Physical activity and cutaneous melanoma risk: A Norwegian population-based cohort study

ObjectiveObesity tends to cluster in families reflecting both common genetics and shared lifestyle patterns within the family environment. The aim of this study was to examine whether parental lifestyle changes over time, exemplified by changes in weight and physical activity, could affect offspring weight in adolescents and if parental education level influenced the relationship.Design, setting and participantsThe population-based cohort study included 4424 parent-offspring participants from the Nord-Trøndelag Health Study, Norway. Exposition was parental change in weight and physical activity over 11 years, and outcome was offspring weight measured in z-scores of body mass index (BMI) in mixed linear models.ResultsMaternal weight reduction by 2–6 kg was significantly associated with lower offspring BMI z-scores: −0.132 (95% CI −0.259 to −0.004) in the model adjusted for education. Parental weight change displayed similar effect patterns on offspring weight regardless of parents’ education level. Further, BMI was consistently lower in families of high education compared with low education in the fully adjusted models. In mothers, reduced physical activity level over time was associated with higher BMI z-scores in offspring: 0.159 (95% CI 0.030 to 0.288). Associations between physical activity change and adolescent BMI was not moderated by parental education levels.ConclusionLifestyle changes in mothers were associated with offspring BMI; reduced weight with lower—and reduced physical activity with higher BMI. Father’s lifestyle changes, however, did not significantly affect adolescent offspring’s weight. Overall, patterns of association between parental changes and offspring’s BMI were independent of parental education levels, though adolescents with parents with high education had lower weight in general.

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Leisure-time physical activity before pregnancy and risk of hyperemesis gravidarum: a population-based cohort study

Preventive Medicine ◽

10.1016/j.ypmed.2019.05.002 ◽

2019 ◽

Vol 125 ◽

pp. 49-54 ◽

Cited By ~ 2

Author(s):

Katrine M. Owe ◽

Nathalie Støer ◽

Borgny H. Wold ◽

Maria C. Magnus ◽

Wenche Nystad ◽

...

Keyword(s):

Physical Activity ◽

Cohort Study ◽

Leisure Time ◽

Leisure Time Physical Activity ◽

Hyperemesis Gravidarum ◽

Population Based

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Disability, body image and sports/physical activity in adult survivors of childhood CNS tumors: population-based outcomes from a cohort study

Journal of Neuro-Oncology ◽

10.1007/s11060-012-1039-5 ◽

2013 ◽

Vol 112 (1) ◽

pp. 99-106 ◽

Cited By ~ 12

Author(s):

Krister K. Boman ◽

Lina Hörnquist ◽

Lisanne De Graaff ◽

Jenny Rickardsson ◽

Birgitta Lannering ◽

...

Keyword(s):

Physical Activity ◽

Body Image ◽

Cohort Study ◽

Adult Survivors ◽

Population Based ◽

Cns Tumors

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Menopausal hormone therapy and colorectal cancer: a linkage between nationwide registries in Norway

BMJ Open ◽

10.1136/bmjopen-2017-017639 ◽

2017 ◽

Vol 7 (11) ◽

pp. e017639 ◽

Cited By ~ 9

Author(s):

Edoardo Botteri ◽

Nathalie C Støer ◽

Solveig Sakshaug ◽

Sidsel Graff-Iversen ◽

Siri Vangen ◽

...

Keyword(s):

Colorectal Cancer ◽

Cohort Study ◽

Hormone Therapy ◽

Population Based ◽

Menopausal Hormone Therapy ◽

Anatomic Site ◽

Oral Formulations ◽

Norwegian Population ◽

Progestin Therapy ◽

Rate Ratios

ObjectivesWith the present study, we aimed to investigate the association between menopausal hormone therapy (HT) and risk of colorectal cancer (CRC).SettingCohort study based on the linkage of Norwegian population-based registries.ParticipantsWe selected 466822 Norwegian women, aged 55–79, alive and residing in Norway as of 1 January 2004, and we followed them from 2004 to 2008. Each woman contributed person-years at risk as non-user, current user and/or past HT user.Outcome measuresThe outcome of interest was adenocarcinoma of the colorectal tract, overall, by anatomic site and stage at diagnosis. Incidence rate ratios (RRs) with 95% CIs were estimated by Poisson regression and were used to evaluate the association between HT and CRC incidence.ResultsDuring the median follow-up of 4.8 years, 138 655 (30%) women received HT and 3799 (0.8%) incident CRCs occurred. Current, but not past, use of HT was associated with a lower risk of CRC (RR 0.88; 95% CI 0.80 to 0.98). RRs for localised, regionally advanced and metastatic CRC were 1.13 (95% CI 0.91 to 1.41), 0.81 (95% CI 0.70 to 0.94) and 0.79 (95% CI 0.62 to 1.00), respectively. RRs for current use of oestrogen therapy (ET) were 0.91 (95% CI 0.80 to 1.04) while RR for current use of combined oestrogen–progestin therapy (EPT) was 0.85 (95% CI 0.70 to 1.03), as compared with no use of HT. The same figures for ET and EPT in oral formulations were 0.83 (95% CI 0.68 to 1.03) and 0.86 (95% CI 0.71 to 1.05), respectively.ConclusionsIn our nationwide cohort study, HT use lowered the risk of CRC, specifically the most advanced CRC.

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