KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats

The objective of this research was to evaluate the effect of feed supplemented with baker’s yeast on survival rate of nile tilapia larvae and to determine the effective dose of baker’s yeast that could optimally improve larval quality. The research was conducted at Pathology and Clinic of Fish Disease from June – September 2014. Fish as brood stock candidates was cultivated at five concrete tanks (2x1x1 m3) at a density of 30 fish per tank. Each tank was equipped with water inlet, outlet and water pump for recirculating and aerating. After seven days of adaptation, fish was fed pellet supplemented with baker’s yeast at five different doses (0, 10, 20, 30, 40 g/kg food) for four consecutive weeks at 4%/bb/day, twice daily. Larva was captured with seser and moved into five glass aquaria with density of 20 larvae/aquarium and reared for two weeks. Data collected was survival rate of larvae achieved until the end of larval rearing. Research result showed that larvae produced by brood stock fed food supplemented with 10 g baker’s yeast per kg food had the highest survival rate namely 60%. As conclusion, supplementation of baker’s yeast into brood stock feed might increase survival rate of larvae. Keywords: nile tilapia, baker’s yeast, larvae, survival rate

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Pretreatment with Sarafotoxin 6c Prior to Coronary Occlusion Protects Against Infarction and Arrhythmias via Cardiomyocyte Mitochondrial KATP Channel Activation in the Intact Rabbit Heart During Ischemia/Reperfusion

Cardiovascular Drugs and Therapy ◽

10.1007/s10557-007-6031-5 ◽

2007 ◽

Vol 21 (4) ◽

pp. 243-251 ◽

Cited By ~ 8

Author(s):

Biswadeep Das ◽

Chayna Sarkar ◽

P Ravi Shankar

Keyword(s):

Katp Channel ◽

Coronary Occlusion ◽

Ischemia Reperfusion ◽

Rabbit Heart ◽

Channel Activation ◽

Mitochondrial Katp Channel ◽

Intact Rabbit

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Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis

Brain Research ◽

10.1016/j.brainres.2015.06.034 ◽

2015 ◽

Vol 1622 ◽

pp. 368-376 ◽

Cited By ~ 14

Author(s):

Nereida Valero ◽

Jesús Mosquera ◽

Sirley Alcocer ◽

Ernesto Bonilla ◽

Jenny Salazar ◽

...

Keyword(s):

Oxidative Stress ◽

Ascorbic Acid ◽

Survival Rate ◽

Venezuelan Equine Encephalitis ◽

Increase Survival Rate ◽

Viral Titers

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Impaired microvascular response to graded coronary occlusion in diabetic and hyperglycemic dogs

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1995.268.4.h1667 ◽

1995 ◽

Vol 268 (4) ◽

pp. H1667-H1674 ◽

Cited By ~ 13

Author(s):

J. R. Kersten ◽

L. A. Brooks ◽

K. C. Dellsperger

Keyword(s):

Katp Channel ◽

Coronary Occlusion ◽

Perfusion Pressure ◽

Coronary Artery Occlusion ◽

Coronary Perfusion Pressure ◽

Artery Occlusion ◽

Coronary Perfusion ◽

Severe Stenosis ◽

Glucose Levels ◽

Mild Stenosis

The hypothesis that coronary microvascular responses to ischemia are impaired in diabetes was tested in 9 alloxan-treated (60 mg/kg i.v.), 8 hyperglycemic, and 16 control dogs. Arteriolar diameters were measured in intact beating left ventricle by use of stroboscopic epi-illumination and intravital microscopy with fluorescence microangiography. Coronary arterial diameters were measured during graded reductions in mean coronary perfusion pressure to 60 +/- 1 (SE) mmHg (mild stenosis), 39 +/- 1 mmHg (severe stenosis), and 26 +/- 1 mmHg (coronary artery occlusion). Blood glucose levels were 95 +/- 5, 264 +/- 17, and 277 +/- 15 mg/dl in control, diabetic, and hyperglycemic animals, respectively. In control dogs, arteriolar microvessels (< 100 microns) dilated (24 +/- 5, 31 +/- 5, and 26 +/- 6% change in diameter from baseline during mild stenosis, severe stenosis, and coronary occlusion, respectively). Diabetes or hyperglycemia prevented the normal dilatory response and resulted in decreases in microvascular diameter during decreases in perfusion pressure (-2 +/- 3, -4 +/- 3, and -15 +/- 4% change in diameter in diabetic animals and -11 +/- 2, -9 +/- 4, and -8 +/- 5% change in diameter in hyperglycemic animals). Large-vessel (> 100 microns) dilation was also significantly impaired in diabetic and hyperglycemic animals. Myocardial perfusion was significantly lower in the epicardium during a severe stenosis in diabetic and hyperglycemic than in control dogs. Because the ATP-sensitive K+ (KATP) channel mediates this response in normal animals, we tested the hypothesis that KATP channel responsiveness is impaired in diabetes and hyperglycemia.(ABSTRACT TRUNCATED AT 250 WORDS)

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Laryngotracheal Autograft for Postcricoid Carcinoma; A Reevaluation

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348947408300410 ◽

1974 ◽

Vol 83 (4) ◽

pp. 481-486 ◽

Cited By ~ 7

Author(s):

Max L. Som

Keyword(s):

At Risk ◽

Survival Rate ◽

Neck Dissection ◽

Lymphatic Metastasis ◽

Second Primary ◽

Tracheoesophageal Groove ◽

Not At Risk ◽

Skip Areas ◽

Increase Survival Rate

Of 84 surgically treated cases of postcricoid carcinoma, 23 had a pharynxesophageal reconstruction by use of a laryngotracheal autograft. This procedure is most suitable in females with manifestations of the Paterson-Broun-Kelly syndrome. The distal esophagus is not “at risk” because of skip areas or second primary lesions. Failures are due predominantly to inability to control the lymphatic metastasis. Stomal recurrence may be due to ascending metastasis from the tracheoesophageal groove and mediastinum. A routine combined neck dissection is urged in all instances. Mediastinal node extirpation with or without resection of the manubrium may increase survival rate. Adequate surgical exposure with visualization, palpation, and exploration of the extent of the cancer is suggested prior to determination of the method of reconsruction of the pharyngoesophagus. In selected cases without previous radiotherapy the laryngotracheal autograft has proved satisfactory.

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