Disturbed flow: p53 SUMOylation in the turnover of endothelial cells
2011 ◽
Vol 193
(5)
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pp. 805-807
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Keyword(s):
Disturbed blood flow induces apoptosis of vascular endothelial cells, which causes atherosclerosis. In this issue, Heo et al. (2011. J. Cell Biol. doi:10.1083/jcb.201010051) sheds light on p53’s role in this phenomenon. Disturbed flow induces peroxynitrite production, which activates protein kinase C ζ and it’s binding to the E3 SUMO (small ubiquitin-like modifier) ligase PIASy (protein inhibitor of activated STATy). This leads to p53 SUMOylation and its export to the cytosol, where it binds to the antiapoptotic protein Bcl-2 to induce apoptosis.
2013 ◽
Vol 319
(17)
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pp. 2578-2587
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Keyword(s):
1997 ◽
Vol 272
(45)
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pp. 28704-28711
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1993 ◽
Vol 57
(supplementIV)
◽
pp. 1207-1210
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2005 ◽
Vol 2004.17
(0)
◽
pp. 257-258
1994 ◽
Vol 199
(1)
◽
pp. 191-198
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Keyword(s):
1993 ◽
Vol 303
(2)
◽
pp. 260-266
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2020 ◽
Vol 40
(7)
◽
pp. 1748-1762