Effect of Fibrin Glue on Collagen Deposition After Autologous Fascia Grafting in Rabbit Vocal Folds

2012 ◽  
Vol 2012 ◽  
pp. 63-64
Author(s):  
R. Franco
Keyword(s):  
Fibrin Glue ◽  
Vocal Folds ◽  
Collagen Deposition

Effect of Fibrin Glue on Collagen Deposition after Autologous Fascia Grafting in Rabbit Vocal Folds

2011 ◽  
Vol 120 (10) ◽  
pp. 663-668 ◽  
Author(s):  
Fabrício Scapini ◽  
Luiz Fernando Ferraz da Silva ◽  
Domingos Hiroshi Tsuji ◽  
Marisa Dolhnikoff ◽  
Luiz Ubirajara Sennes
Keyword(s):  
Fibrin Glue ◽  
Vocal Folds ◽  
Collagen Deposition

scholarly journals Comparative study in swines' vocal cords healing after excision of fragment with CO2 laser with mitomycin and 5-fluorouracil postoperative topical application

2009 ◽  
Vol 24 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Eduardo Baptistella ◽  
Osvaldo Malafaia ◽  
Nicolau Gregori Czeczko ◽  
Jurandir Marcondes Ribas-Filho ◽  
Paulo Afonso Nunes Nassif ◽  
...  
Keyword(s):  
Comparative Study ◽  
Co2 Laser ◽  
Topical Application ◽  
Drug Application ◽  
Vocal Folds ◽  
Control Group ◽  
Collagen Deposition ◽  
Vocal Cords ◽  
The Mean ◽  
Picrosirius Red

PURPOSE: To evaluate the deposition of collagen fibers at pig's vocal folds after topical use of mitomycin or 5-fluorouracil, when partial exeresis of mucosa layer had been promoted by CO2 laser. METHODS: There were used 18 Larger white pigs which were anesthetized and submitted to mucosa fragment's exeresis, bilaterally, at its free border. The animals were divided into 3 groups, each one with 6 animals: control group, without topical drug application; mitomycin group; and 5-fluorouracil group. After 30 days, the animals were subjected to euthanasia, and samples of the vocal folds were collected and stained by picrosirius red technique with polarization for quantification of total collagen deposition. RESULTS: In control group, the mean rate of right vocal fold's collagen deposition at submucosa consisted in a 3428.66 micrometers area. There was found an area whose size had, in average, 2196.36 micrometers, in mitomycin group, and 2269.19 micrometers, in 5-fluorouracil group. CONCLUSION: Mitomycin and 5-fluorouracil had promoted beneficial change in vocal fold's cicatrization with less collagen deposition, but there was no significant statistically difference when they were compared between themselves.

Vocal fold lateralization using carbon dioxide laser and fibrin glue

1992 ◽  
Vol 106 (3) ◽  
pp. 226-230 ◽  
Author(s):  
Arne Linder ◽  
Carl-Eric Lindholm
Keyword(s):  
Carbon Dioxide ◽  
Fibrin Glue ◽  
Vocal Fold ◽  
Carbon Dioxide Laser ◽  
Vocal Folds ◽  
Lateral Position ◽  
Endoscopic Method ◽  
Bilateral Vocal Fold Paralysis ◽  
Recent Method

AbstractLateralization of one or both vocal folds is a generally accepted surgical principle for the relief of the airway obstruction caused by bilateral vocal fold paralysis. A modified, entirely endoscopic method of lateralization has been developed, employing a carbon dioxide laser to reduce the bulk of the fold, and fibrin glue to maintain the lateral position. The results of 18 operations on 15 patients, including six who had unsatisfactory results after previous surgery, were analyzed and compared retrospectively with the results from 22 patients operated on before the introduction of the method. The patient's ability to perform everyday activities improved in 12 cases, which paralleled the results of the previous, more cumbersome methods. The incidence of re-operation was comparable, given the shorter follow-up after the more recent method.

scholarly journals Angiogenesis, fibrinogenesis and presence of synechiae after exeresis of a swine vocal fold mucosal microflap and use of topical mitomycin-C

2010 ◽  
Vol 25 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Vinicius Ribas de Carvalho Duarte Fonseca ◽  
Osvaldo Malafaia ◽  
Jurandir Marcondes Ribas Filho ◽  
Paulo Afonso Nunes Nassif ◽  
Nicolau Gregori Czeczko ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Mitomycin C ◽  
Vocal Fold ◽  
Vocal Folds ◽  
Free Edge ◽  
Control Group ◽  
Collagen Deposition ◽  
Group A ◽  
Immunohistochemical Assessment ◽  
Experimental Group

PURPOSE: To evaluate swine vocal fold healing in a period of 30 days after topical mitomycin-C application. METHODS: Twelve swine underwent exeresis of mucosal flaps from the free edge of the anterior third of both vocal folds with a cold instrument (laryngeal scissors). The animals were divided into two groups: EG (Experimental Group), consisting of 6 animals undergoing topical MMC application (4 mg/dL) on the operated area for 4 minutes; CG (Control Group), 6 animals undergoing topical saline solution application on the operated area for 4 minutes. After 30 days, the animals were sacrificed and the larynges were collected and examined for the presence of synechiae as well as a histological immunohistochemical assessment of immature and mature collagen deposition, number of blood vessels and myofibroblasts. RESULTS: Mature collagen deposition in the EG was 452.12 μm² and 1332.31μm² in the CG; immature collagen deposition was 1511.73μm² in the EG and 1020.61μm² in the CG. The number of myofibroblasts was 1.556 in the EG and 3.583 in the CG. The number of blood vessels was 2.565 in EG and 6.917 in the CG. There were no synechiae in the two studied groups. CONCLUSIONS: There was an increase in immature collagen deposition in the experimental group when compared with the control group. There was a decrease in mature collagen deposition in the experimental group when compared with the control group. There was a decrease in the number of myofibroblasts in the experimental group when compared with the control group. A decrease in blood vessels was observed in the experimental group when compared with the control group. There was no synechia formation in either studied group.

Osteoplasty in Disseminated Calvarial Defects Treated with Autologous Adipose-Derived Stem Cells and Autologous Fibrin Glue: Case Report

Skull Base ◽  
2005 ◽  
Vol 15 (S 2) ◽  
Author(s):  
Stefan Lendeckel ◽  
A. Jödicke ◽  
P. Christophis ◽  
K. Heidinger ◽  
H.-P. Howaldt
Keyword(s):  
Stem Cells ◽  
Case Report ◽  
Fibrin Glue ◽  
Adipose Derived Stem Cells ◽  
Autologous Fibrin Glue ◽  
Calvarial Defects

Taming the Cavernous Sinus: Technique of Hemostasis Using Fibrin Glue

Skull Base ◽  
2007 ◽  
Vol 17 (S 2) ◽  
Author(s):  
Ali Krisht ◽  
Niklaus Krayenbuhl ◽  
Ahmad Hafez ◽  
Juha Hernesniemi
Keyword(s):  
Fibrin Glue ◽  
Cavernous Sinus

Microtomography analysis of bone formation in calvarial defects filled with gelatin sponge or fibrin glue

2013 ◽  
Author(s):  
Santana Santos Thiago de ◽  
Helena Bacha Lopes ◽  
Adriana Luiza Almeida ◽  
Marcio Mateus Beloti ◽  
Adalberto Luiz Rosa
Keyword(s):  
Bone Formation ◽  
Fibrin Glue ◽  
Gelatin Sponge ◽  
Calvarial Defects

Prospects for the use of omix-technologies in preclinical practice of production-related diseases of the voice

2020 ◽  
pp. 541-541
Author(s):  
Y. S. Alizade ◽  
L. B. Rudin
Keyword(s):  
At Risk ◽  
Minimally Invasive ◽  
Voice Disorders ◽  
Vocal Folds ◽  
The Voice

The potential predictive possibilities of minimally invasive prenosological diagnosis of voice disorders on the basis of combined Geno - and phenotyping of persons at risk of diseases of the vocal folds of professional origin.

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