Poor Sleep Quality in Crohn's Disease is Associated with Antibiotic Use and Gerd Symptom Severity

2017 ◽  
Vol 152 (5) ◽  
pp. S799 ◽  
Author(s):  
Mark A. Sofia ◽  
Anna M. Lipowska ◽  
Edgar Y. Perez ◽  
Nada Zmeter ◽  
Robert Kavitt ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Sleep Quality ◽  
Symptom Severity ◽  
Gerd Symptom ◽  
Antibiotic Use ◽  
Poor Sleep ◽  
Poor Sleep Quality

Mo1821 - Poor Sleep Quality is a Risk Factor for Hospitalization and Surgery in Crohn's Disease

2018 ◽  
Vol 154 (6) ◽  
pp. S-815
Author(s):  
M. Anthony Sofia ◽  
Anna M. Lipowska ◽  
Edgar Y. Perez ◽  
Nada Zmeter ◽  
Robert T. Kavitt ◽  
...  
Keyword(s):  
Risk Factor ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Sleep Quality ◽  
Poor Sleep ◽  
Poor Sleep Quality

scholarly journals Poor Sleep Quality in Crohn’s Disease Is Associated With Disease Activity and Risk for Hospitalization or Surgery

2019 ◽  
Author(s):  
M Anthony Sofia ◽  
Anna M Lipowska ◽  
Nada Zmeter ◽  
Edgar Perez ◽  
Robert Kavitt ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Sleep Quality ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Poor Sleep ◽  
Clinical Relapse ◽  
Poor Sleep Quality ◽  
Control Subjects

Abstract Background and Aims Poor sleep quality in Crohn’s disease (CD) is associated with histologic activity and clinical relapse. We sought to characterize sleep dysfunction and determine the effect of poor sleep quality on risk for hospitalization and surgery. Methods Clinical data were collected for CD subjects including the Pittsburgh Sleep Quality Index (PSQI) and Harvey-Bradshaw index (HBI). The PSQI score and a brief medical history were obtained for control subjects. The PSQI and HBI correlation was tested at an initial clinic visit and at follow-up. Crohn’s disease subjects with and without poor sleep were compared for risk of hospitalization or surgery by Kaplan–Meier and Cox proportional hazards. Results Ninety-two CD and 82 control subjects were included. Crohn’s disease and control subjects shared similar baseline characteristics and PSQI (8.3 vs 7.8, P = 0.31), and 77% of the CD population had PSQI >5. Crohn’s disease subjects with PSQI >5 more often had inflammatory phenotypes and reported increased benzodiazepine and psychiatric medication use. Crohn’s disease subjects with PSQI >5 also reported more night awakenings due to pain and bathroom use. The PSQI correlated with HBI (r = 0.256, P = 0.014), and ΔPSQI on follow-up correlated with ΔHBI (r = 0.47, P = 0.002). Cox proportional hazards model for hospitalization or surgery showed that PSQI >8 was predictive of surgery or hospitalization (hazards ratio 5.37; 95% confidence interval, 1.39–27.54). Conclusion There is a high burden of poor sleep quality in CD, which is associated with risk for adverse outcomes. Sleep quality may identify CD patients at risk for complications and have prognostic value in CD.

scholarly journals P192 Heartburn in Crohn's disease is associated with increased disease activity, poor sleep quality and prior ileocecectomy

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S173-S174 ◽  
Author(s):  
M.A. Sofia ◽  
A.M. Lipowska ◽  
E.Y. Perez ◽  
N. Zmeter ◽  
R.T. Kavitt ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Sleep Quality ◽  
Disease Activity ◽  
Poor Sleep ◽  
Poor Sleep Quality

scholarly journals P207 Poor sleep quality is a risk factor for hospitalisation and surgery in Crohn’s disease

2018 ◽  
Vol 12 (supplement_1) ◽  
pp. S204-S204 ◽  
Author(s):  
M A Sofia ◽  
A M Lipowska ◽  
E Y Perez ◽  
N Zmeter ◽  
R T Kavitt ◽  
...  
Keyword(s):  
Risk Factor ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Sleep Quality ◽  
Poor Sleep ◽  
Poor Sleep Quality

Association Between Sleep Quality and Recovery Following Sport-Related Concussion in Pediatrics

2019 ◽  
Vol 34 (11) ◽  
pp. 639-645 ◽  
Author(s):  
Jane S. Chung ◽  
Aaron J. Zynda ◽  
Nyaz Didehbani ◽  
Cason Hicks ◽  
Linda S. Hynan ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Symptom Severity ◽  
Early Recognition ◽  
Clinic Visit ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
North Texas ◽  
The North ◽  
Prolonged Recovery

Our objective was to determine the association between sleep quality, symptom severity, and recovery following sport-related concussion in pediatric athletes. A review of data from the North Texas Concussion Network Prospective Registry (ConTex) was performed. Participants were diagnosed with a sport-related concussion and were ≤18 years old. Participants were categorized based on their initial clinic visit Pittsburgh Sleep Quality Index composite score (0-21) into good sleep quality (GS≤5) and poor sleep quality (PS>5) groups. The PS group reported higher median total symptom scores at 3-month follow-up (3.0 vs 0.0, P < .01) and took more than a median of 2 weeks longer to recover compared to the GS group (35.0 days vs 20.0 days, P < .01). Poor sleep quality was strongly associated with greater symptom severity and longer time to recovery following sport-related concussion. Early recognition of concussed athletes with poor sleep quality at initial clinic visit may help predict prolonged recovery.

scholarly journals The effects of emotional lability, mind wandering and sleep quality on ADHD symptom severity in adults with ADHD

2019 ◽  
Vol 55 ◽  
pp. 45-51 ◽  
Author(s):  
Bartosz Helfer ◽  
Ruth E. Cooper ◽  
Natali Bozhilova ◽  
Stefanos Maltezos ◽  
Jonna Kuntsi ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Adhd Symptom ◽  
Symptom Severity ◽  
Adult Adhd ◽  
Mind Wandering ◽  
Future Research ◽  
Poor Sleep ◽  
Emotional Lability ◽  
Neural Basis ◽  
Poor Sleep Quality

AbstractMind wandering, emotional lability and sleep quality are currently mostly independently investigated but are all interlinked and play a major role is adult attention-deficit/ hyperactivity disorder (ADHD). Emotional lability is a core feature of the disorder, excessive mind wandering has recently been linked to symptoms and impairments of ADHD and poor sleep quality is experienced by a clear majority of adults with ADHD. All three phenomena lead to functional impairment in ADHD, however their relationship to each other and to ADHD symptom severity is not well understood. Here we used serial multiple mediation models to examine the influence of mind wandering, sleep quality and emotional lability on ADHD symptom severity. 81 adults diagnosed with ADHD participated in this study. We found that mind wandering and emotional lability predicted ADHD symptom severity and that mind wandering, emotional lability and sleep quality were all linked and significantly contributed to the symptomatology of adult ADHD. Mind wandering was found to lead to emotional lability which in turn lead to ADHD symptom severity; and poor sleep quality was found to exacerbate mind wandering leading to ADHD symptoms. Future research should employ objective on-task measures of mind wandering, sleepiness and emotional lability to investigate the neural basis of these impairing deficits in ADHD.

Association of severity of depressive symptoms with sleep quality, social support and stress among Pakistani medical and dental students: A cross-sectional study

2019 ◽  
Vol 2 (2) ◽  
pp. 211-220
Author(s):  
Ahmed Waqas ◽  
Aqsa Iftikhar ◽  
Zahra Malik ◽  
Kapil Kiran Aedma ◽  
Hafsa Meraj ◽  
...  
Keyword(s):  
Social Support ◽  
Depressive Symptoms ◽  
Medical Students ◽  
Sleep Quality ◽  
Severe Depression ◽  
Dental Students ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Cross Sectional ◽  
Medical And Dental Students

AbstractObjectivesThis study has been designed to elucidate the prevalence of stress, depression and poor sleep among medical students in a Pakistani medical school. There is a paucity of data on social support among medical students in Pakistan; an important predictor of depressive symptoms. Therefore, this study was also aimed to demonstrate the direct and indirect impact of social support in alleviating depressive symptoms in the study sample.MethodsThis observational cross-sectional study was conducted in Lahore, Pakistan, where a total of 400 students at a medical school were approached between 1st January to 31st March 2018 to participate in the study. The study sample comprised of medical and dental students enrolled at a privately financed Pakistani medical and dental school. The participants responded to a self-administered survey comprising of five parts: a) demographics, b) Pittsburgh Sleep Quality Index (PSQI), c) Patient Health Questionnaire-9 (PHQ-9), d) Multidimensional Scale of Perceived Social Support (MSPSS) and e) Perceived Stress Scale-4 (PSS-4). All data were analysed using SPSS v. 20. Linear regression analysis was used to reveal the predictors of depression.ResultsIn total, 353 medical students participated, yielding a response rate of 88.25%. Overall, poor sleep quality was experienced by 205 (58.1%) students. Mild to severe depression was reported by 83% of the respondents: mild depression by 104 (29.5%), moderate depression by 104 (29.5%), moderately severe depression by 54 (15.3%) and severe depression by 31 (8.8%) respondents. Subjective sleep quality, sleep latency, daytime dysfunction and stress levels were significantly associated with depression symptoms. Social support was not significantly associated with depressive symptoms in the regression model (Beta = -0.08, P < 0.09); however, it acted as a significant mediator, reducing the strength of the relationship between depressive symptoms and sleep quality and stress.ConclusionsAccording to our study, a large proportion of healthcare (medical and dental) students were found to be suffering from mild to moderate depression and experienced poor sleep quality. It is concluded that social support is an important variable in predicting depressive symptomatology by ameliorating the effects of poor sleep quality and high stress levels.

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