scholarly journals Effects of NKY-722, a novel calcium antagonist, on the changes of cardiac energy metabolism — an in vivo 31P-MRS study

1992 ◽  
Vol 58 ◽  
pp. 274
Author(s):  
Yuta Kobayashi ◽  
Youko Tanabe ◽  
Kazumasa Shinozuka ◽  
Shuji Takaori ◽  
Keisuke Hattori
Keyword(s):  
Calcium Antagonist ◽  
Energy Metabolism ◽  
31P Mrs ◽  
Cardiac Energy Metabolism ◽  
Cardiac Energy

Impairment of Cardiac Energy Metabolism In Vivo Causes Hemodynamic Abnormality and Increases Cardiac Expression of Preproendothelin-1 mRNA

2000 ◽  
Vol 36 ◽  
pp. S128-S131
Author(s):  
Nobuyuki Murakoshi ◽  
Takashi Miyauchi ◽  
Yoshihiko Kakinuma ◽  
Koichi Yuki ◽  
Katsutoshi Goto ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cardiac Energy Metabolism ◽  
Cardiac Energy

Impairment of Cardiac Energy Metabolism In Vivo Causes Hemodynamic Abnormality and Increases Cardiac Expression of Preproendothelin-1 mRNA

2000 ◽  
Vol 36 (Supplement 1) ◽  
pp. S128-S131 ◽  
Author(s):  
Nobuyuki Murakoshi ◽  
Takashi Miyauchi ◽  
Yoshihiko Kakinuma ◽  
Koichi Yuki ◽  
Katsutoshi Goto ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cardiac Energy Metabolism ◽  
Cardiac Energy

scholarly journals Impaired cardiac energy metabolism in embryos lacking adrenergic stimulation

2015 ◽  
Vol 308 (5) ◽  
pp. E402-E413 ◽  
Author(s):  
Candice N. Baker ◽  
Sarah A. Gidus ◽  
George F. Price ◽  
Jessica N. R. Peoples ◽  
Steven N. Ebert
Keyword(s):  
Energy Metabolism ◽  
Mouse Embryos ◽  
Adrenergic Stimulation ◽  
Energy Demands ◽  
Significant Difference ◽  
Cardiac Energy Metabolism ◽  
Consumption Rates ◽  
Cardiac Energy ◽  
Β Adrenergic Receptors

As development proceeds from the embryonic to fetal stages, cardiac energy demands increase substantially, and oxidative phosphorylation of ADP to ATP in mitochondria becomes vital. Relatively little, however, is known about the signaling mechanisms regulating the transition from anaerobic to aerobic metabolism that occurs during the embryonic period. The main objective of this study was to test the hypothesis that adrenergic hormones provide critical stimulation of energy metabolism during embryonic/fetal development. We examined ATP and ADP concentrations in mouse embryos lacking adrenergic hormones due to targeted disruption of the essential dopamine β-hydroxylase ( Dbh) gene. Embryonic ATP concentrations decreased dramatically, whereas ADP concentrations rose such that the ATP/ADP ratio in the adrenergic-deficient group was nearly 50-fold less than that found in littermate controls by embryonic day 11.5. We also found that cardiac extracellular acidification and oxygen consumption rates were significantly decreased, and mitochondria were significantly larger and more branched in adrenergic-deficient hearts. Notably, however, the mitochondria were intact with well-formed cristae, and there was no significant difference observed in mitochondrial membrane potential. Maternal administration of the adrenergic receptor agonists isoproterenol or l-phenylephrine significantly ameliorated the decreases in ATP observed in Dbh−/−embryos, suggesting that α- and β-adrenergic receptors were effective modulators of ATP concentrations in mouse embryos in vivo. These data demonstrate that adrenergic hormones stimulate cardiac energy metabolism during a critical period of embryonic development.

scholarly journals MicroRNA-146a as a Regulator of Cardiac Energy Metabolism

Circulation ◽  
2017 ◽  
Vol 136 (8) ◽  
pp. 762-764 ◽  
Author(s):  
Charlotte J. Demkes ◽  
Eva van Rooij
Keyword(s):  
Energy Metabolism ◽  
Cardiac Energy Metabolism ◽  
Cardiac Energy

scholarly journals Acetylation and succinylation contribute to maturational alterations in energy metabolism in the newborn heart

2016 ◽  
Vol 311 (2) ◽  
pp. H347-H363 ◽  
Author(s):  
Arata Fukushima ◽  
Osama Abo Alrob ◽  
Liyan Zhang ◽  
Cory S. Wagg ◽  
Tariq Altamimi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Energy Metabolism ◽  
Fatty Acid Oxidation ◽  
Glucose Oxidation ◽  
Acid Oxidation ◽  
Amino Acid Synthesis ◽  
Oxidation Rates ◽  
Cardiac Energy Metabolism ◽  
Cardiac Energy ◽  
The Impact

Dramatic maturational changes in cardiac energy metabolism occur in the newborn period, with a shift from glycolysis to fatty acid oxidation. Acetylation and succinylation of lysyl residues are novel posttranslational modifications involved in the control of cardiac energy metabolism. We investigated the impact of changes in protein acetylation/succinylation on the maturational changes in energy metabolism of 1-, 7-, and 21-day-old rabbit hearts. Cardiac fatty acid β-oxidation rates increased in 21-day vs. 1- and 7-day-old hearts, whereas glycolysis and glucose oxidation rates decreased in 21-day-old hearts. The fatty acid oxidation enzymes, long-chain acyl-CoA dehydrogenase (LCAD) and β-hydroxyacyl-CoA dehydrogenase (β-HAD), were hyperacetylated with maturation, positively correlated with their activities and fatty acid β-oxidation rates. This alteration was associated with increased expression of the mitochondrial acetyltransferase, general control of amino acid synthesis 5 like 1 (GCN5L1), since silencing GCN5L1 mRNA in H9c2 cells significantly reduced acetylation and activity of LCAD and β-HAD. An increase in mitochondrial ATP production rates with maturation was associated with the decreased acetylation of peroxisome proliferator-activated receptor-γ coactivator-1α, a transcriptional regulator for mitochondrial biogenesis. In addition, hypoxia-inducible factor-1α, hexokinase, and phosphoglycerate mutase expression declined postbirth, whereas acetylation of these glycolytic enzymes increased. Phosphorylation rather than acetylation of pyruvate dehydrogenase (PDH) increased in 21-day-old hearts, accounting for the low glucose oxidation postbirth. A maturational increase was also observed in succinylation of PDH and LCAD. Collectively, our data are the first suggesting that acetylation and succinylation of the key metabolic enzymes in newborn hearts play a crucial role in cardiac energy metabolism with maturation. Listen to this article’s corresponding podcast at http://ajpheart.podbean.com/e/acetylation-control-of-energy-metabolism-in-newborn-hearts/ .

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