The IGF-1/GH-GLUTs-plasma glucose regulating axis in hybrid grouper (Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂) fed a high-carbohydrate diet

Insulin was administered intravenously with or without the concurrent infusion of glucose to dogs surgically prepared so that hepatic glucose production could be measured directly. In dogs fed a high protein diet, hepatic glucose output as directly measured did not significantly change on insulin administration. The threshold at which a net hepatic glucose uptake occurred on the administration of a glucose load was unaffected by the presence of insulin. In contrast, in dogs fed a high carbohydrate diet, on the simultaneous infusion of insulin and glucose, a net uptake of glucose by the liver occurred at lower than normal plasma glucose concentrations. Hepatic glucose production was also estimated indirectly by isotopic techniques. A brief decrease in the rate of decline of plasma glucose specific activity was observed following the injection of C14-labeled glucose and then insulin in both protein and carbohydrate-fed animals. The explanation for this phenomenon remains uncertain. It is concluded that dietary status is important in determining the action of insulin on the liver. In dogs fed a high carbohydrate diet an almost immediate and perhaps direct action of insulin on the liver appears demonstrable.

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High Carbohydrate Diet Increased Glucose Transporter Protein Levels in Jejunum but Did Not Lead to Enhanced Post-Exercise Skeletal Muscle Glycogen Recovery

Nutrients ◽

10.3390/nu13072140 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2140

Author(s):

Yumiko Takahashi ◽

Yutaka Matsunaga ◽

Hiroki Yoshida ◽

Terunaga Shinya ◽

Ryo Sakaguchi ◽

...

Keyword(s):

Skeletal Muscle ◽

Glucose Transporter ◽

High Carbohydrate Diet ◽

Oral Glucose ◽

Carbohydrate Diet ◽

Post Exercise ◽

Glucose Administration ◽

Protein Levels ◽

High Carbohydrate ◽

Glucose Transporter 2

We examined the effect of dietary carbohydrate intake on post-exercise glycogen recovery. Male Institute of Cancer Research (ICR) mice were fed moderate-carbohydrate chow (MCHO, 50%cal from carbohydrate) or high-carbohydrate chow (HCHO, 70%cal from carbohydrate) for 10 days. They then ran on a treadmill at 25 m/min for 60 min and administered an oral glucose solution (1.5 mg/g body weight). Compared to the MCHO group, the HCHO group showed significantly higher sodium-D-glucose co-transporter 1 protein levels in the brush border membrane fraction (p = 0.003) and the glucose transporter 2 level in the mucosa of jejunum (p = 0.004). At 30 min after the post-exercise glucose administration, the skeletal muscle and liver glycogen levels were not significantly different between the two diet groups. The blood glucose concentration from the portal vein (which is the entry site of nutrients from the gastrointestinal tract) was not significantly different between the groups at 15 min after the post-exercise glucose administration. There was no difference in the total or phosphorylated states of proteins related to glucose uptake and glycogen synthesis in skeletal muscle. Although the high-carbohydrate diet significantly increased glucose transporters in the jejunum, this adaptation stimulated neither glycogen recovery nor glucose absorption after the ingestion of post-exercise glucose.

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Improvement of Obesity and Dyslipidemic Activity of Amomum tsao-ko in C57BL/6 Mice Fed a High-Carbohydrate Diet

Molecules ◽

10.3390/molecules26061638 ◽

2021 ◽

Vol 26 (6) ◽

pp. 1638

Author(s):

Ju-Hyoung Park ◽

Eun-Kyung Ahn ◽

Min Hee Hwang ◽

Young Jin Park ◽

Young-Rak Cho ◽

...

Keyword(s):

Body Weight Gain ◽

Subcutaneous Fat ◽

Density Lipoprotein ◽

Ethanol Extract ◽

Cardiac Risk ◽

Normal Diet ◽

High Carbohydrate Diet ◽

Atherogenic Index ◽

Carbohydrate Diet ◽

High Carbohydrate

Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is a medicinal herb found in Southeast Asia that is used for the treatment of malaria, abdominal pain, dyspepsia, etc. The aim of this study was to investigate the effect of an ethanol extract of Amomum tsao-ko (EAT) on obesity and hyperlipidemia in C57BL/6 mice fed a high-carbohydrate diet (HCD). First, the mice were divided into five groups (n = 6/group) as follows: normal diet, HCD, and HCD+EAT (100, 200, and 400 mg/kg/day), which were orally administered with EAT daily for 84 days. Using microcomputed tomography (micro-CT) analysis, we found that EAT inhibited not only body-weight gain, but also visceral fat and subcutaneous fat accumulation. Histological analysis confirmed that EAT decreased the size of fat tissues. EAT consistently improved various indices, including plasma levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein, high-density lipoprotein, atherogenic index, and cardiac risk factors, which are related to dyslipidemia—a major risk factor for heart disease. The contents of TC and TG, as well as the lipid droplets of HCD-induced hepatic accumulation in the liver tissue, were suppressed by EAT. Taken together, these findings suggest the possibility of developing EAT as a therapeutic agent for improving HCD-induced obesity and hyperlipidemia.

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Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis

Liver International ◽

10.1111/liv.12353 ◽

2013 ◽

Vol 34 (3) ◽

pp. 427-437 ◽

Cited By ~ 28

Author(s):

Samar H. Ibrahim ◽

Gregory J. Gores ◽

Petra Hirsova ◽

Michelle Kirby ◽

Lili Miles ◽

...

Keyword(s):

High Carbohydrate Diet ◽

High Fat ◽

Carbohydrate Diet ◽

Mixed Lineage Kinase ◽

High Carbohydrate ◽

Mixed Lineage Kinase 3 ◽

Deficient Mice

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Low-fat high-carbohydrate diet and plasma sex hormones

British Journal of Cancer ◽

10.1038/bjc.1998.664 ◽

1998 ◽

Vol 78 (9) ◽

pp. 1256-1256

Author(s):

TJ Key

Keyword(s):

Sex Hormones ◽

High Carbohydrate Diet ◽

Low Fat ◽

Carbohydrate Diet ◽

High Carbohydrate

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Acute dietary PCPA treatment decreases the KD of brain [3H]5-HT binding in rainbow trout, Oncorhynchus mykiss, fed a high carbohydrate diet

Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology ◽

10.1016/1367-8280(94)90076-0 ◽

1994 ◽

Vol 107 (3) ◽

pp. 455-461 ◽

Cited By ~ 1

Author(s):

W.L. Johnston ◽

N.T. Glanville

Keyword(s):

Rainbow Trout ◽

Oncorhynchus Mykiss ◽

High Carbohydrate Diet ◽

Carbohydrate Diet ◽

High Carbohydrate ◽

Rainbow Trout Oncorhynchus Mykiss

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The Bacteriological Examinations of the Faeces in Four Cases of Typhoid Fever, made at frequent intervals for a period of one month

Journal of Hygiene ◽

10.1017/s0022172400008512 ◽

1924 ◽

Vol 23 (1) ◽

pp. 106-116 ◽

Cited By ~ 1

Author(s):

Leonard P. Lockhart

Keyword(s):

Typhoid Fever ◽

Physical State ◽

Intestinal Flora ◽

High Carbohydrate Diet ◽

The Body ◽

Causative Organism ◽

Carbohydrate Diet ◽

High Carbohydrate ◽

Large Numbers

1. The appearance and disappearance of typhoid bacilli in the faeces in these four cases bore no relation to changes in the diet nor to the physical state of the stools, but the later they appeared the shorter was the duration of their appearance.On the disappearance of typhoid bacilli from the stools the intestinal flora tended to become more simple.2. B. coli was the only organism invariably present at every examination.3. Streptococci were very much more abundant in the earlier stages of the disease, when milk formed the greater part of the diet, than in the later stages.4. In two cases where boils occurred on the body the causative organism had previously been isolated in large numbers from the faeces.5. With stools slightly alkaline to litmus the flora in these cases was relatively simple and fermentative in type. There is no apparent advantage, therefore, in giving a high carbohydrate diet except in cases of marked alkalinity and putrefaction.

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