Inhibition of cytochrome P450 2B6 activity by hormone replacement therapy and oral contraceptive as measured by bupropion hydroxylation

2003 ◽  
Vol 74 (4) ◽  
pp. 326-333 ◽  
Author(s):  
S Palovaara
Keyword(s):  
Cytochrome P450 ◽  
Hormone Replacement Therapy ◽  
Oral Contraceptive ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Cytochrome P450 2B6

Sudden sensorineural deafness and hormone replacement therapy

1996 ◽  
Vol 110 (12) ◽  
pp. 1148-1150 ◽  
Author(s):  
David Strachan
Keyword(s):  
Hearing Loss ◽  
Hormone Replacement Therapy ◽  
Oral Contraceptive ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Oral Contraceptive Pill ◽  
Sensorineural Deafness ◽  
Electrolyte Balance ◽  
Auditory Pathways ◽  
Neurotransmitter Receptor

AbstractWhilst the oral contraceptive pill (OC) has been implicated on a number oif occasions as a cause of sensorineural hearing loss, there are no published reports linking hormone replacement therapy (HRT) to otological symptoms. A case of sensorineural loss with tinnitus following commencement of HRT is described, followed by a discussion outlining the fundamental differences between the OC and HRT, thus expaining why a vascular aetiology is unlikely. It is hypothesized that otological symptoms in such cases may be due to the effect of oestrogens on electrolyte balance disturbing inner ear function and also a direct effect on the auditory pathways mediated in part by alterations in neurotransmitter receptor concentrations.

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