Tu1621 Farnesoid X Receptor (FXR) Regulates Intestinal G Protein-Coupled Bile Acid Receptor 1 and Glucagon-Like Peptide 1 Secretion

2016 ◽  
Vol 150 (4) ◽  
pp. S1151
Author(s):  
Preeti Pathak ◽  
Shannon Boehme ◽  
John Y. Chiang
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Farnesoid X Receptor ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
G Protein Coupled

TGR5 in inflammation and cardiovascular disease

2014 ◽  
Vol 42 (2) ◽  
pp. 244-249 ◽  
Author(s):  
Thijs W.H. Pols
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Animal Studies ◽  
Nuclear Factor Κb ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
Glucagon Like Peptide 1 ◽  
Membrane Type ◽  
G Protein Coupled

TGR5 (Takeda G-protein-coupled receptor 5) [also known as GPBAR1 (G-protein-coupled bile acid receptor 1), M-BAR (membrane-type receptor for bile acids) or GPR131 (G-protein-coupled receptor 131)] is a G-protein-coupled receptor that was discovered as a bile acid receptor. TGR5 has specific roles in several tissues, among which are the regulation of energy expenditure, GLP-1 (glucagon-like peptide 1) secretion and gall bladder filling. An accumulating body of evidence now demonstrates that TGR5 also acts in a number of processes important in inflammation. Most striking in this context are several observations that TGR5 signalling curbs the inflammatory response of macrophages via interfering with NF-κB (nuclear factor κB) activity. In line with this, recent animal studies also suggest that TGR5 could be exploited as a potential target for intervention in a number of inflammation-driven diseases, including atherosclerosis. In the present paper, I review our current understanding of TGR5 with a strong focus on its potential as target for intervention in inflammation-driven diseases.

Exploitation of Cholane Scaffold for the Discovery of Potent and Selective Farnesoid X Receptor (FXR) and G-Protein Coupled Bile Acid Receptor 1 (GP-BAR1) Ligands

2014 ◽  
Vol 57 (20) ◽  
pp. 8477-8495 ◽  
Author(s):  
Carmen Festa ◽  
Barbara Renga ◽  
Claudio D’Amore ◽  
Valentina Sepe ◽  
Claudia Finamore ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Farnesoid X Receptor ◽  
Acid Receptor ◽  
Bile Acid Receptor ◽  
G Protein Coupled

scholarly journals The G protein coupled bile acid receptor TGR5 (Gpbar1) modulates endothelin-1 signaling in liver

2020 ◽  
Author(s):  
C Klindt ◽  
M Reich ◽  
B Hellweg ◽  
J Stindt ◽  
J Rahnenführer ◽  
...  
Keyword(s):  
Bile Acid ◽  
G Protein ◽  
Acid Receptor ◽  
Endothelin 1 ◽  
Bile Acid Receptor ◽  
G Protein Coupled
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