Sa1081 UNIQUE MECHANISMS OF REGULATION OF L-TYPE AMINO-ACID TRANSPORTER 1 (LAT1) BY INDUCIBLE NITRIC OXIDE IN NORMAL SMALL INTESTINAL AND COLON EPITHELIAL CELLS AND COLON CANCER CELLS

2020 ◽  
Vol 158 (6) ◽  
pp. S-270
Author(s):  
Shanmuga Sundaram ◽  
Motiur Rahman ◽  
Soudamani Singh ◽  
Travis Salisbury ◽  
Uma Sundaram
Keyword(s):  
Nitric Oxide ◽  
Colon Cancer ◽  
Amino Acid ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Amino Acid Transporter ◽  
Colon Cancer Cells ◽  
Small Intestinal ◽  
Acid Transporter ◽  
Inducible Nitric Oxide

scholarly journals Hyperoxia Inhibits Nitric Oxide Treatment Effects in Alveolar Epithelial Cells via Effects on L-Type Amino Acid Transporter-1

2014 ◽  
Vol 21 (13) ◽  
pp. 1823-1836 ◽  
Author(s):  
Mulugu V. Brahmajothi ◽  
Brian T. Tinch ◽  
Michael F. Wempe ◽  
Hitoshi Endou ◽  
Richard L. Auten
Keyword(s):  
Nitric Oxide ◽  
Amino Acid ◽  
Epithelial Cells ◽  
Treatment Effects ◽  
Amino Acid Transporter ◽  
Alveolar Epithelial Cells ◽  
Alveolar Epithelial ◽  
Acid Transporter

scholarly journals Comparative phosphoproteomics between non-competitive and competitive inhibitions of L-type amino acid transporter 1 in cancer cells.

2019 ◽  
Vol 92 (0) ◽  
pp. 1-P-106
Author(s):  
Pornparn Kongpracha ◽  
Pattama Wiriyasermkul ◽  
Yoko Tanaka ◽  
Suguru Okuda ◽  
Ryuichi Ohgaki ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cancer Cells ◽  
Amino Acid Transporter ◽  
Acid Transporter

scholarly journals Anti‐tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS ‐mutated human colorectal cancer cells

2019 ◽  
Vol 9 (1) ◽  
pp. 302-312 ◽  
Author(s):  
Yuta Hara ◽  
Yushi Minami ◽  
Soshi Yoshimoto ◽  
Natsumi Hayashi ◽  
Akitaka Yamasaki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Amino Acid ◽  
Cancer Cells ◽  
Amino Acid Transporter ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Acid Transporter ◽  
Human Colorectal Cancer Cells

scholarly journals Uptake of nitric oxide synthase inhibitors by macrophage RAW 264.7 cells

1994 ◽  
Vol 301 (2) ◽  
pp. 313-316 ◽  
Author(s):  
K Schmidt ◽  
P Klatt ◽  
B Mayer
Keyword(s):  
Nitric Oxide ◽  
Amino Acid ◽  
Nitric Oxide Synthase ◽  
Amino Acid Transporter ◽  
Raw 264.7 Cells ◽  
Cationic Amino Acid ◽  
Nitric Oxide Synthase Inhibitors ◽  
System L ◽  
Acid Transporter ◽  
Oxide Synthase

Uptake of the nitric oxide synthase inhibitors NG-methyl-L-arginine (L-NMA) and NG-nitro-L-arginine (L-NNA) by macrophages is mediated by two different mechanisms. Activation of the cells with cytokines resulted in an up-regulation of L-NMA uptake but did not affect L-NNA transport. Characterization of the transport sites revealed that uptake of L-NMA is mediated by a cationic amino acid transporter (system y+) whereas a neutral amino acid transporter (system L) accounts for the uptake of L-NNA.

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