Glutathione depletion and the production of reactive oxygen species in isolated hepatocyte suspensions

2000 ◽  
Vol 127 (3) ◽  
pp. 201-217 ◽  
Author(s):  
M.A. Tirmenstein ◽  
F.A. Nicholls-Grzemski ◽  
J.-G. Zhang ◽  
M.W. Fariss
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Glutathione Depletion ◽  
Oxygen Species

A small molecule that induces reactive oxygen species via cellular glutathione depletion

2014 ◽  
Vol 463 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Tatsuro Kawamura ◽  
Yasumitsu Kondoh ◽  
Makoto Muroi ◽  
Makoto Kawatani ◽  
Hiroyuki Osada
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Lines ◽  
Cancer Cell ◽  
Small Molecule ◽  
Reactive Oxygen ◽  
Cancer Cell Lines ◽  
Glutathione Depletion ◽  
Oxygen Species ◽  
Chemical Library ◽  
Cytotoxic Compound

A new cytotoxic compound was found in our chemical library. We revealed that the compound induced reactive oxygen species through glutathione depletion. Moreover, the compound was effective against several cancer cell lines including those harbouring KRAS.

Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion

2018 ◽  
Vol 26 (8) ◽  
pp. 1453-1461 ◽  
Author(s):  
Julian Wilke ◽  
Tatsuro Kawamura ◽  
Nobumoto Watanabe ◽  
Hiroyuki Osada ◽  
Slava Ziegler ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Glutathione Depletion ◽  
Oxygen Species
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