Effect of gestational diabetes mellitus and pregnancy-induced hypertension on human umbilical vein smooth muscle KATP channels

Abstract Both gestational diabetes mellitus(GDM) and pregnancy induced hypertension (PIH) would influence the gestation significantly. However, the causation between these two symptoms remains speculative. 16,404 pregnant women were identified in Harbin, China in this study. We investigated the evaluate the causal effect of GMD on PIH based on the statistic inference theory. The statistical results indicated that GDM might cause PIH. Also, this case study demonstrated that the decrease temperature might also cause hypertension during pregnancy, and the prevalence rate of GDM increased with age. However, the prevalence of diabetes did not show a remarkable difference in varied areas and ages. This study could provide some essential information that will help to investigate the mechanism for GDM and PIH.

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Exposure to environmental contaminants and risk of pregnancy induced hypertension and gestational diabetes mellitus

ISEE Conference Abstracts ◽

10.1289/isee.2020.virtual.p-0796 ◽

2020 ◽

Vol 2020 (1) ◽

Author(s):

R. Khalili ◽

V. Vieira

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Environmental Contaminants ◽

Pregnancy Induced Hypertension ◽

Induced Hypertension

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Risks for Gestational Diabetes Mellitus and Pregnancy-Induced Hypertension Are Increased in Polycystic Ovary Syndrome

BioMed Research International ◽

10.1155/2013/182582 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 14

Author(s):

Yunhui Wang ◽

Xiaomiao Zhao ◽

Huidan Zhao ◽

Hong Ding ◽

Jianping Tan ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Polycystic Ovary Syndrome ◽

Gestational Diabetes Mellitus ◽

Ovarian Stimulation ◽

Polycystic Ovary ◽

Pregnancy Induced Hypertension ◽

Ovary Syndrome ◽

Induced Hypertension ◽

Ivf Et

Objectives. To evaluate pregnancy outcomes and its determinants in women with polycystic ovary syndrome (PCOS).Methods. Two-hundred and twenty pregnant PCOS and 594 healthy women were followed from early pregnancy. Incidences of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preterm birth, twinning, and fetal growth restriction (FGR) were determined.Results. The incidence of GDM was notably higher among all PCOS combined (54.9%; OR: 2.9, 95% CI: 2.0–4.1) and PCOS subgroups, whether they conceived spontaneously (51.5%; OR: 3.3, 95% CI: 2.0–5.4), or via IVF-ET or ovarian stimulation, compared with controls (14.3%;P<0.001). The incidence of PIH was also higher among all PCOS (10.4%; OR: 2.2, 95% CI: 1.1–4.4) and the subgroup conceiving spontaneously (11.8%; OR: 2.6, 95% CI: 1.1–6.2;P<0.001) but not for those conceiving with IVF-ET (9.1%) or ovarian stimulation (9.4%). Lean women with PCOS (BMI<24kg/m2) had higher incidences of GDM (51.1% versus 14.5%; OR: 5.6, 95% CI: 3.4–9.0) and PIH (8.9% versus 3.2%; OR: 3.0, 95% CI: 1.3–7.1) than lean controls. PCOS woemn with normal glucose tolerance had higher risk for PIH than their comparable control group (OR: 4.0, 95% CI: 1.3–11.7).Conclusion. This study suggested that PCOS is an independent risk factor for the development of GDM and PIH. This trial is registered withChiCTR-RCC-11001824.

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