scholarly journals GW26-e2106 The Impact of the Drug Composition Containing Medicine Serum Contains Cassia Twig Liquorice Decoction Components on ICa- L of Guinea Pig Single Ventricular Myocyte

2015 ◽  
Vol 66 (16) ◽  
pp. C23 ◽  
Author(s):  
Yongxia Wang ◽  
Zuoying Xing ◽  
Chulin Zhu ◽  
Yingjie Cao ◽  
Shuangxing Yuan ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Ventricular Myocyte ◽  
The Impact

scholarly journals Novel antibody binding determinants on the capsid surface of serotype O foot-and-mouth disease virus

2014 ◽  
Vol 95 (5) ◽  
pp. 1104-1116 ◽  
Author(s):  
Amin S. Asfor ◽  
Sasmita Upadhyaya ◽  
Nick J. Knowles ◽  
Donald P. King ◽  
David J. Paton ◽  
...  
Keyword(s):  
Amino Acid ◽  
Guinea Pig ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Amino Acid Residues ◽  
Serotype O ◽  
Antigenic Sites ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
The Impact

Five neutralizing antigenic sites have been described for serotype O foot-and-mouth disease viruses (FMDV) based on monoclonal antibody (mAb) escape mutant studies. However, a mutant virus selected to escape neutralization of mAb binding at all five sites was previously shown to confer complete cross-protection with the parental virus in guinea pig challenge studies, suggesting that amino acid residues outside the mAb binding sites contribute to antibody-mediated in vivo neutralization of FMDV. Comparison of the ability of bovine antisera to neutralize a panel of serotype O FMDV identified three novel putative sites at VP2-74, VP2-191 and VP3-85, where amino acid substitutions correlated with changes in sero-reactivity. The impact of these positions was tested using site-directed mutagenesis to effect substitutions at critical amino acid residues within an infectious copy of FMDV O1 Kaufbeuren (O1K). Recovered viruses containing additional mutations at VP2-74 and VP2-191 exhibited greater resistance to neutralization with both O1K guinea pig and O BFS bovine antisera than a virus that was engineered to include only mutations at the five known antigenic sites. The changes at VP2-74 and VP3-85 are adjacent to critical amino acids that define antigenic sites 2 and 4, respectively. However VP2-191 (17 Å away from VP2-72), located at the threefold axis and more distant from previously identified antigenic sites, exhibited the most profound effect. These findings extend our knowledge of the surface features of the FMDV capsid known to elicit neutralizing antibodies, and will improve our strategies for vaccine strain selection and rational vaccine design.

Computer model of membrane current and intracellular Ca2+ flux in the isolated guinea pig ventricular myocyte

1994 ◽  
Vol 267 (5) ◽  
pp. 1-1 ◽  
Author(s):  
Charles Nordin
Keyword(s):  
Guinea Pig ◽  
Computer Program ◽  
Computer Model ◽  
Membrane Current ◽  
The Other ◽  
Ventricular Myocyte ◽  
Stimulation Rate ◽  
Intracellular Ca ◽  
Made In

Pages H2117–H2136: Nordin, Charles. “Computer model of membrane current and intracellular Ca2+ flux in the isolated guinea pig ventricular myocyte.” Figure 13: Units of time in Fig. 13B are seconds (not milliseconds). The output for concentration, using the equations of the appendix, is in units of 10−3 mol/l (millimolar). Equation A29 should read (See PDF) Equations A30a and A31a should read (See PDF) Note: All errors in equations, except for the term with asterisk in Eq. A31a and removal of the term (0.1 x iCa) from Eq. A30a, were made in transcribing the computer program to the set of printed equations and therefore do not involve any simulations of the paper. The other changes are refinements of the program that slightly reduce the rise in [Na+]myo and fall in [K+]myo with increasing stimulation rate (Fig. 5A) but do not affect other aspects of the behavior of the model in any significant way.

scholarly journals The Guinea Pig as a Model for Sporadic Alzheimer’s Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66235 ◽  
Author(s):  
Mathew J. Sharman ◽  
Seyyed H. Moussavi Nik ◽  
Mengqi M. Chen ◽  
Daniel Ong ◽  
Linda Wijaya ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Guinea Pig ◽  
Sporadic Alzheimer’S Disease ◽  
Cholesterol Intake ◽  
The Impact

Impact of parainfluenza-3 virus infection on endothelin receptor density and function in guinea pig airways

2002 ◽  
Vol 103 (s2002) ◽  
pp. 345S-348S ◽  
Author(s):  
Angela C. D'APRILE ◽  
Lynette B. FERNANDES ◽  
Paul J. RIGBY ◽  
Roy G. GOLDIE
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Binding Sites ◽  
Specific Binding ◽  
Tracheal Smooth Muscle ◽  
Receptor Subtypes ◽  
Post Inoculation ◽  
Receptor Density ◽  
And Function ◽  
The Impact

We examined the impact of parainfluenza-3 (P-3) respiratory tract viral infection on the density and function of endothelin (ET) receptor subtypes (ETA and ETB) in guinea pig tracheal smooth muscle. Total specific binding of [125I]ET-1 and the relative proportions of ETA and ETB binding sites for this ligand were assessed at day 0 (control) and at 2, 4, 8 and 16 days post-inoculation. At day 0, the proportions of ETA and ETB binding sites were 30% and 70% respectively. Total specific binding was significantly reduced at day 4 post-inoculation (32% reduction, n = 8–12, P<0.05) and was largely due to a corresponding fall in ETB receptor density at this time point (38% reduction, n = 8–12, P<0.05). The density of ETA receptors also fell significantly at day 8 post-inoculation (33% reduction, n = 6–12, P<0.05). By day 16 post-inoculation, the densities of ETA and ETB receptors had recovered to control values. The ratio of ETA:ETB receptor subtypes did not alter with P-3 infection. While P-3 infection reduced the density of tracheal smooth muscle ETA and ETB receptors, the contractile sensitivity and maximum response to carbachol and ET-1 was not altered in tissue from day 4 post-inoculation compared with the control. There seems to be a significant functional reserve for both receptor subtypes in this species that buffers the impact of P-3 infection on airway smooth muscle responsiveness to ET-1.

scholarly journals Measuring and Modeling Chloride-Hydroxyl Exchange in the Guinea-Pig Ventricular Myocyte

2008 ◽  
Vol 94 (6) ◽  
pp. 2385-2403 ◽  
Author(s):  
S.A. Niederer ◽  
P. Swietach ◽  
D.A. Wilson ◽  
N.P. Smith ◽  
R.D. Vaughan-Jones
Keyword(s):  
Guinea Pig ◽  
Ventricular Myocyte

scholarly journals Determining the impact of form deprived vision on guinea pig ciliary body development

2017 ◽  
Vol 17 (15) ◽  
pp. 35
Author(s):  
Andrew Pucker ◽  
Ashley R. Jackson ◽  
Kirk M. McHugh ◽  
Donald O. Mutti
Keyword(s):  
Guinea Pig ◽  
Ciliary Body ◽  
Body Development ◽  
The Impact
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