CEA is useful to determine the need for a preoperative CT scan in patients with colorectal cancer

1998 ◽  
Vol 114 ◽  
pp. A1400
Author(s):  
S Kelly ◽  
MA Malangoni
Keyword(s):  
Colorectal Cancer ◽  
Ct Scan ◽  
Preoperative Ct

scholarly journals Correlation between preoperative CT scan and lung metastases according to surgical approach in patients with colorectal cancer

2021 ◽  
Author(s):  
Jorge Hernández ◽  
Laureano Molins ◽  
Juan J. Fibla ◽  
Ángela Guirao ◽  
Juan J. Rivas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ct Scan ◽  
Surgical Approach ◽  
Lung Metastases ◽  
Preoperative Ct

Value of cardiophrenic angle lymph nodes for the diagnosis of colorectal peritoneal carcinomatosis.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 372-372
Author(s):  
Caroline Caramella ◽  
David Malka ◽  
Edwige Pottier ◽  
Diane Goéré ◽  
Valerie Boige ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Ct Scan ◽  
Peritoneal Carcinomatosis ◽  
Odds Ratio ◽  
Multivariate Analyses ◽  
Ct Scans ◽  
Lymph Node Status ◽  
Preoperative Ct ◽  
Potential Sign

372 Background: The radiological diagnosis of peritoneal carcinomatosis (PC) is challenging. Metastases in the cardiophrenic angle lymph nodes (CPALN) have been anecdotally reported in patients with abdominopelvic malignancies. We aimed to assess whether CPALN detected by computed tomography (CT)-scan are associated with PC in patients with colorectal cancer (CRC). Methods: Between 2007 and 2010, 550 patients with CRC, including 165 (30%) with PC, underwent surgery with complete exploration of the peritoneal cavity in our center. We retrospectively reviewed preoperative CT-scans for the presence of CPALN, and assessed the association of CPALN with surgically confirmed PC by univariate and multivariate analyses. Results: CPALN were present in 123 (75%) of the 165 patients with PC, but absent in 263 (68%) of the 385 patients without PC (sensitivity (Se), 0.72; specificity (Sp), 0.68; positive predictive value (PPV), 0.49; negative PV (NPV), 0.85; odds ratio [OR], 3.3; p<0.001). The presence of CPALN was not correlated with the extent of PC, the primary tumor and lymph node status , or the presence, number, size and location of liver metastases. Among the 165 patients with PC, 99 (60%) had visible signs of PC (other than CPALN) on CT-scan; among the remaining 66 patients, CPALN were the only potential sign of CP in 41 (62%), leading to Se, Sp, PPV, and NPV in patients with no signs of CP (other than CPALN) on CT of 0.62, 0.68, 0.24, and 0.92, respectively. Conclusions: The detection of CPALN on CT may be of valuable help for the diagnosis of PC in patients with CRC.

scholarly journals ctDNA Clearance and Radiographic Resolution of Disease in Response to Dual Checkpoint Inhibition in Metastatic Microsatellite Stable Colorectal Cancer with a High Tumor Mutation Burden

2021 ◽  
pp. 849-853
Author(s):  
Charles J. Schneider ◽  
Michael Krainock ◽  
Allyson Koyen Malashevich ◽  
Meenakshi Malhotra ◽  
Perry Olshan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Ct Scan ◽  
Circulating Tumor Dna ◽  
Therapeutic Benefit ◽  
Tumor Mutation Burden ◽  
Early Treatment Response ◽  
Mutation Burden ◽  
Disease Present

Immunotherapy (IO) has increasingly been demonstrated to provide therapeutic benefit to patients with metastatic colorectal cancer (mCRC). However, only a subset of mCRC tumors respond to IO. Monitoring response with tumor biomarkers like carcinoembryonic antigen (CEA) has been challenging in patients with microsatellite stable (MSS) mCRC due to low expression of CEA (CEA/lo). Noninvasive blood-based biomarkers such as circulating tumor DNA (ctDNA) can inform early treatment response and augment radiographic monitoring. We describe a case study of a patient with chemotherapy-refractory CEA/lo MSS mCRC, with metastatic disease present in a cardiophrenic lymph node. The patient was given 2 cycles of combination IO (ipilimumab/nivolumab). Response was monitored by ctDNA using a multiplex PCR next-generation sequencing assay, CEA, and CT scan. After IO administration, ctDNA levels rapidly declined, becoming undetectable. This was concurrent with radiographic resolution of the lymph node metastasis. Serial monitoring of CEA during this same period was uninformative, with no significant changes observed. Significant decline in ctDNA identified metastatic response to IO in a patient with CEA/lo, MSS mCRC and was concurrently validated by CT scan. This case study provides evidence that ctDNA can be used as a prospective surrogate for radiographic tumor response.

Incidental Colorectal Findings of PET/CT Scan in Patients with Malignancies Other Than Colorectal Cancer

2008 ◽  
Vol 67 (5) ◽  
pp. AB313
Author(s):  
Kiyoko Yoshino ◽  
Naomi Kakushima ◽  
Kouichi Nonaka ◽  
Akira Aso ◽  
Masamitsu Nakao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ct Scan ◽  
Pet Ct ◽  
Pet Ct Scan

Management of the Orbital Floor in Silent Sinus Syndrome

2003 ◽  
Vol 17 (2) ◽  
pp. 97-100 ◽  
Author(s):  
Robert D. Thomas ◽  
Scott M. Graham ◽  
Keith D. Carter ◽  
Jeffrey A. Nerad
Keyword(s):  
Ct Scan ◽  
Maxillary Sinus ◽  
Current Trend ◽  
Ct Scanning ◽  
Volumetric Analysis ◽  
Orbital Floor ◽  
Second Stage ◽  
Silent Sinus Syndrome ◽  
Orbital Floor Reconstruction ◽  
Preoperative Ct

Background Enophthalmos in a patient with an opacified hypoplastic maxillary sinus, without sinus symptomatology, describes the silent sinus syndrome. A current trend is to perform endoscopic maxillary antrostomy and orbital floor reconstruction as a single-staged operation. A two-staged approach is performed at our institution to avoid placement of an orbital floor implant in the midst of potential infection and allow for the possibility that enophthalmos and global ptosis may resolve with endoscopic antrostomy alone, obviating the need for orbital floor reconstruction. Methods A retrospective review identified four patients with silent sinus syndrome evaluated between June 1999 and August 2001. Patients presented to our ophthalmology department with ocular asymmetry, and computerized tomography (CT) scanning confirmed the diagnosis in each case. Results There were three men and one woman, with ages ranging from 27 to 40 years. All patients underwent endoscopic maxillary antrostomy. Preoperative enophthalmos determined by Hertel's measurements ranged from 3 to 4 mm. After endoscopic maxillary antrostomy, the range of reduction in enophthalmos was 1–2 mm. Case 2 had a preoperative CT scan and a CT scan 9 months after left endoscopic maxillary antrostomy. Volumetric analysis of the left maxillary sinus revealed a preoperative volume of 16.85 ± 0.06 cm3 and a postoperative volume of 19.56 ± 0.07 cm3. This represented a 16% increase in maxillary sinus volume postoperatively. Orbital floor augmentation was avoided in two patients because of satisfactory improvement in enophthalmos. In the other two patients, orbital reconstruction was performed as a second-stage procedure. There were no complications. Conclusion Orbital floor augmentation can be offered as a second-stage procedure for patients with silent sinus syndrome. Some patients’ enophthalmos may improve with endoscopic antrostomy alone.

scholarly journals EP-1169: Preoperative CT scan in tumor bed delineation after breast conserving surgery and oncoplasty

2017 ◽  
Vol 123 ◽  
pp. S635
Author(s):  
T. Saxena ◽  
V. Goel ◽  
G. Kadyaprath ◽  
D. Arora ◽  
A.K. Verma ◽  
...  
Keyword(s):  
Ct Scan ◽  
Breast Conserving Surgery ◽  
Tumor Bed ◽  
Preoperative Ct

scholarly journals STUDY OF THE POSSIBILITIES OF PREOPERATIVE CHEMOTHERAPY IN MULTIPLE METASTASIS OF COLORECTAL CANCER IN THE LIVER

2020 ◽  
Vol 1 (8(77)) ◽  
pp. 8-11
Author(s):  
Kh.D. Islamov ◽  
Sh.Kh. Niyozova
Keyword(s):  
Colorectal Cancer ◽  
Side Effects ◽  
Liver Metastases ◽  
Preoperative Chemotherapy ◽  
High Frequency ◽  
Partial Regression ◽  
Multiple Metastasis ◽  
Preoperative Ct ◽  
Multiple Liver Metastases ◽  
Surgical Operations

Preoperative chemotherapy (CT) in 35 patients with colorectal cancer (CRC) with liver metastases demonstrated a high frequency of objective effects - in 22 (62.9%) patients, stabilization was noted in 10 (28.6%) cases. With bilobar liver metastases and the use of oxaliplatin-containing regimens, partial regression was 62.9%. Side effects in most cases were clinically insignificant, no deaths were observed. The results obtained demonstrate the possibility of performing extended surgical operations in the majority of CRC patients with multiple liver metastases after preoperative CT.

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