Regulation by androgen of mRNA level for the major urinary protein complex in mouse liver

1977 ◽  
Vol 77 (2) ◽  
pp. 628-633 ◽  
Author(s):  
Shoji Osawa ◽  
Shiro Tomino
Keyword(s):  
Protein Complex ◽  
Mouse Liver ◽  
Mrna Level ◽  
Urinary Protein ◽  
Major Urinary Protein

Major Urinary Protein Complex of Normal Mice: Origin

Science ◽  
1965 ◽  
Vol 149 (3687) ◽  
pp. 981-982 ◽  
Author(s):  
J. S. Finlayson ◽  
R. Asofsky ◽  
M. Potter ◽  
C. C. Runner
Keyword(s):  
Protein Complex ◽  
Urinary Protein ◽  
Major Urinary Protein

Differential, multihormonal regulation of the mouse major urinary protein gene family in the liver

1983 ◽  
Vol 3 (12) ◽  
pp. 2232-2240
Author(s):  
J L Knopf ◽  
J F Gallagher ◽  
W A Held
Keyword(s):  
Growth Hormone ◽  
Mouse Liver ◽  
Protein Gene ◽  
Peptide Hormone ◽  
Urinary Protein ◽  
Receptor Protein ◽  
Normal Male ◽  
Mrna Levels ◽  
Major Urinary Protein ◽  
Testosterone Administration

The hormonal requirements for the regulation of the major urinary protein (MUP) mRNA levels in mouse liver have been examined. Previous experiments have shown that administration of testosterone to female or castrated male mice increases MUP mRNA levels approximately fivefold to normal male levels. We have found that thyroxine and the peptide hormone, growth hormone, each had a pronounced effect on MUP mRNA levels. MUP mRNA was reduced 150-fold in growth-hormone-deficient mutant mice (little). The administration of growth hormone and thyroxine induced MUP mRNA approximately 150-fold, and when administered together, they induced MUP mRNA approximately 1,000-fold. testosterone administration. When administered separately to these mice, growth hormone and thyroxine induced with MUP mRNA approximately 150-fold, and when administered together, they induced MUP mRNA approximately 1,000-fold. Testicular feminized mice, which lack a functional major testosterone receptor protein, can also be induced to male levels by treatment with both growth hormone and thyroxine. In addition, we present evidence which indicates that growth hormone, thyroxine, and testosterone differentially regulate the levels of distinct MUP mRNA species.

scholarly journals Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver

2017 ◽  
Vol 292 (16) ◽  
pp. 6765-6774 ◽  
Author(s):  
Jieyun Jiang ◽  
Kate Townsend Creasy ◽  
Justin Purnell ◽  
Martha L. Peterson ◽  
Brett T. Spear
Keyword(s):  
Gene Expression ◽  
Mouse Liver ◽  
Protein Gene ◽  
Zinc Fingers ◽  
Urinary Protein ◽  
Major Urinary Protein

Components of the major urinary protein complex of inbred mice: Separation and peptide mapping

1968 ◽  
Vol 2 (2) ◽  
pp. 127-140 ◽  
Author(s):  
J. S. Finlayson ◽  
J. F. Mushinski ◽  
D. M. Hudson ◽  
M. Potter
Keyword(s):  
Protein Complex ◽  
Peptide Mapping ◽  
Inbred Mice ◽  
Urinary Protein ◽  
Major Urinary Protein

scholarly journals Differential, multihormonal regulation of the mouse major urinary protein gene family in the liver.

1983 ◽  
Vol 3 (12) ◽  
pp. 2232-2240 ◽  
Author(s):  
J L Knopf ◽  
J F Gallagher ◽  
W A Held
Keyword(s):  
Growth Hormone ◽  
Mouse Liver ◽  
Protein Gene ◽  
Peptide Hormone ◽  
Urinary Protein ◽  
Receptor Protein ◽  
Normal Male ◽  
Mrna Levels ◽  
Major Urinary Protein ◽  
Testosterone Administration

The hormonal requirements for the regulation of the major urinary protein (MUP) mRNA levels in mouse liver have been examined. Previous experiments have shown that administration of testosterone to female or castrated male mice increases MUP mRNA levels approximately fivefold to normal male levels. We have found that thyroxine and the peptide hormone, growth hormone, each had a pronounced effect on MUP mRNA levels. MUP mRNA was reduced 150-fold in growth-hormone-deficient mutant mice (little). The administration of growth hormone and thyroxine induced MUP mRNA approximately 150-fold, and when administered together, they induced MUP mRNA approximately 1,000-fold. testosterone administration. When administered separately to these mice, growth hormone and thyroxine induced with MUP mRNA approximately 150-fold, and when administered together, they induced MUP mRNA approximately 1,000-fold. Testicular feminized mice, which lack a functional major testosterone receptor protein, can also be induced to male levels by treatment with both growth hormone and thyroxine. In addition, we present evidence which indicates that growth hormone, thyroxine, and testosterone differentially regulate the levels of distinct MUP mRNA species.

scholarly journals Linkage of one component of the major urinary protein complex of mice to the brown coat color locus

1967 ◽  
Vol 10 (2) ◽  
pp. 195-198 ◽  
Author(s):  
D. M. Hudson ◽  
J. S. Finlayson ◽  
M. Potter
Keyword(s):  
Linkage Group ◽  
Mus Musculus ◽  
Protein Complex ◽  
Coat Color ◽  
Urinary Protein ◽  
Group Viii ◽  
Electrophoretic Variation ◽  
Major Urinary Protein

Two codominant alleles, Mup-a1 and Mup-a2, controlling electrophoretic variation of one of the components of the major urinary protein (MUP) complex of the mouse Mus musculus have been found to be linked to the black–brown coat color alleles (linkage group VIII).

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