M1968 Metformin Disrupts Crosstalk Between G Protein-Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

Signaling Systems ◽

Insulin Receptor Signaling ◽

Metformin Disrupts Crosstalk between G Protein–Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

Cancer Research ◽

10.1158/0008-5472.can-09-0418 ◽

2009 ◽

Vol 69 (16) ◽

pp. 6539-6545 ◽

Cited By ~ 208

Author(s):

Krisztina Kisfalvi ◽

Guido Eibl ◽

James Sinnett-Smith ◽

Enrique Rozengurt

Keyword(s):

Pancreatic Cancer ◽

Insulin Receptor ◽

G Protein ◽

Cancer Growth ◽

Receptor Signaling ◽

Signaling Systems ◽

Insulin Receptor Signaling ◽

Crosstalk Between Insulin Receptor and G Protein-Coupled Receptor Signaling Systems Leads to Ca2+ Oscillations in Pancreatic Cancer PANC-1 Cells

Gastroenterology ◽

10.1016/s0016-5085(11)61993-8 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-483

Author(s):

Steven H. Young ◽

Enrique Rozengurt

Keyword(s):

Pancreatic Cancer ◽

Insulin Receptor ◽

G Protein ◽

Receptor Signaling ◽

Signaling Systems ◽

Crosstalk between insulin receptor and G protein-coupled receptor signaling systems leads to Ca2+ oscillations in pancreatic cancer PANC-1 cells

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2010.09.036 ◽

2010 ◽

Vol 401 (1) ◽

pp. 154-158 ◽

Cited By ~ 16

Author(s):

Steven H. Young ◽

Enrique Rozengurt

Keyword(s):

Pancreatic Cancer ◽

Insulin Receptor ◽

G Protein ◽

Receptor Signaling ◽

Signaling Systems ◽

Crosstalk between Insulin/Insulin-like Growth Factor-1 Receptors and G Protein-Coupled Receptor Signaling Systems: A Novel Target for the Antidiabetic Drug Metformin in Pancreatic Cancer: Fig. 1.

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-09-2229 ◽

2010 ◽

Vol 16 (9) ◽

pp. 2505-2511 ◽

Cited By ~ 162

Author(s):

Enrique Rozengurt ◽

James Sinnett-Smith ◽

Krisztina Kisfalvi

Keyword(s):

Pancreatic Cancer ◽

Growth Factor ◽

G Protein ◽

Insulin Like Growth Factor ◽

Receptor Signaling ◽

Antidiabetic Drug ◽

Signaling Systems ◽

Novel Target ◽

Biased G protein-coupled receptor agonism mediates Neu1 sialidase and matrix metalloproteinase-9 crosstalk to induce transactivation of insulin receptor signaling

Cellular Signalling ◽

10.1016/j.cellsig.2017.12.006 ◽

2018 ◽

Vol 43 ◽

pp. 71-84 ◽

Cited By ~ 15

Author(s):

Fiona Haxho ◽

Sabah Haq ◽

Myron R. Szewczuk

Keyword(s):

Matrix Metalloproteinase ◽

Insulin Receptor ◽

G Protein ◽

Matrix Metalloproteinase 9 ◽

Receptor Signaling ◽

Insulin Receptor Signaling ◽

Neu1 Sialidase ◽

G Protein Coupled ◽

Metalloproteinase 9

Abstract 1790: Investigation of oncogenic G-protein coupled receptor signaling pathways inKrasdependent pancreatic cancer cell lines

10.1158/1538-7445.sabcs18-1790 ◽

2019 ◽

Author(s):

Ozhan Ocal ◽

Raymond MacDonald ◽

Rolf A. Brekken ◽

Thomas Wilkie

Keyword(s):

Pancreatic Cancer ◽

Signaling Pathways ◽

G Protein ◽

Cell Lines ◽

Cancer Cell ◽

Pancreatic Cancer Cell ◽

Cancer Cell Lines ◽

Receptor Signaling ◽

G protein-coupled receptor signaling in human ductal pancreatic cancer cells: Neurotensin responsiveness and mitogenic stimulation

Journal of Cellular Physiology ◽

10.1002/1097-4652(200101)186:1<53::aid-jcp1004>3.0.co;2-q ◽

2000 ◽

Vol 186 (1) ◽

pp. 53-64 ◽

Cited By ~ 53

Author(s):

Nova M. Ryder ◽

Sushovan Guha ◽

Oscar J. Hines ◽

Howard A. Reber ◽

Enrique Rozengurt

Keyword(s):

Pancreatic Cancer ◽

Cancer Cells ◽

G Protein ◽

Receptor Signaling ◽

Mitogenic Stimulation ◽

Pancreatic Cancer Cells ◽

Ductal Pancreatic Cancer ◽

Investigation of oncogenic G‐protein coupled receptor signaling pathways in Kras dependent pancreatic cancer cell lines

The FASEB Journal ◽

10.1096/fasebj.2019.33.1_supplement.647.29 ◽

2019 ◽

Vol 33 (S1) ◽

Author(s):

Ozhan Ocal ◽

Raymond MacDonald ◽

Rolf A. Brekken ◽

Thomas Wilkie

Keyword(s):

Pancreatic Cancer ◽

Signaling Pathways ◽

G Protein ◽

Cell Lines ◽

Cancer Cell ◽

Pancreatic Cancer Cell ◽

Cancer Cell Lines ◽

Receptor Signaling ◽

Abstract 1790: Investigation of oncogenic G-protein coupled receptor signaling pathways inKrasdependent pancreatic cancer cell lines

10.1158/1538-7445.am2019-1790 ◽

2019 ◽

Author(s):

Ozhan Ocal ◽

Raymond MacDonald ◽

Rolf A. Brekken ◽

Thomas Wilkie

Keyword(s):

Pancreatic Cancer ◽

Signaling Pathways ◽

G Protein ◽

Cell Lines ◽

Cancer Cell ◽

Pancreatic Cancer Cell ◽

Cancer Cell Lines ◽

Receptor Signaling ◽

Vanadium compounds cause activation of G protein-coupled receptor signaling

10.1021/scimeetings.0c06853 ◽

2020 ◽

Author(s):

Debbie C. Crans ◽

Duaa Althumairy ◽

Heide Murakami ◽

B. George Barisas ◽

Deborah Roess

Keyword(s):

G Protein ◽

Receptor Signaling ◽

Vanadium Compounds ◽