In Situ Detection of Human Herpesvirus 6 in Retinitis Associated with Acquired Immunodeficiency Syndrome

1992 ◽  
Vol 114 (3) ◽  
pp. 375-377 ◽  
Author(s):  
Isabelle Reux ◽  
Anne-Marie Fillet ◽  
Henri Agut ◽  
Christine Katlama ◽  
Jean-Jacques Hauw ◽  
...  
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Acquired Immunodeficiency ◽  
Herpesvirus 6 ◽  
Immunodeficiency Syndrome ◽  
In Situ Detection

Human herpesvirus 6

1997 ◽  
Vol 1 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Stephen Dewhurst ◽  
David Skrincosky ◽  
Nanette van Loon
Keyword(s):  
Neurological Disorders ◽  
Human Herpesvirus ◽  
Chronic Fatigue ◽  
Human Herpesvirus 6 ◽  
Common Cause ◽  
Exanthem Subitum ◽  
Acquired Immunodeficiency ◽  
Herpesvirus 6 ◽  
Almost All ◽  
Immunodeficiency Syndrome

Human herpesvirus 6 (HHV-6) is a T-lymphotropic herpesvirus, which infects almost all children by the age of two years and persists lifelong. Two distinct variants of HHV-6, HHV-6A and HHV-6B, have been described, and the latter has been shown to be a common cause of acute febrile illnesses in young children, including exanthem subitum (roseola). HHV-6 has also been associated with a number of neurological disorders, including encephalitis and seizures, and the virus has been postulated to play a role in acquired immunodeficiency syndrome (AIDS), multiple sclerosis (MS) and chronic fatigue immunodeficiency syndrome (CFIDS). This review provides a critical summary of research conducted on HHV-6.

Inheritance of Chromosomally Integrated Human Herpesvirus 6 DNA

Blood ◽  
1999 ◽  
Vol 94 (5) ◽  
pp. 1545-1549 ◽  
Author(s):  
Masanori Daibata ◽  
Takahiro Taguchi ◽  
Yuiko Nemoto ◽  
Hirokuni Taguchi ◽  
Isao Miyoshi
Keyword(s):  
Dna Sequences ◽  
Viral Genome ◽  
Family Members ◽  
Human Herpesvirus ◽  
Single Step ◽  
Human Herpesvirus 6 ◽  
Viral Genomes ◽  
Herpesvirus 6

Abstract Human herpesvirus 6 (HHV-6) genome has been detected in several human lymphoproliferative disorders with no signs of active viral infection, and found to be integrated into chromosomes in some cases. We previously reported a woman with HHV-6–infected Burkitt’s lymphoma. Fluorescence in situ hybridization showed that the viral genome was integrated into the long arm of chromosome 22 (22q13). The patient’s asymptomatic husband also carried HHV-6 DNA integrated at chromosome locus 1q44. To assess the possibility of chromosomal transmission of HHV-6 DNA, we looked for HHV-6 DNA in the peripheral blood of their daughter. She had HHV-6 DNA on both chromosomes 22q13 and 1q44, identical to the site of viral integration of her mother and father, respectively. The findings suggested that her viral genomes were inherited chromosomally from both parents. The 3 family members were all seropositive for HHV-6, but showed no serological signs of active infection. To confirm the presence of HHV-6 DNA sequences, we performed polymerase chain reaction (PCR) with 7 distinct primer pairs that target different regions of HHV-6. The viral sequences were consistently detected by single-step PCR in all 3 family members. We propose a novel latent form for HHV-6, in which integrated viral genome can be chromosomally transmitted. The possible role of the chromosomally integrated HHV-6 in the pathogenesis of lymphoproliferative diseases remains to be explained.

scholarly journals Erythrovirus B19 infection in acquired immunodeficiency syndrome: screening by histopathology, immunohistochemistry, and in situ hybridization

2006 ◽  
Vol 101 (4) ◽  
pp. 407-414 ◽  
Author(s):  
Sérgio Setúbal ◽  
Solange Artimos de Oliveira ◽  
Andréia Rodrigues Cordovil Pires ◽  
Eliene Carvalho da Fonseca ◽  
Luiz Antônio Bastos Camacho ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acquired Immunodeficiency Syndrome ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Detection of human herpesvirus-6 transcripts in carbamazepine-induced hypersensitivity syndrome by in situ hybridization

2009 ◽  
Vol 54 (2) ◽  
pp. 134-136 ◽  
Author(s):  
Takahiro Watanabe ◽  
Hiroko Nakashima ◽  
Hanako Ohmatsu ◽  
Naoki Sakurai ◽  
Tomonori Takekoshi ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Human Herpesvirus ◽  
Hypersensitivity Syndrome ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

Inheritance of Chromosomally Integrated Human Herpesvirus 6 DNA

Blood ◽  
1999 ◽  
Vol 94 (5) ◽  
pp. 1545-1549 ◽  
Author(s):  
Masanori Daibata ◽  
Takahiro Taguchi ◽  
Yuiko Nemoto ◽  
Hirokuni Taguchi ◽  
Isao Miyoshi
Keyword(s):  
Dna Sequences ◽  
Viral Genome ◽  
Family Members ◽  
Human Herpesvirus ◽  
Single Step ◽  
Human Herpesvirus 6 ◽  
Viral Genomes ◽  
Herpesvirus 6

Human herpesvirus 6 (HHV-6) genome has been detected in several human lymphoproliferative disorders with no signs of active viral infection, and found to be integrated into chromosomes in some cases. We previously reported a woman with HHV-6–infected Burkitt’s lymphoma. Fluorescence in situ hybridization showed that the viral genome was integrated into the long arm of chromosome 22 (22q13). The patient’s asymptomatic husband also carried HHV-6 DNA integrated at chromosome locus 1q44. To assess the possibility of chromosomal transmission of HHV-6 DNA, we looked for HHV-6 DNA in the peripheral blood of their daughter. She had HHV-6 DNA on both chromosomes 22q13 and 1q44, identical to the site of viral integration of her mother and father, respectively. The findings suggested that her viral genomes were inherited chromosomally from both parents. The 3 family members were all seropositive for HHV-6, but showed no serological signs of active infection. To confirm the presence of HHV-6 DNA sequences, we performed polymerase chain reaction (PCR) with 7 distinct primer pairs that target different regions of HHV-6. The viral sequences were consistently detected by single-step PCR in all 3 family members. We propose a novel latent form for HHV-6, in which integrated viral genome can be chromosomally transmitted. The possible role of the chromosomally integrated HHV-6 in the pathogenesis of lymphoproliferative diseases remains to be explained.

Sign in / Sign up

Export Citation Format

Share Document