scholarly journals Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 ◽  
Vol 86 (1) ◽  
pp. 99-103 ◽  
Author(s):  
S. M. Keyse ◽  
R. M. Tyrrell
Keyword(s):  
Hydrogen Peroxide ◽  
Human Skin ◽  
Heme Oxygenase ◽  
Sodium Arsenite ◽  
Stress Protein ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Uva Radiation

scholarly journals Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblasts

2014 ◽  
Vol 394 (1-2) ◽  
pp. 217-224 ◽  
Author(s):  
Anna Galicka ◽  
Rafał Krętowski ◽  
Jolanta Nazaruk ◽  
Marzanna Cechowska-Pasko
Keyword(s):  
Hydrogen Peroxide ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Collagen Metabolism ◽  
Human Skin Fibroblasts ◽  
Induced Apoptosis

A role for Nrf2 in UVA-mediated heme oxygenase induction and protection from membrane damage in human skin fibroblasts

2010 ◽  
Author(s):  
Haibin Li ◽  
Linhao Li ◽  
Linhong Deng ◽  
Gurinder Singh ◽  
Rex M. Tyrrell ◽  
...  
Keyword(s):  
Human Skin ◽  
Heme Oxygenase ◽  
Membrane Damage ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts

Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts

FEBS Letters ◽  
1997 ◽  
Vol 408 (3) ◽  
pp. 289-291 ◽  
Author(s):  
Lars-Oliver Klotz ◽  
Karlis Briviba ◽  
Helmut Sies
Keyword(s):  
Singlet Oxygen ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Uva Radiation

The Effects of Baicalin Against UVA-Induced Photoaging in Skin Fibroblasts

2014 ◽  
Vol 42 (03) ◽  
pp. 709-727 ◽  
Author(s):  
Wei Min ◽  
Xin Liu ◽  
Qihong Qian ◽  
Bingjiang Lin ◽  
Di Wu ◽  
...  
Keyword(s):  
Protein Expression ◽  
Telomere Length ◽  
Human Skin ◽  
Human Fibroblasts ◽  
Underlying Mechanism ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Uva Irradiation ◽  
Anti Oxidant ◽  
Uva Radiation

Ultraviolet A (UVA) radiation contributes to skin photoaging. Baicalin, a plant-derived flavonoid, effectively absorbs UV rays and has been shown to have anti-oxidant and anti-inflammatory properties that may delay the photoaging process. In the current study, cultured human skin fibroblasts were incubated with 50 μg/ml baicalin 24 hours prior to 10 J/cm2UVA irradiation. In order to examine the efficacy of baicalin treatment in delaying UVA-induced photoaging, we investigated aging-related markers, cell cycle changes, anti-oxidant activity, telomere length, and DNA damage markers. UVA radiation caused an increased proportion of β-Gal positive cells and reduced telomere length in human skin fibroblasts. In addition, UVA radiation inhibited TGF-β1 secretion, induced G1 phase arrest, reduced SOD and GSH-Px levels, increased MDA levels, enhanced the expression of MMP-1, TIMP-1, p66, p53, and p16 mRNA, reduced c-myc mRNA expression, elevated p53 and p16 protein expression, and reduced c-myc protein expression. Baicalin treatment effectively protected human fibroblasts from these UVA radiation-induced aging responses, suggesting that the underlying mechanism involves the inhibition of oxidative damage and regulation of the expression of senescence-related genes, including those encoding for p53, p66Shcand p16.

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