scholarly journals Effects of human chorionic gonadotropin intrauterine injection on oocyte retrieval day on assisted reproductive techniques outcomes: An RCT

2021 ◽  
pp. 773-780
Author(s):  
Robabe Hosseinisadat ◽  
Lida Saeed ◽  
Sareh Ashourzadeh ◽  
Sedigheh Safar Heidari ◽  
Victoria Habibzadeh
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Oocyte Retrieval ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Assisted Reproductive Techniques ◽  
Control Group ◽  
Case Group ◽  
Reproductive Techniques ◽  
Clinical Pregnancy Rates

Background: Several mediators play an important role in implantation. One of these mediators is human chorionic gonadotropin (HCG). Objective: To evaluate the effects of HCG intrauterine injection on the day of oocyte retrieval on the result of assisted reproductive techniques (ART). Materials and Methods: In this randomized clinical trial study, 126 women who were referred to Afzalipour Infertility Center between December 2018 to December 2019 undergoing in vitro fertilization/intracytoplasmic sperm injection cycles were enrolled and assigned to two groups of: a case (n = 62) and a control group (n = 64). The protocols for both groups were the same; except that the case group was injected with the protocols for both groups were the same, except that the case group was injected with 1000 IU of HCG into uterine cavity following the oocyte puncture, while no medication was administered to the control group. The implantation rate, chemical pregnancy, clinical pregnancy, and abortion rates were compared between the two groups. Results: Positive chemical pregnancy was seen in 15 (27.3%) cases of the case group and 14 (25.5%) of the control group. No significant difference was seen in the chemical and clinical pregnancy rates between the groups. The abortion rate was higher in the control group but that was not significant. Conclusion: A 1000 IU of HCG intrauterine injection after oocyte retrieval does not improve implantation, chemical or clinical pregnancy rates in ART cycles. Further studies are needed to clearly understand the role of HCG intrauterine injection in the day of oocyte retrieval in ART outcomes. Key words: Oocyte retrieval, Chorionic gonadotropin, Pregnancy, Assisted reproductive techniques.

scholarly journals Comparison of pregnancy outcome in intrauterine insemination-candidate women with and without endometrial scratch injury: An RCT

2021 ◽  
Author(s):  
Mahnaz Yavangi ◽  
Nesa Varmaghani ◽  
Azar Pirdehghan ◽  
Maryam Varmaghani ◽  
Mohammad Faryadras
Keyword(s):  
Intrauterine Insemination ◽  
Live Birth Rate ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Control Group ◽  
Case Group ◽  
Multiple Gestation ◽  
Endometrial Scratch ◽  
Clinical Pregnancy Rates ◽  
And Control

Background: Endometrial scratch injury is considered controversial in increasing the success rate of assisted reproductive technology. Objective: To compare the pregnancy outcomes in women undergoing intrauterine insemination with and without an endometrial scratch. Materials and Methods: In this randomized clinical trial, 150 women referred to the Fatemieh Hospital, Hamadan, Iran who were candidates for IUI between December 2017 and December 2018 were randomly assigned into two groups (n = 75/each) with or without an endometrial scratch (as case and control groups, respectively). Women in both groups were in proper and identical protocol for IUI. Chemical and clinical pregnancies, abortion, and live birth rate, also pregnancy complications were compared between the groups. Results: Chemical and clinical pregnancy rates were higher in the case than the control group (p = 0.25, p = 0.54, respectively). In the case group, the abortion and multiple gestation rates were 14.3% and 4.3%, respectively, while it was 5% in the control group (p = 0.60, p = 0.54 respectively). The endometrium thickness on day 21 was higher in the case group than the control (p = 0.01). Conclusion: Endometrial scratching in intrauterine insemination women is not associated with an increase in both clinical and clinical pregnancy rates, however, studies with a larger sample size are recommended to evaluate this intervention. Key words: Pregnancy infertility, Women, Endometrial injury, Pregnancy, Intrauterine insemination.

scholarly journals Effect of Total versus Partial Assisted Hatching on the Clinical Pregnancy Rates in Assisted Reproduction Technology

2018 ◽  
pp. 1
Author(s):  
Bulent Emre Bilgic ◽  
Enis Ozkaya ◽  
Cigdem Yayla Abide ◽  
Semra Kayatas Eser ◽  
Ilhan Sanverdi ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Control Group ◽  
Assisted Hatching ◽  
Assisted Reproduction Technology ◽  
Stage Embryo ◽  
Clinical Pregnancy Rates ◽  
Control Study

<p><strong>Objective:</strong> The objective of this study was to investigate the effect of total or partial assisted hatching on the clinical pregnancy rates in assisted reproduction technology.</p><p><strong>Study Design:</strong> This was a case-control study conducted from the beginning of January 2016 to the end of June 2017. A total of 404 cycles were included in this case-control study. Study population was divided into 3 groups: Group 1: Partial assisted hatching (n=118), Group 2: Total assisted hatching (n=81) and Control group (n=205).</p><p><strong>Results:</strong> In women of all ages, clinical pregnancy rates were similar between groups with total or partial assisted hatching compared to control group (p&gt;0.05). The rates were also similar in subgroups of women with blastocyst or cleavage stage embryo transfers (p&gt;0.05). Partial or total embryo hatching did not result in favorable outcome compared to control group either in women over 35 or younger than 35 years of age (p&gt;0.05). In whole study group pregnancy rate was significantly higher in group with blastocyst stage embryo transfers (22.4 % versus 48.8%, p&lt;0.05)</p><p><strong>Conclusion:</strong> Partial or total assisted hatching do not have any impact on the clinical pregnancy rates, no significant impact was determined in subgroup of women either.</p>

scholarly journals Comparison of Cycle Outcomes Among Women with Endometrioma or Non-Functional Cysts Versus Control

2021 ◽  
pp. 1-6
Author(s):  
Enis Ozkaya ◽  
Ebru Cogendez ◽  
Elif Tozkir ◽  
Saadet Unsal ◽  
Ahmet Yavuz ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cystic Mass ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Control Group ◽  
Vitro Fertilization ◽  
Clinical Pregnancy Rates ◽  
And Control ◽  
Cycle Outcome

OBJECTIVE: This study aimed to compare cycle outcomes among women with endometrioma or non-functional cysts versus control. STUDY DESIGN: Women under 35 years of age with unexplained infertility underwent in vitro fertilization cycle. Two hundred and ninety-nine women were included in this study. Study groups consist of women with endometrioma (n=82) or non-functional ovarian cysts (n=100) and control group (n=117). Women in each group were selected consecutively. Groups were matched for age and ovarian reserve and compared in terms of in vitro fertilization cycle outcome. RESULTS: There were no significant differences among groups in terms of mean age, early follicular phase Follicle-Stimulating Hormone, and anti-müllerian hormone levels (p>0.05). Baseline total antral follicle counts were similar among groups (p>0.05). There were significant differences among groups in terms of mean starting and total gonadotropin dose, peak estradiol level, total oocyte number, and mature oocyte numbers (p<0.05). Clinical pregnancy rates were 10.7%, 17.3%, and 31.6% in groups with non-functional cyst, endometrioma and control group respectively (p<0.05). The presence of a non-functional cystic mass of ovary on the starting day of stimulation was a risk factor for poor cycle outcome in terms of clinical pregnancy rates [OR=0.5 (95 % CI; 0.2-0.9, p=0.03)]. CONCLUSION: Our data showed that the presence of any kind of cystic mass of the ovary especially the non-functional cysts on the starting day of stimulation was a risk factor for poor cycle outcomes in terms of clinical pregnancy rates.

scholarly journals The ovulatory response to human chorionic gonadotropin administration on day 4 post timed artificial insemination improved fertility in repeat breeder cows

2021 ◽  
Vol 90 (1) ◽  
pp. 15-20
Author(s):  
Gulnaz Yilmazbas-Mecitoglu ◽  
Ahmet Gumen ◽  
Ebru Karakaya-Bilen ◽  
Abdulkadir Keskin ◽  
Baris Guner ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Dairy Cows ◽  
Corpus Luteum ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Artificial Insemination ◽  
Pregnancy Rates ◽  
Control Group ◽  
Timed Artificial Insemination ◽  
Repeat Breeder

This study focused on determining the success of inducing endogenous progesterone source (by formation of accessory corpus luteum) by human chorionic gonadotropin (hCG) administration on day 4 post timed artificial insemination (TAI) and on evaluating the effect of the day of hCG administration (day 4 or 5 post TAI) on pregnancy rates in repeat breeder cows according to their responses to hCG administrations. Non-pregnant cyclic lactating Holstein dairy cows with more than three services despite no clinical reproductive abnormalities were enrolled in the study. All cows (n = 192) received the Ovsynch protocol (GnRH-7d-PGF2α-56h-GnRH-16/18h-TAI) and hCG administration (1500 IU, i.m.) was performed in group hCG4 (n = 64) on day 4 and in group hCG5 (n = 68) on day 5 post TAI. The control group (CON, n = 60) did not receive any hCG treatment. The responses (ovulation rate) to hCG (~64%) were similar on days 4 and 5 post TAI. Pregnancy per AI (P/AI) at 31 days was similar among the groups (48.3% in CON, 48.4% in hCG4, and 42.6% in hCG5). Regardless of the day of the treatment (hCG4 + hCG5), the cows had an ovulatory response to hCG (54.1%), and a greater P/AI (P = 0.007) at 31 days than those without a response (29.8%). The administration of hCG on either day 4 or 5 post TAI did not increase overall pregnancy rates, however, the ovulatory response to the post TAI hCG administration on day 4 improved fertility in repeat breeder cows. Further studies are needed with a larger number of animals to reveal this potentiallly beneficial effect.

171 NORMAL VERSUS LOW ANTI-MULLERIAN HORMONE IN PATIENTS WITH ADVANCED MATERNAL AGE: IN VITRO FERTILIZATION OUTCOMES AND MORPHOKINETIC PARAMETERS

2016 ◽  
Vol 28 (2) ◽  
pp. 216
Author(s):  
A. Kotlyar ◽  
R. Flyckt ◽  
N. Desai
Keyword(s):  
Cell Cycle ◽  
Oocyte Retrieval ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Imaging Data ◽  
Vitro Fertilization ◽  
Ivf Outcomes ◽  
Morphokinetic Parameters ◽  
Clinical Pregnancy Rates

Anti-Mullerian hormone (AMH) levels are often used in an IVF population for assessment of ovarian reserve. However, it is not well understood whether AMH levels predict implantation and clinical pregnancy in older women undergoing IVF. In this study, we sought to compare IVF outcomes and morphokinetic parameters in patients 38 years and older with normal versus low AMH levels. Experimental design was a single-centre, retrospective cohort study. Time-lapse imaging data were evaluated for patients 38 years and older (n = 81). Patients were divided into those with AMH values less than 1.0 (n = 47) versus greater than or equal to 1.0 (n = 34). Morphokinetic data was then analysed from transferred blastocysts from these patients cultured in the Embryoscope until transfer (n = 100). The morphokinetic parameters examined were time to 2 cell (t2), 4 cell(t4), 5 cell (t5), time to synchronous divisions (s2, s3), duration of the second cell cycle (cc2), and third cell cycle (cc3). Implantation and clinical pregnancy were identified based upon the presence of a gestational sac. Fertilization, implantation, clinical pregnancy, and blastocyst formation rates were compared between normal and low AMH groups (Table 1). Mean morphokinetic parameters were compared between the 2 AMH groups using an unpaired t-test. Chi-squared tests were used for proportions. P < 0.05 was considered statistically significant. Results: Age of the patients ranged from 38–43, (41.3 ± 2.2 years). The results are summarised below. There were significant differences between implantation and clinical pregnancy rates for low and normal AMH levels. Morphokinetic parameters among the transferred embryos did not differ significantly between the 2 AMH groups (NS, data not shown). Conclusions: This initial data indicates that, in an IVF population 38 years and older, AMH levels greater than or equal to the cutoff of 1 ng mL–1 are associated not only with increased oocyte retrieval, but also with increased implantation rates and clinical pregnancy rates. These differences suggest that AMH may have a predictive role in determining the likelihood of clinical pregnancy in the 38 years and older patient population. Table 1.Oocyte harvest and IVF outcomes

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