P-301 Oocytes with opaque cytoplasm have reduced fertilization and cleavage rates without a significant impact on clinical pregnancy rates

IntroductionA trial or mock embryo transfer (ET) may influence pregnancy rates and it performed prior to ET allows the clinician to assess the uterine cavity and the utero-cervical angle. The aim of this study is to compare the consistency of the type of ET in mock ET with real ET.Material & MethodsA retrospective comparative analysis of patients who underwent in vitro fertilization or ICSI cycle from January 2014 to December 2014 in Halim Fertility Center was done. The type of transfer was divided into two groups: ‘easy’ or ‘difficult’. An easy ET was defined as a transfer that occurred without the use of manipulation or other instrumentation and difficult ET was considered when additional instrumentation was required.ResultsFrom the study, 103 patients who underwent Mock-ET, we found 58 patients (56.3%) with easy ET and 45 patients (43.7%) with difficult ET, which with hard catheter ET in 17 patients (16.5%), with osfander assistance in 20 patients (19.4%) and with stylet in 8 patients (7,8%). 58 patients with Easy Mock ET group were entirely easy real ET (100%) and 45 patients with difficult Mock ET group also entirely were difficult real ET (100%). The Statistical analysis shows no significant difference between the mock ET and real ET groups (p>0,05). In easy real ET, clinical pregnancy rates were 32.8% and in difficult real ET, clinical pregnancy rates were 26.7% with no significant difference between the groups (p>0,05).Conclusion:Mock ET prior to the treatment cycle is consistent with real ET.

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Effects of human chorionic gonadotropin intrauterine injection on oocyte retrieval day on assisted reproductive techniques outcomes: An RCT

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v19i9.9709 ◽

2021 ◽

pp. 773-780

Author(s):

Robabe Hosseinisadat ◽

Lida Saeed ◽

Sareh Ashourzadeh ◽

Sedigheh Safar Heidari ◽

Victoria Habibzadeh

Keyword(s):

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Oocyte Retrieval ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Assisted Reproductive Techniques ◽

Control Group ◽

Case Group ◽

Reproductive Techniques ◽

Clinical Pregnancy Rates

Background: Several mediators play an important role in implantation. One of these mediators is human chorionic gonadotropin (HCG). Objective: To evaluate the effects of HCG intrauterine injection on the day of oocyte retrieval on the result of assisted reproductive techniques (ART). Materials and Methods: In this randomized clinical trial study, 126 women who were referred to Afzalipour Infertility Center between December 2018 to December 2019 undergoing in vitro fertilization/intracytoplasmic sperm injection cycles were enrolled and assigned to two groups of: a case (n = 62) and a control group (n = 64). The protocols for both groups were the same; except that the case group was injected with the protocols for both groups were the same, except that the case group was injected with 1000 IU of HCG into uterine cavity following the oocyte puncture, while no medication was administered to the control group. The implantation rate, chemical pregnancy, clinical pregnancy, and abortion rates were compared between the two groups. Results: Positive chemical pregnancy was seen in 15 (27.3%) cases of the case group and 14 (25.5%) of the control group. No significant difference was seen in the chemical and clinical pregnancy rates between the groups. The abortion rate was higher in the control group but that was not significant. Conclusion: A 1000 IU of HCG intrauterine injection after oocyte retrieval does not improve implantation, chemical or clinical pregnancy rates in ART cycles. Further studies are needed to clearly understand the role of HCG intrauterine injection in the day of oocyte retrieval in ART outcomes. Key words: Oocyte retrieval, Chorionic gonadotropin, Pregnancy, Assisted reproductive techniques.

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The effect of low-dose aspirin on the pregnancy rate in frozen-thawed embryo transfer cycles: A randomized clinical trial

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v13i9.7664 ◽

2020 ◽

Author(s):

Robab Davar ◽

Soheila Pourmasumi ◽

Banafsheh Mohammadi ◽

Maryam Mortazavi Lahijani

Keyword(s):

Clinical Trial ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Low Dose ◽

Endometrial Thickness ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Dose Aspirin ◽

Low Dose Aspirin ◽

Clinical Pregnancy Rates

Background: The results of previous studies on the effect of low-dose aspirin in frozenthawed embryo transfer (FET) cycles are limited and controversial. Objective: To evaluate the effect of low-dose aspirin on the clinical pregnancy in the FET cycles. Materials and Methods: This study was performed as a randomized clinical trial from May 2018 to February 2019; 128 women who were candidates for the FET were randomly assigned to two groups receiving either 80 mg oral aspirin (n = 64) or no treatment. The primary outcome was clinical pregnancy rate and secondary outcome measures were the implantation rate, miscarriage rate, and endometrial thickness. Results: The endometrial thickness was lower in patients who received aspirin in comparison to the control group. There were statistically significant differences between the two groups (p = 0.018). Chemical and clinical pregnancy rates and abortion rate was similar in the two groups and there was no statistically significant difference. Conclusion: The administration of aspirin in FET cycles had no positive effect on the implantation and the chemical and clinical pregnancy rates, which is in accordance with current Cochrane review that does not recommend aspirin administration as a routine in assisted reproductive technology cycles. Key words: Aspirin, Embryo transfer, Pregnancy rates.

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LASER-ASSISTED HATCHING ON DAY 1 OF EMBRYO CULTURE DEMONSTRATES EQUIVALENT ONGOING CLINICAL PREGNANCY RATES COMPARED TO EMBRYOS WITH STANDARD DAY 3 ASSISTED HATCHING

Fertility and Sterility ◽

10.1016/j.fertnstert.2021.07.1185 ◽

2021 ◽

Vol 116 (3) ◽

pp. e148

Author(s):

Elizabeth A. Dilday ◽

Lindsay Kroener ◽

Alin Lina Akopians ◽

Nasario E. Ramos ◽

Naomi Xu ◽

...

Keyword(s):

Embryo Culture ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Assisted Hatching ◽

Clinical Pregnancy Rates

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Serum progesterone levels on the day of hCG trigger and ICSI outcome: a retrospective observational cohort study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20183316 ◽

2018 ◽

Vol 7 (8) ◽

pp. 3194 ◽

Cited By ~ 2

Author(s):

Kinnari Vilaschandra Amin ◽

Purnima Nadkarni ◽

Pooja Nadkarni Singh ◽

Prabhakar Singh

Keyword(s):

Cohort Study ◽

Oocyte Quality ◽

Observational Cohort Study ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Serum Progesterone ◽

Observational Cohort ◽

Clinical Pregnancy Rates ◽

Β Hcg ◽

Hcg Trigger

Background: Whether serum progesterone (P4) level on the day of human chorionic gonadotropin (hCG) trigger is related to the outcome of artificial reproductive technology (ART) is still a debatable issue. The objective of this study was to evaluate relationship between serum Progesterone levels on the day of hCG trigger and ICSI outcome.Method: This was a retrospective, non-interventional, observational, cohort study of patients undergoing ICSI at 21st Century Group of Hospitals, Killa Pardi and Surat, Gujarat during the period of January 2018 to March 2018. Patients with age group of 20-40 years who underwent ICSI-ET using GnRH antagonist flexible protocol during this period, had obtained 2 or more MII oocytes during retrieval and had at least one grade I embryo transferred were included in this study. Women using donor oocytes were excluded. Serum progesterone levels were analysed on day of hCG trigger. Total 165 patients were included in the study. They were divided into two groups, those with β-hCG less than or equal to 1.5 ng/ml and those with β-hCG more than 1.5 ng/ml. Student's t test and Chi square test were used to compare the clinical pregnancy rates between two groups.Results: Clinical pregnancy rate decreases with increase in serum progesterone levels on the day of hCG trigger. Patients with serum progesterone levels ≤1.5 ng/ml had significantly higher clinical pregnancy rates than those with progesterone levels >1.5 ng/ml (45% vs 6%; p :<0.001).Conclusion: Pre-hCG rise in serum Progesterone concentration does not affect the oocyte quality. But, it significantly decreases the chances of implantation and the clinical pregnancy rates.

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