Comparison of the effect of valsartan and lisinopril on autonomic nervous system activity in chronic heart failure

2003 ◽  
Vol 146 (5) ◽  
pp. 854 ◽  
Author(s):  
Elisabetta De Tommasi ◽  
Massimo Iacoviello ◽  
Roberta Romito ◽  
Claudio Ceconi ◽  
Pietro Guida ◽  
...  
2002 ◽  
Vol 282 (6) ◽  
pp. H2076-H2083 ◽  
Author(s):  
Vladimir Shusterman ◽  
Irmute Usiene ◽  
Chivonne Harrigal ◽  
Joon Sup Lee ◽  
Toru Kubota ◽  
...  

Transgenic mice are widely used to study cardiac function, but strain-dependent differences in autonomic nervous system activity (ANSA) have not been explored. We compared 1) short-term pharmacological responses of cardiac rhythm in FVB vs. C57Black6/SV129 wild-type mice and 2) long-term physiological dynamics of cardiac rhythm and survival in tumor necrosis factor (TNF)-α transgenic mice with heart failure (TNF-α mice) on defined backgrounds. Ambulatory telemetry electrocardiographic recordings and response to saline, adrenergic, and cholinergic agents were examined in FVB and C57Black6/SV129 mice. In FVB mice, baseline heart rate (HR) was higher and did not change after injection of isoproterenol or atropine but decreased with propranolol. In C57Black6/SV129 mice, HR did not change with propranolol but increased with isoproterenol or atropine. Mean HR, but not indexes of HR variability, was an excellent predictor of response to autonomic agents. The proportion of surviving animals was higher in TNF-α mice on an FVB background than on a mixed FVB/C57Black6 background. The homeostatic states of ANSA are strain specific, which can explain the interstrain differences in mean HR, pharmacological responses, and survival of animals with congestive heart failure. Strain-specific differences should be considered in selecting the strains of mice used for transgenic and gene targeting experiments.


Nutrients ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 565 ◽  
Author(s):  
Morton Burt ◽  
Brenda Mangelsdorf ◽  
Stephen Stranks ◽  
Arduino Mangoni

2018 ◽  
Vol 9 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Elias Tsiompanidis ◽  
Spyros I Siakavellas ◽  
Anastasios Tentolouris ◽  
Ioanna Eleftheriadou ◽  
Stamatia Chorepsima ◽  
...  

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