scholarly journals An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors

FEBS Letters ◽  
2001 ◽  
Vol 496 (2-3) ◽  
pp. 109-116 ◽  
Author(s):  
Meng Ling Choong ◽  
Li Kiang Tan ◽  
Siaw Ling Lo ◽  
Ee-Chee Ren ◽  
Keli Ou ◽  
...  
Keyword(s):  
Nuclear Protein ◽  
Integrated Approach ◽  
Pancreatic Tumors

Learning Through Processing: Toward an Integrated Approach to Early Word Learning

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Stephan C. Meylan ◽  
Elika Bergelson
Keyword(s):  
Word Learning ◽  
Empirical Work ◽  
Integrated Approach ◽  
Linguistic Knowledge ◽  
Annual Review ◽  
Publication Date ◽  
Learning Mechanisms ◽  
Lexical Knowledge ◽  
Novel Word Learning

Children's linguistic knowledge and the learning mechanisms by which they acquire it grow substantially in infancy and toddlerhood, yet theories of word learning largely fail to incorporate these shifts. Moreover, researchers’ often-siloed focus on either familiar word recognition or novel word learning limits the critical consideration of how these two relate. As a step toward a mechanistic theory of language acquisition, we present a framework of “learning through processing” and relate it to the prevailing methods used to assess children's early knowledge of words. Incorporating recent empirical work, we posit a specific, testable timeline of qualitative changes in the learning process in this interval. We conclude with several challenges and avenues for building a comprehensive theory of early word learning: better characterization of the input, reconciling results across approaches, and treating lexical knowledge in the nascent grammar with sufficient sophistication to ensure generalizability across languages and development. Expected final online publication date for the Annual Review of Linguistics, Volume 8 is January 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Olf-1-binding site: characterization of an olfactory neuron-specific promoter motif

1993 ◽  
Vol 13 (5) ◽  
pp. 3002-3014
Author(s):  
K Kudrycki ◽  
C Stein-Izsak ◽  
C Behn ◽  
M Grillo ◽  
R Akeson ◽  
...  
Keyword(s):  
Nuclear Protein ◽  
Consensus Sequence ◽  
Binding Motif ◽  
Sequence Motif ◽  
Olfactory Neuron ◽  
Sequence Motifs ◽  
Mobility Shift ◽  
Specific Expression ◽  
Mobility Shift Assay

We report characterization of several domains within the 5' flanking region of the olfactory marker protein (OMP) gene that may participate in regulating transcription of this and other olfactory neuron-specific genes. Analysis by electrophoretic mobility shift assay and DNase I footprinting identifies two regions that contain a novel sequence motif. Interactions between this motif and nuclear proteins were detected only with nuclear protein extracts derived from olfactory neuroepithelium, and this activity is more abundant in olfactory epithelium enriched in immature neurons. We have designated a factor(s) involved in this binding as Olf-1. The Olf-1-binding motif consensus sequence was defined as TCCCC(A/T)NGGAG. Studies with transgenic mice indicate that a 0.3-kb fragment of the OMP gene containing one Olf-1 motif is sufficient for olfactory tissue-specific expression of the reporter gene. Some of the other identified sequence motifs also interact specifically with olfactory nuclear protein extracts. We propose that Olf-1 is a novel, olfactory neuron-specific trans-acting factor involved in the cell-specific expression of OMP.

scholarly journals Characterization of a Nuclear Protein Conferring Brefeldin A Resistance inSchizosaccharomyces pombe

1996 ◽  
Vol 271 (15) ◽  
pp. 9166-9171 ◽  
Author(s):  
Thomas G. Turi ◽  
Ulrich W. Mueller ◽  
Shelley Sazer ◽  
John K. Rose
Keyword(s):  
Nuclear Protein ◽  
Brefeldin A

Immunohistochemical characterization of pancreatic tumors induced by DMBA in rats

1998 ◽  
Vol 114 ◽  
pp. A472
Author(s):  
R.E. Jimenez ◽  
K. Z'graggen ◽  
A.L. Warshaw ◽  
F. Graeme-Cook ◽  
W. Hartwig ◽  
...  
Keyword(s):  
Pancreatic Tumors

scholarly journals Isolation of monoclonal antibodies specific for products of avian oncogene myb.

1984 ◽  
Vol 4 (12) ◽  
pp. 2843-2850 ◽  
Author(s):  
G I Evan ◽  
G K Lewis ◽  
J M Bishop
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Nuclear Protein ◽  
Gene Products ◽  
Viral Oncogenes ◽  
Myb Gene

We isolated a series of monoclonal antibodies which were raised against a bacterially expressed protein, bp37v-myb, and coded for by part of the avian v-myb gene. These monoclonal antibodies recognized a range of antigenic specificities on bp37v-myb, and this was reflected in their differing specificities for the gene products of the v-myb, c-myb, and E26 viral oncogenes. One monoclonal antibody recognized, in addition to the v-myb and c-myb gene products, a conserved nuclear protein found in all tested cells. We describe the characterization of these monoclonal antibodies.

Improved Characterization of Carbonate Rock Properties: A Multiphysics Integrated Approach

2016 ◽  
Author(s):  
Ghazi M. Kraishan ◽  
Shouxiang Mark Ma ◽  
Evgeny Dyshlyuk ◽  
Salah M. Al-Ofi ◽  
Andrea Valori ◽  
...  
Keyword(s):  
Carbonate Rock ◽  
Integrated Approach ◽  
Rock Properties

scholarly journals The Evolution of Economic Research Strategies: The Role of the Concept of Strategizing V. L. Kvint

2021 ◽  
pp. 139-149
Author(s):  
T. A. Alаbinа
Keyword(s):  
System Analysis ◽  
Integrated Approach ◽  
Economic Research ◽  
Scientific School ◽  
Research Strategies ◽  
Research School ◽  
Key Characteristics ◽  
Academy Of Sciences

The two-part series of articles reveals the purpose of the research as determining the place of the concept of strategizing of a Foreign Member of the Russian Academy of Sciences – Academician, Doctor of Economics, Professor V. L. Kvint in the system of economic research of strategies abroad, in the USSR and modern Russia on the basis of the description of the content and systematization of the basic concepts of strategizing and a review of foreign and domestic regional economic research, as well as the author’s identification of the key characteristics of this scientific school of strategy.The object of the research is the theory of strategies abroad, in the USSR and modern Russia. The subject of the research is the concept of V. L. Kvint’s strategizing in the system of economic research on strategy.The methodological tools include techniques and methods of system analysis, comparative analysis, logical analysis, principles of the dialectical-materialistic method of cognition and an integrated approach to the characterization of economic research, methods of generalization and concretization. The description of the study uses a historical approach and a temporary generalization based on the key milestones in the development of economic research on the theory of strategy and the methodology and practice of strategizing.As the results of present article, the main characteristics, systematization and content aspects of foreign and domestic economic research strategies are presented. The place of V. L. Kvint’s concept of strategizing in the system of economic research are determined. The article shows the practice of strategizing the research school.

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