Tu1331 Are We Under-Recognizing Skewed Thiopurine Metabolism in IBD Patients? Routine Thiopurine Metabolite Measurement Yields Clinical Benefit at 12 Months: A Retrospective Observational Study

2015 ◽  
Vol 148 (4) ◽  
pp. S-861
Author(s):  
Soong-Yuan J. Ooi ◽  
Michael Gounder ◽  
Rachel Grafton ◽  
Peta Leach ◽  
Peter A. Bampton ◽  
...  
Keyword(s):  
Observational Study ◽  
Clinical Benefit ◽  
Retrospective Observational Study ◽  
Metabolite Measurement

Hemmkörperentwicklung bei Hämophilie-Patienten nach Präparate wechsel

2012 ◽  
Vol 32 (S 01) ◽  
pp. S39-S42 ◽  
Author(s):  
S. Kocher ◽  
G. Asmelash ◽  
V. Makki ◽  
S. Müller ◽  
S. Krekeler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Frequent Change ◽  
Patient Age ◽  
Treatment Regimens ◽  
Patient Âgé ◽  
The Relationship ◽  
Observation Period

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.

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