Evidence that angiotensin II, endothelins and nitric oxide regulate mitogen-activated protein kinase activity in rat aorta

1998 ◽  
Vol 347 (2-3) ◽  
pp. 337-346 ◽  
Author(s):  
Takao Kubo ◽  
Emi Saito ◽  
Maki Hanada ◽  
Toshie Kambe ◽  
Yukihiko Hagiwara
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Protein Kinase ◽  
Kinase Activity ◽  
Rat Aorta ◽  
Mitogen Activated Protein Kinase ◽  
Protein Kinase Activity ◽  
Mitogen Activated Protein

scholarly journals The effect of short-term oral treatment with omeprazole or pantoprazole on the function of polymorphonuclear neutrophils

2017 ◽  
Vol 95 (6) ◽  
pp. 675-680
Author(s):  
Maja Kostrzewska ◽  
Marzena Garley ◽  
Wioletta Ratajczak-Wrona ◽  
Ewa Jabłońska ◽  
Jacek Jamiołkowski ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase ◽  
Kinase Activity ◽  
Culture Supernatant ◽  
Polymorphonuclear Neutrophils ◽  
Mitogen Activated Protein Kinase ◽  
Protein Kinase Activity ◽  
Short Term ◽  
Nbt Test ◽  
Mitogen Activated Protein

Recent studies report an increased risk of enteric infections in patients treated with proton pump inhibitors (PPIs). Polymorphonuclear neutrophils (PMNs) play a key role in host response to bacterial infection. We evaluated the effect of omeprazole and pantoprazole treatment on the PMN function. Fifteen patients were treated with omeprazole 20 mg daily and 15 patients with pantoprazole 40 mg daily for 7 days. Treatment with omeprazole or pantoprazole had no effect on spontaneous nitroblue tetrazolium (NBT) test results. Significant increase in the percentage of phagocytes in the omeprazole group in stimulated NBT test (by 69%) was found. Treatment with omeprazole or pantoprazole had no effect on nitric oxide (NO) concentration in the PMN culture supernatant and serum, cyclic guanosine monophosphate concentration in the PMN culture supernatant and serum, as well as inducible nitric oxide synthase (iNOS) protein expression and p38 mitogen-activated protein kinase activity in PMNs. In conclusion, treatment with PPI has no effect on NO production and p38 mitogen-activated protein kinase activity in PMNs. Interestingly, short-term treatment with omeprazole but not with pantoprazole enhances PMN reactive oxygen species production.

scholarly journals p38 Mitogen-Activated Protein Kinase Activity Commits Embryonic Stem Cells to Either Neurogenesis or Cardiomyogenesis

Stem Cells ◽  
2006 ◽  
Vol 24 (5) ◽  
pp. 1399-1406 ◽  
Author(s):  
Myriam Aouadi ◽  
Frédéric Bost ◽  
Leslie Caron ◽  
Kathiane Laurent ◽  
Yannick Le Marchand Brustel ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Protein Kinase ◽  
Kinase Activity ◽  
Embryonic Stem ◽  
Mitogen Activated Protein Kinase ◽  
Protein Kinase Activity ◽  
Mitogen Activated Protein
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