scholarly journals Identification of a DNA-binding site for the transcription factor GC2 in the promoter region of the p12 gene and repression of its positive activity by upstream negative regulatory elements.

1990 ◽  
Vol 265 (35) ◽  
pp. 22035-22043
Author(s):  
S L Guérin ◽  
F Pothier ◽  
S Robidoux ◽  
P Gosselin ◽  
M G Parker
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Binding Site ◽  
Promoter Region ◽  
Regulatory Elements ◽  
Dna Binding Site

scholarly journals One Billion Years of bZIP Transcription Factor Evolution: Conservation and Change in Dimerization and DNA-Binding Site Specificity

2006 ◽  
Vol 24 (3) ◽  
pp. 827-835 ◽  
Author(s):  
G. Amoutzias ◽  
A. Veron ◽  
J Weiner ◽  
M Robinson-Rechavi ◽  
E Bornberg-Bauer ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Binding Site ◽  
Bzip Transcription Factor ◽  
Site Specificity ◽  
Dna Binding Site

scholarly journals Identification of a DNA-binding site for the transcription factor Haa1, required for Saccharomyces cerevisiae response to acetic acid stress

2011 ◽  
Vol 39 (16) ◽  
pp. 6896-6907 ◽  
Author(s):  
Nuno P. Mira ◽  
Sílvia F. Henriques ◽  
Greg Keller ◽  
Miguel C. Teixeira ◽  
Rute G. Matos ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Transcription Factor ◽  
Acetic Acid ◽  
Dna Binding ◽  
Binding Site ◽  
Acid Stress ◽  
Dna Binding Site

scholarly journals t(8;21)(q22;q22) fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression

Blood ◽  
2008 ◽  
Vol 112 (4) ◽  
pp. 1392-1401 ◽  
Author(s):  
Akiko J. Okumura ◽  
Luke F. Peterson ◽  
Fumihiko Okumura ◽  
Anita Boyapati ◽  
Dong-Er Zhang
Keyword(s):  
Gene Expression ◽  
Dna Binding ◽  
Binding Site ◽  
Dna Sequences ◽  
Fusion Proteins ◽  
Target Genes ◽  
Regulatory Elements ◽  
Chromosome Abnormalities ◽  
Cancer Development ◽  
Dna Binding Site

AbstractChromosome abnormalities are frequently associated with cancer development. The 8;21(q22;q22) chromosomal translocation is one of the most common chromosome abnormalities identified in leukemia. It generates fusion proteins between AML1 and ETO. Since AML1 is a well-defined DNA-binding protein, AML1-ETO fusion proteins have been recognized as DNA-binding proteins interacting with the same consensus DNA-binding site as AML1. The alteration of AML1 target gene expression due to the presence of AML1-ETO is related to the development of leukemia. Here, using a 25-bp random double-stranded oligonucleotide library and a polymerase chain reaction (PCR)-based DNA-binding site screen, we show that compared with native AML1, AML1-ETO fusion proteins preferentially bind to DNA sequences with duplicated AML1 consensus sites. This finding is further confirmed by both in vitro and in vivo DNA-protein interaction assays. These results suggest that AML1-ETO fusion proteins have a selective preference for certain AML1 target genes that contain multimerized AML1 consensus sites in their regulatory elements. Such selected regulation provides an important molecular mechanism for the dysregulation of gene expression during cancer development.

scholarly journals DNA binding site preferences and transcriptional activation properties of the Arabidopsis transcription factor GBF1.

1992 ◽  
Vol 11 (4) ◽  
pp. 1275-1289 ◽  
Author(s):  
U. Schindler ◽  
W. Terzaghi ◽  
H. Beckmann ◽  
T. Kadesch ◽  
A.R. Cashmore
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Binding Site ◽  
Transcriptional Activation ◽  
Site Preferences ◽  
Dna Binding Site
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