The Fine Surface View of the Adult Human Eustachian Tube in Normal and Pathological Conditions

2015 ◽  
pp. 72-84
Author(s):  
F. Hiraide
Keyword(s):  
Eustachian Tube ◽  
Surface View ◽  
Adult Human ◽  
Pathological Conditions ◽  
Fine Surface

The fine surface view of the human adult eustachian tube

1983 ◽  
Vol 97 (2) ◽  
pp. 149-157 ◽  
Author(s):  
Fumihisa Hiraide ◽  
Tetsuzo Inouye
Keyword(s):  
Eustachian Tube ◽  
Surface View ◽  
Human Adult ◽  
Fine Surface

scholarly journals Cardiac Fibroblast-Derived Extracellular Matrix (Biomatrix) as a Model for the Studies of Cardiac Primitive Cell Biological Properties in Normal and Pathological Adult Human Heart

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Clotilde Castaldo ◽  
Franca Di Meglio ◽  
Rita Miraglia ◽  
Anna Maria Sacco ◽  
Veronica Romano ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Tissue Regeneration ◽  
Human Heart ◽  
Cardiac Tissue ◽  
Biological Properties ◽  
Cardiac Fibroblast ◽  
Primitive Cell ◽  
Matricellular Proteins ◽  
Adult Human ◽  
Pathological Conditions

Cardiac tissue regeneration is guided by stem cells and their microenvironment. It has been recently described that both cardiac stem/primitive cells and extracellular matrix (ECM) change in pathological conditions. This study describes the method for the production of ECM typical of adult human heart in the normal and pathological conditions (ischemic heart disease) and highlights the potential use of cardiac fibroblast-derived ECM forin vitrostudies of the interactions between ECM components and cardiac primitive cells responsible for tissue regeneration. Fibroblasts isolated from adult human normal and pathological heart with ischemic cardiomyopathy were cultured to obtain extracellular matrix (biomatrix), composed of typical extracellular matrix proteins, such as collagen and fibronectin, and matricellular proteins, laminin, and tenascin. After decellularization, this substrate was used to assess biological properties of cardiac primitive cells: proliferation and migration were stimulated by biomatrix from normal heart, while both types of biomatrix protected cardiac primitive cells from apoptosis. Our model can be used for studies of cell-matrix interactions and help to determine the biochemical cues that regulate cardiac primitive cell biological properties and guide cardiac tissue regeneration.

Characterization of mucins in human middle ear and Eustachian tube

2001 ◽  
Vol 280 (6) ◽  
pp. L1157-L1167 ◽  
Author(s):  
Jizhen Lin ◽  
Vladimir Tsuprun ◽  
Hirokazu Kawano ◽  
Michael M. Paparella ◽  
Zhiqiang Zhang ◽  
...  
Keyword(s):  
Otitis Media ◽  
Eustachian Tube ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Middle Ear Mucosa ◽  
Pathological Conditions ◽  
Mucin Expression ◽  
Mucin Genes ◽  
Human Middle Ear

Mucins are important glycoproteins in the mucociliary transport system of the middle ear and Eustachian tube. Little is known about mucin expression within this system under physiological and pathological conditions. This study demonstrated the expression of MUC5B, MUC5AC, MUC4, and MUC1 in the human Eustachian tube, whereas only MUC5B mucin expression was demonstrated in noninflamed middle ears. MUC5B and MUC4 mucin genes were upregulated 4.2- and 6-fold, respectively, in middle ears with chronic otitis media (COM) or mucoid otitis media (MOM). This upregulation of mucin genes was accompanied by an increase of MUC5B- and MUC4-producing cells in the middle ear mucosa. Electron microscopy of the secretions from COM and MOM showed the presence of chainlike polymeric mucin. These data indicate that the epithelium of the middle ear and Eustachian tube expresses distinct mucin profiles and that MUC5B and MUC4 mucins are highly produced and secreted in the diseased middle ear. These mucins may form thick mucous effusion in the middle ear cavity and compromise the function of the middle ear.

scholarly journals Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions

2000 ◽  
Vol 157 (1) ◽  
pp. 287-295 ◽  
Author(s):  
Imad About ◽  
Dominique Laurent-Maquin ◽  
Urban Lendahl ◽  
Thimios A. Mitsiadis
Keyword(s):  
Nestin Expression ◽  
Human Teeth ◽  
Adult Human ◽  
Pathological Conditions

The Fine Surface View of the Pharyngeal Tonsil

ORL ◽  
1974 ◽  
Vol 36 (5) ◽  
pp. 275-284 ◽  
Author(s):  
Fumihisa Hiraide ◽  
Yasuya Nomura
Keyword(s):  
Surface View ◽  
Fine Surface ◽  
Pharyngeal Tonsil

Morphological and elemental analysis of isolated incubated frog retina-choroid

1984 ◽  
Vol 42 ◽  
pp. 298-299
Author(s):  
B. J. Panessa-Warren ◽  
J. B. Warren ◽  
H. W. Kraner
Keyword(s):  
Elemental Analysis ◽  
Pigment Epithelium ◽  
Human Retina ◽  
Healthy Individuals ◽  
Anterior Portion ◽  
Pathological Conditions ◽  
Frog Retina ◽  
Isolated Retina ◽  
Vertebrate Eye ◽  
Retina Pigment Epithelium

Our previous studies have demonstrated that abnormally high amounts of calcium (Ca) and zinc (Zn) can be accumulated in human retina-choroid under pathological conditions and that barium (Ba), which was not detected in the eyes of healthy individuals, is deposited in the retina pigment epithelium (RPE), and to a lesser extent in the sensory retina and iris. In an attempt to understand how these cations can be accumulated in the vertebrate eye, a morphological and microanalytical study of the uptake and loss of specific cations (K, Ca,Ba,Zn) was undertaken with incubated Rana catesbiana isolated retina and RPE preparations. Large frogs (650-800 gms) were dark adapted, guillotined and their eyes enucleated in deep ruby light. The eyes were hemisected behind the ora serrata and the anterior portion of the eye removed. The eyecup was bisected along the plane of the optic disc and the two segments of retina peeled away from the RPE and incubated.

An Ultrastructural Study of the Proliferation Patterns of the Reserve Cells of the Human Cervix Uteri

1972 ◽  
Vol 30 ◽  
pp. 80-81
Author(s):  
Takanori Sohda ◽  
Hiroshi Saito ◽  
Goro Asano ◽  
Katsunari Fukushi ◽  
Katsuya Suzuki ◽  
...  
Keyword(s):  
Ultrastructural Study ◽  
Age Groups ◽  
Point Of View ◽  
University Hospital ◽  
Cervix Uteri ◽  
Morphological Aspect ◽  
Functional Aspect ◽  
Pathological Conditions ◽  
Human Cervix ◽  
Morphological Patterns

Recently, the functional aspect as well as morphological aspect of the reserve cells in the cervix uteri drew much attention in view of the carcinogenesis in squamocolumunar junction. In this communication, the authors elucidate the ultrastructural features of the reserve cells in patients of various age groups visiting our university hospital and affiliated hospital.From conventional light microscopic point of view, the reserve cells tend to be pronounced in various pathological conditions, such as the persisting inflammation, proliferative disorders and irritation of hormones. The morphological patterns of the reserve cells from various stage and degree of irritation were observed.

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