effects against cancer cells.

scholarly journals Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (46) ◽  
pp. 75104-75117 ◽  
Author(s):  
Sanjeevani Arora ◽  
Joshua Heyza ◽  
Hao Zhang ◽  
Vivian Kalman-Maltese ◽  
Kristin Tillison ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cancer Cells ◽  
Small Molecule ◽  
Small Molecule Inhibitors

Structure-based Drug Design Strategies in the Development of Small Molecule Inhibitors Targeting Bcl-2 Family Proteins

2020 ◽  
Vol 17 (8) ◽  
pp. 943-953
Author(s):  
Zhe Yin ◽  
Donglin Yang ◽  
Jun Wang ◽  
Yuequan Jiang
Keyword(s):  
Clinical Trials ◽  
Drug Design ◽  
B Cell ◽  
Cancer Cells ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Design Strategies ◽  
Structure Based Drug Design

Proteins of B-cell lymphoma (Bcl-2) family are key regulators of apoptosis and are involved in the pathogenesis of various cancers. Disrupting the interactions between the antiapoptotic and proapoptotic Bcl-2 members is an attractive strategy to reactivate the apoptosis of cancer cells. Structure-based drug design (SBDD) has been successfully applied to the discovery of small molecule inhibitors targeting Bcl-2 proteins in past decades. Up to now, many Bcl-2 inhibitors with different paralogue selectivity profiles have been developed and some were used in clinical trials. This review focused on the recent applications of SBDD strategies in the development of small molecule inhibitors targeting Bcl-2 family proteins.

Small Molecule Inhibitors of Progesterone Receptor Action in Breast Cancer Cells.

2010 ◽  
pp. P1-20-P1-20
Author(s):  
IO Aninye ◽  
KC Berg ◽  
MT Cherian ◽  
AR Mollo ◽  
AL Etheridge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Small Molecule ◽  
Breast Cancer Cells ◽  
Small Molecule Inhibitors ◽  
Receptor Action

scholarly journals Multidentate Small-Molecule Inhibitors ofVacciniaH1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer Cells

2009 ◽  
Vol 52 (21) ◽  
pp. 6716-6723 ◽  
Author(s):  
Shuangding Wu ◽  
Sofie Vossius ◽  
Souad Rahmouni ◽  
Ana V. Miletic ◽  
Torkel Vang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Cervix Cancer
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