scholarly journals Comparison of the effects of diltiazem and its charged derivative on L-type Ca2+ channels in guinea-pig ventricular myocyte.

1993 ◽  
Vol 61 ◽  
pp. 89
Author(s):  
Satomi Adachi-Akahane ◽  
Yukiko Amano ◽  
Taku Nagao
Keyword(s):  
Guinea Pig ◽  
Ventricular Myocyte ◽  
Charged Derivative ◽  
Ca2 Channels

NO-mediated MaxiKCa channel activation produces relaxation of guinea pig aorta independently of voltage-dependent L-type Ca2+ channels

2000 ◽  
Vol 34 (3) ◽  
pp. 159-165 ◽  
Author(s):  
Yoshio Tanaka ◽  
Tomomi Igarashi ◽  
Hiroki Kaneko ◽  
Fumiko Yamaki ◽  
Yumi Mochizuki ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Channel Activation ◽  
Voltage Dependent ◽  
Ca2 Channels

Effect of leukotriene C4 on electromechanical activity and Ca2+ uptake in taenia coli

1988 ◽  
Vol 255 (4) ◽  
pp. C433-C441 ◽  
Author(s):  
A. Zschauer ◽  
E. K. Matthews ◽  
B. P. Richardson
Keyword(s):  
Guinea Pig ◽  
Taenia Coli ◽  
Leukotriene C4 ◽  
Leukotriene Receptor Antagonist ◽  
Normal Medium ◽  
Membrane Conductivity ◽  
Sucrose Gap ◽  
Leukotriene Receptor ◽  
Measurable Change ◽  
Ca2 Channels

The actions of leukotriene C4 (LTC4) on electromechanical activity and 45Ca2+ uptake in guinea pig taenia coli were investigated. The contractile action of LTC4 was abolished by the removal of extracellular Ca2+. LTC4 concentrations eliciting a maximal contraction in normal medium produced no response in preparations depolarized with KCl. In single sucrose gap studies, LTC4 increased both the frequency of electrical spiking and tension. These effects were blocked by the dihydropyridine Ca2+-channel antagonist PY 108-068 and by the leukotriene receptor antagonist FPL 55712. In double sucrose gap experiments, LTC4 caused a small depolarization without measurable change in membrane conductivity; increased spontaneous electrical activity was again accompanied by an increase in tension. LTC4 caused a detectable increase in 45Ca2+ uptake only at extracellular Ca2+ concentrations less than 1 mM, and this was again inhibited by PY 108-068 or FPL 55712. It is concluded that the contractile effects of LTC4 in guinea pig taenia coli occur as a consequence of its ability to open voltage-sensitive Ca2+ channels, an effect that may occur independently of membrane depolarization.

Computer model of membrane current and intracellular Ca2+ flux in the isolated guinea pig ventricular myocyte

1994 ◽  
Vol 267 (5) ◽  
pp. 1-1 ◽  
Author(s):  
Charles Nordin
Keyword(s):  
Guinea Pig ◽  
Computer Program ◽  
Computer Model ◽  
Membrane Current ◽  
The Other ◽  
Ventricular Myocyte ◽  
Stimulation Rate ◽  
Intracellular Ca ◽  
Made In

Pages H2117–H2136: Nordin, Charles. “Computer model of membrane current and intracellular Ca2+ flux in the isolated guinea pig ventricular myocyte.” Figure 13: Units of time in Fig. 13B are seconds (not milliseconds). The output for concentration, using the equations of the appendix, is in units of 10−3 mol/l (millimolar). Equation A29 should read (See PDF) Equations A30a and A31a should read (See PDF) Note: All errors in equations, except for the term with asterisk in Eq. A31a and removal of the term (0.1 x iCa) from Eq. A30a, were made in transcribing the computer program to the set of printed equations and therefore do not involve any simulations of the paper. The other changes are refinements of the program that slightly reduce the rise in [Na+]myo and fall in [K+]myo with increasing stimulation rate (Fig. 5A) but do not affect other aspects of the behavior of the model in any significant way.

Sign in / Sign up

Export Citation Format

Share Document