Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh artery study

2000 ◽  
Vol 150 (1) ◽  
pp. 179-185 ◽  
Author(s):  
F.G.R Fowkes ◽  
A.J Lee ◽  
C.M Hau ◽  
A Cooke ◽  
J.M Connor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Nitric Oxide Synthase ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Methylene Tetrahydrofolate Reductase ◽  
Methylene Tetrahydrofolate ◽  
Peripheral Arterial ◽  
Oxide Synthase

Peripheral arterial disease and intermittent claudication in coronary heart disease patients

2021 ◽  
Vol 322 ◽  
pp. 227-232
Author(s):  
Željko Reiner ◽  
Johan De Sutter ◽  
Lars Ryden ◽  
Erkin Mirrakhimov ◽  
Nana Pogosova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Peripheral Arterial Disease ◽  
Intermittent Claudication ◽  
Arterial Disease ◽  
Peripheral Arterial

Nitric oxide synthase polymorphisms and coronary heart disease

2000 ◽  
Vol 151 (1) ◽  
pp. 124-125
Author(s):  
S. Hevia ◽  
A. Batalla ◽  
R. Alvarez ◽  
G.I. Cubero ◽  
J.J.R. Reguero ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase

scholarly journals Association between physical health and cardiovascular diseases: Effect modification by chronic conditions

2018 ◽  
Vol 6 ◽  
pp. 205031211878533
Author(s):  
Nazmus Saquib ◽  
Robert Brunner ◽  
Manisha Desai ◽  
Matthew Allison ◽  
Lorena Garcia ◽  
...  
Keyword(s):  
Heart Failure ◽  
Coronary Heart Disease ◽  
Congestive Heart Failure ◽  
Heart Disease ◽  
Peripheral Arterial Disease ◽  
Physical Component Summary ◽  
Chronic Conditions ◽  
Arterial Disease ◽  
Physical Component Summary Score ◽  
Peripheral Arterial

Objectives: This study assessed whether the physical component summary score of the RAND-36 health-related quality-of-life survey was associated with incidence of coronary heart disease, stroke, congestive heart failure, angina, or peripheral arterial disease, and whether baseline chronic conditions modified these associations. Methods: Analysis was limited to 69,155 postmenopausal women (50–79 years) in the Women’s Health Initiative Study who had complete data on the RAND-36, the outcomes, and covariates. Chronic conditions were defined as blood pressure ⩾140/90 mm or self-reported heart disease, diabetes, hypertension, arthritis, asthma, emphysema, cancer, and/or cholesterol-reducing medication use. Outcomes data were ascertained during follow-up (1993–2005) with medical records. Results: There were 2451 coronary heart disease, 1896 stroke, 1533 congestive heart failure, 1957 angina, and 502 peripheral arterial disease events during follow-up (median 8.2 years). Participants in the lowest physical component summary quintile, compared to the highest, had a significantly higher risk of developing coronary heart disease (hazard ratio (95% confidence interval) 2.0 (1.7, 2.3)), stroke (1.8 (1.5, 2.2)), angina (2.4(2.0, 2.9)), and peripheral arterial disease (3.0 (2.0, 4.4)), irrespective of chronic conditions. Interactions between physical component summary and existing chronic conditions were not significant for any outcome except congestive heart failure (p = 0.005); after adjustment, participants in the lowest physical component summary quintile and with any chronic condition had nearly a twofold higher risk of congestive heart failure (Yes = 4.4 (3.3, 5.8) vs No = 2.4 (1.2, 4.3)). Conclusion: We found a low physical component summary score was a significant risk factor for individual cardiovascular disease incidence in postmenopausal women.

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