Potentiation of human colon cancer cell apoptotic cell death by inhibition of ceramidase/glucosylceramide synthase

2003 ◽  
Vol 124 (4) ◽  
pp. A598
Author(s):  
Serge Dionne ◽  
Denise Levesque ◽  
Ernest G. Seidman
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Apoptotic Cell ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Apoptotic Cell Death ◽  
Human Colon Cancer Cell ◽  
Glucosylceramide Synthase ◽  
Human Colon Cancer

scholarly journals p53 Is a Key Regulator for Osthole-Triggered Cancer Pathogenesis

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ssu-Ming Huang ◽  
Cheng-Fang Tsai ◽  
Dar-Ren Chen ◽  
Min-Ying Wang ◽  
Wei-Lan Yeh
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Colon ◽  
Cancer Cell Lines ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines

Osthole has been reported to have antitumor activities via the induction of apoptosis and inhibition of cancer cell growth and metastasis. However, the detailed molecular mechanisms underlying the anticancer effects of osthole in human colon cancer remain unclear. In the present study, we have assessed osthole-induced cell death in two different human colon cancer cell lines, HCT116 and SW480. Our results also showed that osthole activated proapoptotic signaling pathways in human colon cancer cells. By using cell culture insert system, osthole reduced cell motility in both human colon cancer cell lines. This study also provides evidence supporting the potential of osthole in p53 activation. Expression of p53, an apoptotic protein, was remarkably upregulated in cells treated with osthole. Importantly, the levels of phosphorylation of p53 on Ser15 (p-p53) and acetylation of p53 on Lys379(acetyl-p53) were increased under osthole treatment. Our results also demonstrated that p53 was activated followed by generation of reactive oxygen species (ROS) and activation of c-Jun N-terminal kinase (JNK). Our study provides novel insights of p53-mediated responses under osthole treatment. Taken together, we concluded that osthole induces cancer cell death and inhibits migratory activity in a controlled manner and is a promising candidate for antitumor drug development.

Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell

2010 ◽  
Vol 288 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Hai-yan Xiong ◽  
Xian-ling Guo ◽  
Xin-xin Bu ◽  
Shan-shan Zhang ◽  
Nan-nan Ma ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Autophagic Cell Death ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer

Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture

2007 ◽  
Vol 43 (2) ◽  
pp. 195-205 ◽  
Author(s):  
Ana García-Navarro ◽  
Cristina González-Puga ◽  
Germaine Escames ◽  
Luis C. López ◽  
Ana López ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Human Colon Cancer Cell ◽  
Cellular Mechanisms ◽  
Human Colon Cancer ◽  
Ht 29

In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I

2005 ◽  
Vol 15 (17) ◽  
pp. 3930-3933 ◽  
Author(s):  
Rosaria Ottanà ◽  
Stefania Carotti ◽  
Rosanna Maccari ◽  
Ida Landini ◽  
Giuseppa Chiricosta ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines
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