scholarly journals Functional characterization of podocan, a member of a new class in the small leucine-rich repeat protein family

FEBS Letters ◽  
2004 ◽  
Vol 563 (1-3) ◽  
pp. 69-74 ◽  
Author(s):  
Ryoko Shimizu-Hirota ◽  
Hiroyuki Sasamura ◽  
Mari Kuroda ◽  
Emi Kobayashi ◽  
Takao Saruta
Keyword(s):  
Functional Characterization ◽  
Protein Family ◽  
Leucine Rich Repeat ◽  
Repeat Protein ◽  
New Class ◽  
Leucine Rich Repeat Protein

Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins

2012 ◽  
Vol 40 (5) ◽  
pp. 1052-1057 ◽  
Author(s):  
Shani Bialik ◽  
Adi Kimchi
Keyword(s):  
Protein Kinase ◽  
Kinase Activity ◽  
Functional Characterization ◽  
Leucine Rich Repeat ◽  
New Paradigm ◽  
Gtp Binding ◽  
Death Associated Protein Kinase ◽  
In Cis ◽  
Leucine Rich Repeat Protein

DAPK (death-associated protein kinase) is a newly recognized member of the mammalian family of ROCO proteins, characterized by common ROC (Ras of complex proteins) and COR (C-terminal of ROC) domains. In the present paper, we review our recent work showing that DAPK is functionally a ROCO protein; its ROC domain binds and hydrolyses GTP. Furthermore, GTP binding regulates DAPK catalytic activity in a novel manner by enhancing autophosphorylation on inhibitory Ser308, thereby promoting the kinase ‘off’ state. This is a novel mechanism for in cis regulation of kinase activity by the distal ROC domain. The functional similarities between DAPK and the Parkinson's disease-associated protein LRRK2 (leucine-rich repeat protein kinase 2), another member of the ROCO family, are also discussed.

scholarly journals Characterization of a novel anther-specific gene encoding a leucine-rich repeat protein in petunia

2014 ◽  
Vol 13 (4) ◽  
pp. 9889-9898 ◽  
Author(s):  
Y.Z. Yue ◽  
J. Sun ◽  
X. Huang ◽  
H. Peng ◽  
G.F. Liu ◽  
...  
Keyword(s):  
Specific Gene ◽  
Leucine Rich Repeat ◽  
Gene Encoding ◽  
Repeat Protein ◽  
Leucine Rich Repeat Protein

Brief Report: Distinct Dysregulation of the Small Leucine‐Rich Repeat Protein Family in Osteoarthritic Acetabular Labrum Compared to Articular Cartilage

2015 ◽  
Vol 67 (2) ◽  
pp. 435-441 ◽  
Author(s):  
Nele Juchtmans ◽  
Aad A. M. Dhollander ◽  
Julie Coudenys ◽  
Emmanuel A. Audenaert ◽  
Christophe Pattyn ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Protein Family ◽  
Leucine Rich Repeat ◽  
Acetabular Labrum ◽  
Repeat Protein ◽  
Leucine Rich Repeat Protein

scholarly journals Nephrocan, a Novel Member of the Small Leucine-rich Repeat Protein Family, Is an Inhibitor of Transforming Growth Factor-β Signaling

2006 ◽  
Vol 281 (47) ◽  
pp. 36044-36051 ◽  
Author(s):  
Yoshiyuki Mochida ◽  
Duenpim Parisuthiman ◽  
Masaru Kaku ◽  
Jun-ichi Hanai ◽  
Vikas P. Sukhatme ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Protein Family ◽  
Leucine Rich Repeat ◽  
Repeat Protein ◽  
Leucine Rich Repeat Protein
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