scholarly journals The role of AT1 receptor-mediated reproductive function in renovascular hypertension in male rats

2012 ◽  
Vol 62 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Karin Viana Weissheimer ◽  
Celso Rodrigues Franci ◽  
Aldo Bolten Lucion ◽  
Gilberto Luiz Sanvitto
Keyword(s):  
Renovascular Hypertension ◽  
Reproductive Function ◽  
At1 Receptor ◽  
Male Rats

Reproductive dysfunction after mercury exposure at low levels: evidence for a role of glutathione peroxidase (GPx) 1 and GPx4 in male rats

2017 ◽  
Vol 29 (9) ◽  
pp. 1803 ◽  
Author(s):  
Caroline S. Martinez ◽  
Franck M. Peçanha ◽  
Daniela S. Brum ◽  
Francielli W. Santos ◽  
Jeferson L. Franco ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Reproductive Toxicity ◽  
Membrane Integrity ◽  
Reproductive Function ◽  
Reproductive Organs ◽  
Mercury Contamination ◽  
Male Rats ◽  
Mercury Chloride ◽  
Male Reproductive Function

Mercury is a ubiquitous environmental pollutant and mercury contamination and toxicity are serious hazards to human health. Some studies have shown that mercury impairs male reproductive function, but less is known about its effects following exposure at low doses and the possible mechanisms underlying its toxicity. Herein we show that exposure of rats to mercury chloride for 30 days (first dose 4.6 µg kg–1, subsequent doses 0.07 µg kg–1 day–1) resulted in mean (± s.e.m.) blood mercury concentrations of 6.8 ± 0.3 ng mL–1, similar to that found in human blood after occupational exposure or released from removal of amalgam fillings. Even at these low concentrations, mercury was deposited in reproductive organs (testis, epididymis and prostate), impaired sperm membrane integrity, reduced the number of mature spermatozoa and, in the testes, promoted disorganisation, empty spaces and loss of germinal epithelium. Mercury increased levels of reactive oxygen species and the expression of glutathione peroxidase (GPx) 1 and GPx4. These results suggest that the toxic effects of mercury on the male reproductive system are due to its accumulation in reproductive organs and that the glutathione system is its potential target. The data also suggest, for the first time, a possible role of the selenoproteins GPx1 and GPx4 in the reproductive toxicity of mercury chloride.

scholarly journals Effect of transplantation of muscle tissue in rats from the same litter on total number of flavins and FAD

2015 ◽  
Vol 6 (1) ◽  
pp. 28-31
Author(s):  
S. N. Kobylnik ◽  
I. L. Vovchuk ◽  
O. O. Dosenko ◽  
S. N. Kozishkurt ◽  
D. V. Morosova ◽  
...  
Keyword(s):  
Surgical Intervention ◽  
Reproductive Function ◽  
Male Rats ◽  
Acid Oxidation ◽  
Muscular Tissue ◽  
Control Parameters ◽  
Animal Tissues ◽  
Muscular Tissues

Riboflavin is a member of redox enzymes involved in fatty acid oxidation and energy generation. Important role of this vitamin is in reproductive function. Exchange of transformation of riboflavin in animal tissues and cells of microorganisms include reactions that lead to synthesis and subsequent collapse of FMN and FAD. It is involved in enhancing antitumor activity of many anticancer drugs, as well as activation of the immune system to kill tumor cells. Issues of transport of riboflavin and its derivatives in animals have been studied enough. Investigations of changes of the balance of riboflavin and its metabolites in muscular tissues before transplantation in rats from one litter and at operation without replanting were conducted, based on the Udenfriend method of flavin determination. Transplantation in the experiment was carried out on white non-linear male rats weighing 180–300 g. Animals were taken out of the experiment by passing electric current through the medulla. Belly muscular tissue was taken from donor rats of the same litter, and that tissue was sewn to homological muscular tissue of the recipient. The same procedure was carried out with femoral muscular tissue. In the course of operation without replanting the same manipulations have been made except for transplantation stage (for determination of the effect of surgical intervention). Tissue not subject to any surgical intervention served as a control. Parameters of the study were measured on the first, third and seventh days after transplantation. Transplantation of muscular tissue caused no changes in total flavin amount. Content of RF + FMN after transplantation of muscular tissue in rats of the same litter decreased in femoral muscular tissue of the recipient. Transplantation of muscular tissues in rats from the same litter lead to increase in FAD amount in femoral muscular tissue of the donor and recipient on the third day of the experiment. Transplantation of femoral muscular tissue lead to acceleration of FAD synthesis from riboflavin and FMN.

Effects of renovascular hypertension on reproductive function in male rats

Life Sciences ◽  
2007 ◽  
Vol 80 (17) ◽  
pp. 1627-1634 ◽  
Author(s):  
Márcia Koja Breigeiron ◽  
Aldo Bolten Lucion ◽  
Gilberto Luiz Sanvitto
Keyword(s):  
Renovascular Hypertension ◽  
Reproductive Function ◽  
Male Rats

Effects of paroxitine on biochemical parameters and reproductive function in male rats

2019 ◽  
Author(s):  
Rachid Mosbah ◽  
Aziz Chettoum ◽  
Zohir Djerrou ◽  
Alberto Mantovani
Keyword(s):  
Biochemical Parameters ◽  
Reproductive Function ◽  
Male Rats

Role of chromium (III) in the nutrition of pigs and cattle

2016 ◽  
Vol 3 (2) ◽  
pp. 56-62
Author(s):  
R. Iskra ◽  
V. Vlizlo ◽  
R. Fedoruk
Keyword(s):  
Growth And Development ◽  
Reproductive Function ◽  
Metabolic Effect ◽  
Considerable Part ◽  
Cultural Medium ◽  
Milk Performance ◽  
Chromium Compounds ◽  
The Impact ◽  
Different Sources

The results of our studies and the data of modern literature regarding the biological role of Cr(III) compounds in conditions of their application in the nutrition for pigs and cattle are discussed. The metabolic impact of Cr(III), coming from different sources – mineral and organic compounds, obtained by chemical synthesis or a nanotechnological method (chromium citrate), as well as in the form of biocomplexes from the cultural medium of Saccharomyces cerevisiae yeasts was analyzed. The metabolic connection between the impact of Cr(III) and the biosynthesis of some hormones – insulin, cortisol – as well as the sensitivity of some tissues and organs to the effect of chromium compounds was studied. A considerable part of the review material was dedicated to the metabolic effect of Cr(III) compounds on the reproductive function of pigs and cattle and their impact on the viability of the offspring and gametes of animals. The data about the stimulating effect of Cr(III) on the growth and development of the organism of piglets and calves, meat and milk performance of these species of animals are discussed. The relevance of dosing Cr(III) in the nutrition of pigs and cattle is highlighted.

ACE2/Angiotensin-(1-7)/Mas Receptor Axis in Human Cancer: Potential Role for Pediatric Tumors

2020 ◽  
Vol 21 (9) ◽  
pp. 892-901 ◽  
Author(s):  
Ana Luiza Ataide Carneiro de Paula Gonzaga ◽  
Vitória Andrade Palmeira ◽  
Thomas Felipe Silva Ribeiro ◽  
Larissa Braga Costa ◽  
Karla Emília de Sá Rodrigues ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Angiotensin Ii ◽  
Pediatric Cancer ◽  
Pediatric Patients ◽  
Human Cancer ◽  
Experimental Studies ◽  
At1 Receptor ◽  
Pediatric Tumors ◽  
Mas Receptor

Background: Pediatric tumors remain the highest cause of death in developed countries. Research on novel therapeutic strategies with lesser side effects is of utmost importance. In this scenario, the role of Renin-Angiotensin System (RAS) axes, the classical one formed by angiotensinconverting enzyme (ACE), Angiotensin II and AT1 receptor and the alternative axis composed by ACE2, Angiotensin-(1-7) and Mas receptor, have been investigated in cancer. Objective: This review aimed to summarize the pathophysiological role of RAS in cancer, evidence for anti-tumor effects of ACE2/Angiotensin-(1-7)/Mas receptor axis and future therapeutic perspectives for pediatric cancer. Methods: Pubmed, Scopus and Scielo were searched in regard to RAS molecules in human cancer and pediatric patients. The search terms were “RAS”, “ACE”, “Angiotensin-(1-7)”, “ACE2”, “Angiotensin II”, “AT1 receptor”, “Mas receptor”, “Pediatric”, “Cancer”. Results: Experimental studies have shown that Angiotensin-(1-7) inhibits the growth of tumor cells and reduces local inflammation and angiogenesis in several types of cancer. Clinical trials with Angiotensin-( 1-7) or TXA127, a pharmaceutical grade formulation of the naturally occurring peptide, have reported promising findings, but not enough to recommend medical use in human cancer. In regard to pediatric cancer, only three articles that marginally investigated RAS components were found and none of them evaluated molecules of the alternative RAS axis. Conclusion: Despite the potential applicability of Angiotensin-(1-7) in pediatric tumors, the role of this molecule was never tested. Further clinical trials are necessary, also including pediatric patients, to confirm safety and efficiency and to define therapeutic targets.

The Possible Role of Prolactin in the Circadian Rhythm of Leptin Secretion in Male Rats

2000 ◽  
Vol 224 (3) ◽  
pp. 152-158 ◽  
Author(s):  
C. A. Mastronardi ◽  
A. Walczewska ◽  
W. H. Yu ◽  
S. Karanth ◽  
A. F. Parlow ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Male Rats
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