3.P.210 The role of protein kinase C on regulation of cytosolic phospholipase A2 in human vascular endothelial cells

1997 ◽  
Vol 134 (1-2) ◽  
pp. 242
Author(s):  
T. Higaki ◽  
S. Sawada ◽  
Y. Kono ◽  
H. Imamura ◽  
Y. Tada ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Phospholipase A2 ◽  
Vascular Endothelial Cells ◽  
Cytosolic Phospholipase A2 ◽  
Vascular Endothelial ◽  
Cytosolic Phospholipase ◽  
Kinase C

scholarly journals Cell Growth Regulation through the Protein Kinase C Pathway in Cultured Human Vascular Endothelial Cells

1993 ◽  
Vol 57 (supplementIV) ◽  
pp. 1207-1210 ◽  
Author(s):  
Chiya Kosaka ◽  
Toshiyuki Sasaguri ◽  
Katsuhiro Zen ◽  
Junichi Masuda ◽  
Kentaro Shimokado ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Growth ◽  
Growth Regulation ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Cell Growth Regulation ◽  
Kinase C

Protein Kinase C-Mediated Inhibition of Cyclin A Expression in Human Vascular Endothelial Cells

1993 ◽  
Vol 193 (3) ◽  
pp. 991-998 ◽  
Author(s):  
C. Kosaka ◽  
T. Sasaguri ◽  
J. Masuda ◽  
K. Zen ◽  
K. Shimokado ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Vascular Endothelial Cells ◽  
Cyclin A ◽  
Vascular Endothelial ◽  
Kinase C

scholarly journals Disturbed flow: p53 SUMOylation in the turnover of endothelial cells

2011 ◽  
Vol 193 (5) ◽  
pp. 805-807 ◽  
Author(s):  
Wakako Takabe ◽  
Noah Alberts-Grill ◽  
Hanjoong Jo
Keyword(s):  
Endothelial Cells ◽  
Blood Flow ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Protein Inhibitor ◽  
Disturbed Flow ◽  
Antiapoptotic Protein ◽  
Kinase C

Disturbed blood flow induces apoptosis of vascular endothelial cells, which causes atherosclerosis. In this issue, Heo et al. (2011. J. Cell Biol. doi:10.1083/jcb.201010051) sheds light on p53’s role in this phenomenon. Disturbed flow induces peroxynitrite production, which activates protein kinase C ζ and it’s binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inhibitor of activated STATy). This leads to p53 SUMOylation and its export to the cytosol, where it binds to the antiapoptotic protein Bcl-2 to induce apoptosis.

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