Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure

2010 ◽  
Vol 48 (6) ◽  
pp. 1187-1193 ◽  
Author(s):  
Florian Weis ◽  
Andres Beiras-Fernandez ◽  
Ralf Sodian ◽  
Ingo Kaczmarek ◽  
Bruno Reichart ◽  
...  
Keyword(s):  
Heart Failure ◽  
Expression Pattern ◽  
Cannabinoid Receptor ◽  
Severe Heart Failure ◽  
Endocannabinoid System ◽  
Altered Expression ◽  
Cannabinoid Receptor 2 ◽  
Altered Expression Pattern

Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in Piriform Cortex After Seizures

2015 ◽  
Vol 53 (3) ◽  
pp. 1782-1793 ◽  
Author(s):  
Hao Wu ◽  
Chao Wang ◽  
Bei Liu ◽  
Huanfa Li ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Ion Channel ◽  
Expression Pattern ◽  
Piriform Cortex ◽  
Altered Expression ◽  
Altered Expression Pattern

scholarly journals Altered expression pattern of testican-1 mRNA after brain injury

2011 ◽  
Vol 32 (6) ◽  
pp. 373-378 ◽  
Author(s):  
Ken Iseki ◽  
Seita Hagino ◽  
Yuxiang Zhang ◽  
Tetsuji Mori ◽  
Nobuko Sato ◽  
...  
Keyword(s):  
Brain Injury ◽  
Expression Pattern ◽  
Altered Expression ◽  
Altered Expression Pattern

Altered expression pattern of SLAM family receptors on pathological B cells of patients with chronic lymphocytic leukemia

2016 ◽  
Vol 58 (7) ◽  
pp. 1726-1729 ◽  
Author(s):  
Matus Coma ◽  
Elena Tothova ◽  
Tomas Guman ◽  
Martina Hajikova ◽  
Maria Giertlova ◽  
...  
Keyword(s):  
B Cells ◽  
Chronic Lymphocytic Leukemia ◽  
Expression Pattern ◽  
Lymphocytic Leukemia ◽  
Altered Expression ◽  
Altered Expression Pattern ◽  
Slam Family

scholarly journals Expression of the endocannabinoid receptors in human fascial tissue

2016 ◽  
Author(s):  
C. Fede ◽  
G. Albertin ◽  
L. Petrelli ◽  
M.M. Sfriso ◽  
C. Biz ◽  
...  
Keyword(s):  
Cannabinoid Receptors ◽  
Cannabinoid Receptor ◽  
Endocannabinoid System ◽  
Trigger Points ◽  
Small Samples ◽  
Myofascial Trigger Points ◽  
Cannabinoid Receptor 2 ◽  
Culture Cells ◽  
Cb1 Cannabinoid Receptor ◽  
A Cell

Cannabinoid receptors have been localized in the central and peripheral nervous system as well as on cells of the immune system, but recent studies on animal tissue gave evidence for the presence of cannabinoid receptors in different types of tissues. Their presence was supposed also in myofascial tissue, suggesting that the endocannabinoid system may help resolve myofascial trigger points and relieve symptoms of fibromyalgia. However, until now the expression of CB1 (cannabinoid receptor 1) and CB2 (cannabinoid receptor 2) in fasciae has not yet been established. Small samples of fascia were collected from volunteers patients during orthopedic surgery. For each sample were done a cell isolation, immunohistochemical investigation (CB1 and CB2 antibodies) and real time RT-PCR to detect the expression of CB1 and CB2. Both cannabinoid receptors are expressed in human fascia and in human fascial fibroblasts culture cells, although to a lesser extent than the control gene. We can assume that the expression of mRNA and protein of CB1 and CB2 receptors in fascial tissue are concentrated into the fibroblasts. This is the first demonstration that the fibroblasts of the muscular fasciae express CB1 and CB2. The presence of these receptors could help to provide a description of cannabinoid receptors distribution and to better explain the role of fasciae as pain generator and the efficacy of some fascial treatments. Indeed the endocannabinoid receptors of fascial fibroblasts can contribute to modulate the fascial fibrosis and inflammation.

MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure

2014 ◽  
Vol 451 (4) ◽  
pp. 516-521 ◽  
Author(s):  
Patrick Möhnle ◽  
Stefanie Veronika Schütz ◽  
Marc Schmidt ◽  
Christian Hinske ◽  
Max Hübner ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cannabinoid Receptor ◽  
Severe Heart Failure

scholarly journals THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Amelia Dahlén ◽  
Mahdi Zarei ◽  
Adam Melgoza ◽  
Mahendra Wagle ◽  
Su Guo
Keyword(s):  
Nmda Receptor ◽  
Cannabinoid Receptor ◽  
Repetitive Behavior ◽  
Endocannabinoid System ◽  
Adult Zebrafish ◽  
Acute Effects ◽  
Cannabinoid Receptor 1 ◽  
Cannabinoid Receptor 2 ◽  
High Doses ◽  
Underlying Mechanisms

AbstractHigh doses of the Cannabis constituent Δ9-tetrahydrocannabinol (THC) increase the risk of psychosis in humans. Highly accessible animal models are needed to address underlying mechanisms. Using zebrafish with a conserved endocannabinoid system, this study investigates the acute effects of THC on adult zebrafish behavior and the mechanisms involved. A concentration-dependent THC-induced behavioral stereotypy akin to THC’s effect in rats and the psychotropics phencyclidine and ketamine in zebrafish was established. Distinctive circular swimming during THC-exposure was measured using a novel analytical method that we developed, which detected an elevated Repetition Index (RI) compared to vehicle controls. This was reduced upon co-administration of N-methyl-D-aspartate (NMDA) receptor agonist NMDA, suggesting that THC exerts its effects via biochemical or neurobiological mechanisms associated with NMDA receptor antagonism. Co-treatment of γ‐aminobutyric acid receptor antagonist pentylenetetrazol also showed signs of reducing the RI. Since THC-induced repetitive behavior remained in co-administrations with cannabinoid receptor 1 inverse agonist AM251, the phenotype may be cannabinoid receptor 1-independent. Conversely, the inverse cannabinoid receptor 2 agonist AM630 significantly reduced THC-induced behavioral stereotypy, indicating cannabinoid receptor 2 as a possible mediator. A significant reduction of the THC-RI was also observed by the antipsychotic sulpiride. Together, these findings highlight this model’s potential for elucidating the mechanistic relationship between Cannabis and psychosis.

scholarly journals Cnr2 Is Important for Ribbon Synapse Maturation and Function in Hair Cells and Photoreceptors

2021 ◽  
Vol 14 ◽  
Author(s):  
Luis Colón-Cruz ◽  
Roberto Rodriguez-Morales ◽  
Alexis Santana-Cruz ◽  
Juan Cantres-Velez ◽  
Aranza Torrado-Tapias ◽  
...  
Keyword(s):  
Hair Cells ◽  
Cannabinoid Receptor ◽  
Sensory Information ◽  
Endocannabinoid System ◽  
Cannabinoid Receptor 2 ◽  
Ribbon Synapses ◽  
Sensory Epithelia ◽  
Synapse Maturation ◽  
And Function

The role of the cannabinoid receptor 2 (CNR2) is still poorly described in sensory epithelia. We found strong cnr2 expression in hair cells (HCs) of the inner ear and the lateral line (LL), a superficial sensory structure in fish. Next, we demonstrated that sensory synapses in HCs were severely perturbed in larvae lacking cnr2. Appearance and distribution of presynaptic ribbons and calcium channels (Cav1.3) were profoundly altered in mutant animals. Clustering of membrane-associated guanylate kinase (MAGUK) in post-synaptic densities (PSDs) was also heavily affected, suggesting a role for cnr2 for maintaining the sensory synapse. Furthermore, vesicular trafficking in HCs was strongly perturbed suggesting a retrograde action of the endocannabinoid system (ECs) via cnr2 that was modulating HC mechanotransduction. We found similar perturbations in retinal ribbon synapses. Finally, we showed that larval swimming behaviors after sound and light stimulations were significantly different in mutant animals. Thus, we propose that cnr2 is critical for the processing of sensory information in the developing larva.

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