scholarly journals Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions

2000 ◽  
Vol 157 (1) ◽  
pp. 287-295 ◽  
Author(s):  
Imad About ◽  
Dominique Laurent-Maquin ◽  
Urban Lendahl ◽  
Thimios A. Mitsiadis
Keyword(s):  
Nestin Expression ◽  
Human Teeth ◽  
Adult Human ◽  
Pathological Conditions

scholarly journals Identification of a protein-containing enamel matrix layer which bridges with the dentine–enamel junction of adult human teeth

2012 ◽  
Vol 57 (12) ◽  
pp. 1585-1594 ◽  
Author(s):  
Vladimir Dusevich ◽  
Changqi Xu ◽  
Yong Wang ◽  
Mary P. Walker ◽  
Jeff P. Gorski
Keyword(s):  
Enamel Matrix ◽  
Human Teeth ◽  
Adult Human ◽  
Matrix Layer

scholarly journals Cardiac Fibroblast-Derived Extracellular Matrix (Biomatrix) as a Model for the Studies of Cardiac Primitive Cell Biological Properties in Normal and Pathological Adult Human Heart

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Clotilde Castaldo ◽  
Franca Di Meglio ◽  
Rita Miraglia ◽  
Anna Maria Sacco ◽  
Veronica Romano ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Tissue Regeneration ◽  
Human Heart ◽  
Cardiac Tissue ◽  
Biological Properties ◽  
Cardiac Fibroblast ◽  
Primitive Cell ◽  
Matricellular Proteins ◽  
Adult Human ◽  
Pathological Conditions

Cardiac tissue regeneration is guided by stem cells and their microenvironment. It has been recently described that both cardiac stem/primitive cells and extracellular matrix (ECM) change in pathological conditions. This study describes the method for the production of ECM typical of adult human heart in the normal and pathological conditions (ischemic heart disease) and highlights the potential use of cardiac fibroblast-derived ECM forin vitrostudies of the interactions between ECM components and cardiac primitive cells responsible for tissue regeneration. Fibroblasts isolated from adult human normal and pathological heart with ischemic cardiomyopathy were cultured to obtain extracellular matrix (biomatrix), composed of typical extracellular matrix proteins, such as collagen and fibronectin, and matricellular proteins, laminin, and tenascin. After decellularization, this substrate was used to assess biological properties of cardiac primitive cells: proliferation and migration were stimulated by biomatrix from normal heart, while both types of biomatrix protected cardiac primitive cells from apoptosis. Our model can be used for studies of cell-matrix interactions and help to determine the biochemical cues that regulate cardiac primitive cell biological properties and guide cardiac tissue regeneration.

Notch2 protein distribution in human teeth under normal and pathological conditions

2003 ◽  
Vol 282 (2) ◽  
pp. 101-109 ◽  
Author(s):  
Thimios A. Mitsiadis ◽  
Annick Roméas ◽  
Urban Lendahl ◽  
Paul T. Sharpe ◽  
Jean Christophe Farges
Keyword(s):  
Protein Distribution ◽  
Human Teeth ◽  
Pathological Conditions

Dentino-Enamel Cuticle Present in Adult Human Teeth

1949 ◽  
Vol 28 (6) ◽  
pp. 565-568 ◽  
Author(s):  
Victorino G. Villa
Keyword(s):  
Human Teeth ◽  
Adult Human

αvβ3 Integrin Expression in Human Odontoblasts and Co-localization with Osteoadherin

2004 ◽  
Vol 83 (7) ◽  
pp. 552-556 ◽  
Author(s):  
M. Lucchini ◽  
M.-L. Couble ◽  
A. Romeas ◽  
M.-J. Staquet ◽  
F. Bleicher ◽  
...  
Keyword(s):  
Staining Intensity ◽  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Human Teeth ◽  
Transmembrane Receptors ◽  
Cusp Region ◽  
Putative Receptor ◽  
Tissue Organization ◽  
Pathological Conditions

Integrins are heterodimeric transmembrane receptors which promote cell adhesion, thus contributing to the maintenance of tissue organization in both normal and pathological conditions. To characterize the way odontoblasts may interact with other cells and the extracellular matrix in human teeth, we studied expression of αvβ3 integrin, a putative receptor for osteoadherin. We showed that αvβ3 integrin expression was restricted to odontoblasts, blood vessels, and small rounded cells in sound and carious pulp. Odontoblast staining intensity increased from the apical to the cusp region. Osteoadherin staining was strong in the whole odontoblast layer (with a slight decrease in the cusp region) and in predentin. Odontoblasts differentiating in vitro were stained with the anti-αvβ3 integrin antibody, first at the level of intercellular contacts, then throughout the cell membrane. These results suggest that the αvβ3 integrin could play a role in interodontoblast adhesion and odontoblast binding to the surrounding predentin/dentin/pulp matrix, possibly through osteoadherin.

scholarly journals E- and N-Cadherin Distribution in Developing and Functional Human Teeth under Normal and Pathological Conditions

2002 ◽  
Vol 160 (6) ◽  
pp. 2123-2133 ◽  
Author(s):  
Robert Heymann ◽  
Imad About ◽  
Urban Lendahl ◽  
Jean-Claude Franquin ◽  
Björn Öbrink ◽  
...  
Keyword(s):  
Human Teeth ◽  
Pathological Conditions
Sign in / Sign up

Export Citation Format

Share Document