Mo1821 - Poor Sleep Quality is a Risk Factor for Hospitalization and Surgery in Crohn's Disease

Abstract Background and Aims Poor sleep quality in Crohn’s disease (CD) is associated with histologic activity and clinical relapse. We sought to characterize sleep dysfunction and determine the effect of poor sleep quality on risk for hospitalization and surgery. Methods Clinical data were collected for CD subjects including the Pittsburgh Sleep Quality Index (PSQI) and Harvey-Bradshaw index (HBI). The PSQI score and a brief medical history were obtained for control subjects. The PSQI and HBI correlation was tested at an initial clinic visit and at follow-up. Crohn’s disease subjects with and without poor sleep were compared for risk of hospitalization or surgery by Kaplan–Meier and Cox proportional hazards. Results Ninety-two CD and 82 control subjects were included. Crohn’s disease and control subjects shared similar baseline characteristics and PSQI (8.3 vs 7.8, P = 0.31), and 77% of the CD population had PSQI >5. Crohn’s disease subjects with PSQI >5 more often had inflammatory phenotypes and reported increased benzodiazepine and psychiatric medication use. Crohn’s disease subjects with PSQI >5 also reported more night awakenings due to pain and bathroom use. The PSQI correlated with HBI (r = 0.256, P = 0.014), and ΔPSQI on follow-up correlated with ΔHBI (r = 0.47, P = 0.002). Cox proportional hazards model for hospitalization or surgery showed that PSQI >8 was predictive of surgery or hospitalization (hazards ratio 5.37; 95% confidence interval, 1.39–27.54). Conclusion There is a high burden of poor sleep quality in CD, which is associated with risk for adverse outcomes. Sleep quality may identify CD patients at risk for complications and have prognostic value in CD.

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P192 Heartburn in Crohn's disease is associated with increased disease activity, poor sleep quality and prior ileocecectomy

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjx002.317 ◽

2017 ◽

Vol 11 (suppl_1) ◽

pp. S173-S174 ◽

Cited By ~ 1

Author(s):

M.A. Sofia ◽

A.M. Lipowska ◽

E.Y. Perez ◽

N. Zmeter ◽

R.T. Kavitt ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Sleep Quality ◽

Disease Activity ◽

Poor Sleep ◽

Poor Sleep Quality

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THE MODERATING EFFECT OF RAISING ONE’S GRANDCHILDREN ON THE RELATION BETWEEN SLEEP AND DEPRESSION

Innovation in Aging ◽

10.1093/geroni/igz038.2505 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S678-S678

Author(s):

Melanie Stearns ◽

Danielle K Nadorff

Keyword(s):

Older Adults ◽

Risk Factor ◽

Depressive Symptoms ◽

Sleep Quality ◽

Sleep Problems ◽

Depression Scale ◽

Poor Sleep ◽

Older Individuals ◽

Poor Sleep Quality ◽

Custodial Grandparents

Abstract Recent evidence has shown that poor quality sleep is associated with depression, particularly among older individuals (Bao et al., 2017; Nadorff, Fiske, Sperry, & Petts, 2012). Moreover, given the high prevalence of depressive symptoms among older adults, it is important to identify possible risk factors of poor sleep quality. One possible risk factor is being a custodial grandparent (raising one’s grandchildren), as increased caregiving responsivities are associated with increased depressive symptoms (Brand-Winterstein, Edelstein, & Bachner, 2018). Based upon these previous findings, the current study examines the effect of custodial status on the relation between sleep quality and depressive symptoms. The sample (N = 466) was a subset of individuals recruited in the second wave of the MIDUS biomarkers project completed in 2009 who answered the sleep, caregiving, and depressive symptoms variables of interest. Measures included the Center for Epidemiological Studies Depression Scale (CESD), the Pittsburgh Sleep Quality Index (PSQI), and a question regarding custodial grandparent status. The current study aimed to examine whether poor sleep quality might serve as a risk factor for experiencing depressive symptoms and how custodial grandparents might differ from other older adults. Moderation analyses were conducted using SPSS’ Process macro on the sample. The interaction between global sleep quality and custodial grandparent status was significant in predicting depressive symptoms, t (1, 465) = 3.90, p = .04, such that custodial grandparents reported a stronger positive correlation between greater global sleep problems and depressive symptoms than non-custodial grandparents. Implications, future directions, and limitations are discussed.

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Poor Sleep Quality As a Risk Factor for Poorly-Controlled Asthma in Children

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2014.12.1509 ◽

2015 ◽

Vol 135 (2) ◽

pp. AB176

Author(s):

Youn Ho Shin ◽

Sun Jung Jang ◽

Ji Hyeon Baek ◽

Hye Mi Jee ◽

Kyu Young Chae ◽

...

Keyword(s):

Risk Factor ◽

Sleep Quality ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Asthma In Children

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High Cortisol Levels As A Risk Factor For Poor Sleep Quality In Informal Caregiver Breast Cancer Patients At Sanglah Hospital Denpasar

International Journal of Medical Reviews and Case Reports ◽

10.5455/ijmrcr.high-cortisol-level-breast-cancer-607 ◽

2021 ◽

pp. 1

Author(s):

Rindha Sihanto ◽

Desak Utami ◽

Anak Laksmidewi ◽

I Adnyana ◽

I Widyadharma ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factor ◽

Sleep Quality ◽

Cancer Patients ◽

Informal Caregiver ◽

Poor Sleep ◽

Breast Cancer Patients ◽

Poor Sleep Quality ◽

Cortisol Levels

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Poor sleep quality as a risk factor for lapse following a cannabis quit attempt

Journal of Substance Abuse Treatment ◽

10.1016/j.jsat.2012.08.224 ◽

2013 ◽

Vol 44 (4) ◽

pp. 438-443 ◽

Cited By ~ 30

Author(s):

Kimberly A. Babson ◽

Matthew Tyler Boden ◽

Alex H. Harris ◽

Timothy R. Stickle ◽

Marcel O. Bonn-Miller

Keyword(s):

Risk Factor ◽

Sleep Quality ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Quit Attempt

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Family aggregation of sleep characteristics: Results of the Heinz Nixdorf Recall and the Multi-Generation Study

PLoS ONE ◽

10.1371/journal.pone.0252828 ◽

2021 ◽

Vol 16 (6) ◽

pp. e0252828

Author(s):

Bernd Kowall ◽

Anna-Therese Lehnich ◽

Sara Schramm ◽

Börge Schmidt ◽

Raimund Erbel ◽

...

Keyword(s):

Risk Factor ◽

Sleep Quality ◽

Sleep Disorders ◽

Adult Children ◽

Sleep Problems ◽

Adult Child ◽

Poor Sleep ◽

Poor Sleep Quality ◽

Ruhr Area ◽

Falling Asleep

Introduction Poor sleep is a risk factor for adverse health events. For health prevention, it may be helpful to know whether poor sleep or sleep disorders in individuals are associated with sleep problems in their partners or children. Methods In the MultiGeneration Study (MGS, conducted from 2013 to 2016), 1237 partners (aged 27 to 90 years) and 1660 adult children (aged 18 to 66 years) of index persons were recruited. Index persons are participants of the Heinz Nixdorf Recall Study, a population-based cohort study in the Ruhr area (study start 1999–2001, 4841 participants aged 45–75 years). We used two analysis populations: one with 1181 index persons whose partners were in MGS, and one with 1083 index persons with at least one adult child in MGS. Sleep characteristics were assessed using questionnaires (including the Pittsburgh Sleep Quality Index). The exposure was the presence of a sleep characteristic of the index subject. Results Children showed the investigated sleep characteristics more often if these were also present in their parent (e.g., RR (relative risk) = 1.28 (95% CI: 1.06–1.55) for poor sleep quality). In partners, strong associations were observed for rising times and napping, but only weak associations for snoring, poor sleep quality and sleep disorders. Snoring of the bed partner is a risk factor for poor sleep (e.g., RR = 1.67 (0.91–3.07) for difficulties falling asleep). Conclusion Aggregation is observed for many sleep characteristics in people living in partnerships as well as in parents and their adult children.

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