Abstract 1790: Investigation of oncogenic G-protein coupled receptor signaling pathways inKrasdependent pancreatic cancer cell lines

2019 ◽  
Author(s):  
Ozhan Ocal ◽  
Raymond MacDonald ◽  
Rolf A. Brekken ◽  
Thomas Wilkie
Keyword(s):  
Pancreatic Cancer ◽  
Signaling Pathways ◽  
G Protein ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

The obestatin/G-protein coupled receptor 39 (GPR39) system in pancreatic cancer: proliferation studies in pancreatic cancer cell lines

Pancreatology ◽  
2019 ◽  
Vol 19 ◽  
pp. S162
Author(s):  
Lara Estevez-Perez ◽  
Saul Leal-Lopez ◽  
Vanesa Veloso-Noya ◽  
Begoña Otero-Alen ◽  
Carlos Seoane-Mosteiro ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
G Protein ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines ◽  
G Protein Coupled Receptor ◽  
Cancer Proliferation ◽  
G Protein Coupled

Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines

2003 ◽  
Vol 300 (3) ◽  
pp. 669-673 ◽  
Author(s):  
Yasuhiro Miyagawa ◽  
Hiroshi Ohguro ◽  
Hiroki Odagiri ◽  
Ikuyo Maruyama ◽  
Tadao Maeda ◽  
...  
Keyword(s):  
G Protein ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

Gastrin regulates growth of human pancreatic cancer in a tonic and autocrine fashion

1996 ◽  
Vol 270 (5) ◽  
pp. R1078-R1084 ◽  
Author(s):  
J. P. Smith ◽  
A. Shih ◽  
Y. Wu ◽  
P. J. McLaughlin ◽  
I. S. Zagon
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Pancreatic Cancer ◽  
Growth Media ◽  
Human Pancreatic Cancer Cell ◽  
Cell Extracts

The gastrointestinal peptides gastrin and cholecystokinin (CCK) stimulate growth of human pancreatic cancer through a CCK-B/gastrin- like receptor. In the present study we evaluated whether growth of human pancreatic cancer is endogenously regulated by gastrin. Immunohistomical examination of BxPC-3 cells and tumor xenografts revealed specifc gastrin immunoreactivity. Gastrin was detected by radioimmunoassay in pancreatic cancer cell extracts and in pancreatic cancer cell extracts and in the growth media. With use of reverse-transcriptase polymerase chain reaction gastrin gene expression was detected in both cultured BxPC-3 cancer cells and transplanted tumors, as well as seven addition human pancreatic cancer cell lines. Growth of BxPC-3 human pancreatic cancer cell in serum-free medium was inhibited by the addition of the CCK-B/gastrin receptor antagonist L-365,260, and gastrin treatment reversed the inhibitory effect of the antagonist. A selective gastrin antibody (Ab repressed growth of BxPC-3 cells. Gastrin immunoreactivity was detected in fresh human pancreatic cancer specimens but not in normal human pancreatic tissue. These data provide the first evidence that growth of a human pancreatic cancer is tonically stimulated by the autocrine production of gastrin. Evidence for the ubiquity of this system was provided by the detection of gastrin gene expression in multiple human pancreatic cancer cell lines and detection of gastrin in cell lines and fresh pancreatic tumors.

scholarly journals Verteporfin-based photodynamic therapy overcomes gemcitabine insensitivity in a panel of pancreatic cancer cell lines

2011 ◽  
Vol 43 (7) ◽  
pp. 565-574 ◽  
Author(s):  
Jonathan P. Celli ◽  
Nicolas Solban ◽  
Alvin Liang ◽  
Stephen P. Pereira ◽  
Tayyaba Hasan
Keyword(s):  
Pancreatic Cancer ◽  
Photodynamic Therapy ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines

scholarly journals OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling

Oncotarget ◽  
2017 ◽  
Vol 8 (17) ◽  
pp. 29233-29246 ◽  
Author(s):  
Wan-Chi Tsai ◽  
Li-Yuan Bai ◽  
Yi-Jin Chen ◽  
Po-Chen Chu ◽  
Ya-Wen Hsu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Lines ◽  
Stat3 Signaling
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