Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts

FEBS Letters ◽  
1997 ◽  
Vol 408 (3) ◽  
pp. 289-291 ◽  
Author(s):  
Lars-Oliver Klotz ◽  
Karlis Briviba ◽  
Helmut Sies
Keyword(s):  
Singlet Oxygen ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Uva Radiation

scholarly journals Singlet oxygen induces collagenase expression in human skin fibroblasts

FEBS Letters ◽  
1993 ◽  
Vol 331 (3) ◽  
pp. 304-306 ◽  
Author(s):  
Karin Scharffetter-Kochanek ◽  
Meinhard Wlaschek ◽  
Karlis Briviba ◽  
Helmut Sies
Keyword(s):  
Singlet Oxygen ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts

The Effects of Baicalin Against UVA-Induced Photoaging in Skin Fibroblasts

2014 ◽  
Vol 42 (03) ◽  
pp. 709-727 ◽  
Author(s):  
Wei Min ◽  
Xin Liu ◽  
Qihong Qian ◽  
Bingjiang Lin ◽  
Di Wu ◽  
...  
Keyword(s):  
Protein Expression ◽  
Telomere Length ◽  
Human Skin ◽  
Human Fibroblasts ◽  
Underlying Mechanism ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Uva Irradiation ◽  
Anti Oxidant ◽  
Uva Radiation

Ultraviolet A (UVA) radiation contributes to skin photoaging. Baicalin, a plant-derived flavonoid, effectively absorbs UV rays and has been shown to have anti-oxidant and anti-inflammatory properties that may delay the photoaging process. In the current study, cultured human skin fibroblasts were incubated with 50 μg/ml baicalin 24 hours prior to 10 J/cm2UVA irradiation. In order to examine the efficacy of baicalin treatment in delaying UVA-induced photoaging, we investigated aging-related markers, cell cycle changes, anti-oxidant activity, telomere length, and DNA damage markers. UVA radiation caused an increased proportion of β-Gal positive cells and reduced telomere length in human skin fibroblasts. In addition, UVA radiation inhibited TGF-β1 secretion, induced G1 phase arrest, reduced SOD and GSH-Px levels, increased MDA levels, enhanced the expression of MMP-1, TIMP-1, p66, p53, and p16 mRNA, reduced c-myc mRNA expression, elevated p53 and p16 protein expression, and reduced c-myc protein expression. Baicalin treatment effectively protected human fibroblasts from these UVA radiation-induced aging responses, suggesting that the underlying mechanism involves the inhibition of oxidative damage and regulation of the expression of senescence-related genes, including those encoding for p53, p66Shcand p16.

Thiols and selenium: protective effect on human skin fibroblasts exposed to UVA radiation

1997 ◽  
Vol 40 (1) ◽  
pp. 84-90 ◽  
Author(s):  
N. Emonet ◽  
M.T. Leccia ◽  
A. Favier ◽  
J.C. Beani ◽  
M.J. Richard
Keyword(s):  
Protective Effect ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Uva Radiation

Involvement of singlet oxygen in ultraviolet A-induced lipid peroxidation in cultured human skin fibroblasts

1995 ◽  
Vol 287 (3-4) ◽  
pp. 338-340 ◽  
Author(s):  
F. Gaboriau ◽  
N. Demoulins-Giacco ◽  
I. Tirache ◽  
P. Morli�re
Keyword(s):  
Lipid Peroxidation ◽  
Singlet Oxygen ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Ultraviolet A

scholarly journals Development of Refractoriness of HO-1 Induction to a Second Treatment with UVA Radiation and the Involvement of Nrf2 in Human Skin Fibroblasts

2014 ◽  
Vol 90 (6) ◽  
pp. 1340-1348 ◽  
Author(s):  
Julia Li Zhong ◽  
Chintan M. Raval ◽  
Muhammad Farrukh Nisar ◽  
ChunXiang Bian ◽  
Jin Zhang ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Uva Radiation

Kinetics of singlet oxygen photosensitization in human skin fibroblasts

2008 ◽  
Vol 44 (11) ◽  
pp. 1926-1934 ◽  
Author(s):  
Ana Jiménez-Banzo ◽  
M. Luisa Sagristà ◽  
Margarita Mora ◽  
Santi Nonell
Keyword(s):  
Singlet Oxygen ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Kinetics Of
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