Contraceptive efficacy and safety studies of a novel microemulsion-based lipophilic vaginal spermicide

2001 ◽  
Vol 75 (1) ◽  
pp. 115-124 ◽  
Author(s):  
Osmond J D’Cruz ◽  
Seang H Yiv ◽  
Barbara Waurzyniak ◽  
Fatih M Uckun
Keyword(s):  
Efficacy And Safety ◽  
Contraceptive Efficacy ◽  
Safety Studies

scholarly journals Pharmacogenetics in drug development

2005 ◽  
Vol 360 (1460) ◽  
pp. 1579-1588 ◽  
Author(s):  
Alun D McCarthy ◽  
James L Kennedy ◽  
Lefkos T Middleton
Keyword(s):  
Pharmaceutical Companies ◽  
Efficacy And Safety ◽  
Plasma Drug ◽  
Dose Selection ◽  
Drug Discovery And Development ◽  
Safety Issues ◽  
Drug Choice ◽  
Probability Of Success ◽  
Safety Studies ◽  
Appropriate Therapy

Over the last two decades, identification of polymorphisms that influence human diseases has begun to have an impact on the provision of medical care. The promise of genetics lies in its ability to provide insights into an individual's susceptibility to disease, the likely nature of the disease and the most appropriate therapy. For much of its history, pharmacogenetics (PGx—the use of genetic information to impact drug choice) has been limited to comparatively simple phenotypes such as plasma drug levels. Progress in genetics technologies has broadened the scope of PGx efficacy and safety studies that can be implemented, impacting on a broad spectrum of drug discovery and development activities. Recent PGx data show the ability of this approach to generate information that can be applied to dose selection, efficacy determination and safety issues. This in turn will lead to significant opportunities to affect both the approach to clinical development and the probability of success—the latter being an important aspect for pharmaceutical companies and for the patients who will benefit from these new medicines.

scholarly journals 793Validation of cardiac optogenetics against patch clamp electrophysiology in human cardiomyocyte drug efficacy and safety studies

EP Europace ◽  
2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii141-iii141
Author(s):  
S. Bjork ◽  
E. Ojala ◽  
T. Nordstrom ◽  
E. Kankuri ◽  
E. Mervaala
Keyword(s):  
Patch Clamp ◽  
Drug Efficacy ◽  
Efficacy And Safety ◽  
Safety Studies ◽  
Patch Clamp Electrophysiology

scholarly journals Vaccines against SARS CoV 2 and the vaccination campaign in Italy

2021 ◽  
Vol 24 (2) ◽  
pp. 137
Author(s):  
Ponziani, M.C.
Keyword(s):  
Viral Genome ◽  
Viral Vector ◽  
Vaccination Campaign ◽  
Spike Protein ◽  
Effective Vaccine ◽  
Efficacy And Safety ◽  
Thrombotic Risk ◽  
Safety Studies ◽  
Key Words Vaccination ◽  
Number Of Individuals

The SARS COV 2 pandemic has created an unprecedented need to manufacture and distribute a safe and effective vaccine to immunize an exceptionally large number of individuals planning diversified vaccination approaches quickly. A few weeks have passed since the sequencing of the viral genome for the design of the first vaccines and a few months for the implementation of the efficacy and safety studies. The article analyzes the types of vaccines available by examining their characteristics, efficacy and safety, also examining some debated issues such as the thrombotic risk of viral vector vaccines. The second part deals with the issue of the vaccination campaign in our country. KEY WORDS vaccination; COVID-19; spike protein; efficacy; safety.

Contraceptive Efficacy and Safety of 52 mg LNG-IUS for up to Eight Years

2020 ◽  
Vol 135 ◽  
pp. 6S ◽  
Author(s):  
Jeffrey T. Jensen ◽  
Robin Kroll ◽  
Richard F. Lynen ◽  
Andrea Schulze ◽  
Eeva Lukkari-Lax
Keyword(s):  
Efficacy And Safety ◽  
Contraceptive Efficacy
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