scholarly journals The long terminal repeat of VL30 retrotransposons contains sequences that determine retinoic acid-induced transcription in cultured keratinocytes.

1993 ◽  
Vol 268 (5) ◽  
pp. 3251-3259
Author(s):  
T.C. Islam ◽  
T.H. Bugge ◽  
S. Bohm
Keyword(s):  
Retinoic Acid ◽  
Long Terminal Repeat ◽  
Terminal Repeat ◽  
Cultured Keratinocytes

Retinoic acid inhibits both the basal activity and phorbol ester-mediated activation of the HIV long terminal repeat promoter

AIDS ◽  
1995 ◽  
Vol 9 (2) ◽  
pp. 129-136
Author(s):  
Greg Towers ◽  
Julian Harris ◽  
Georgina Lang ◽  
Mary K.L. Collins ◽  
David S. Latchman
Keyword(s):  
Retinoic Acid ◽  
Long Terminal Repeat ◽  
Phorbol Ester ◽  
Terminal Repeat ◽  
Long Terminal Repeat Promoter ◽  
Basal Activity

Transcriptional Activation of the Human Immunodeficiency Virus Long Terminal Repeat Sequences by Retinoic Acid in Human Epithelial and Fibroblast Tumor Cell Lines

1996 ◽  
Vol 11 (3) ◽  
pp. 153-158 ◽  
Author(s):  
V. Zoumpourlis ◽  
M. Ergazaki ◽  
D.A. Spandidos
Keyword(s):  
Retinoic Acid ◽  
Tumor Cell ◽  
Long Terminal Repeat ◽  
Cell Lines ◽  
Transcriptional Activation ◽  
Critical Role ◽  
Terminal Repeat ◽  
Tumor Cell Lines ◽  
A Cells ◽  
Hiv 1

We employed a recombinant plasmid, pBHIV1, carrying the long terminal repeat (LTR) sequences of HIV-1 linked to the reporter chloramphenicol acetyl transferase (CAT) gene and to the aminoglycoside phosphotransferase (aph) gene as a selectable marker. We introduced pBHIV1 into human epithelial and fibroblast tumor cell lines (HeLa and MRCSV40TGR), and obtained stable geneticin-resistant HLHIV1-A and SVTGHIV1-A cells, respectively. The response to the retinoic acid was studied on the LTR regulated CAT activity in both cell lines. It was found that retinoic acid at a concentration of 1×10−5 effects a 3.2 - fold increase in CAT expression compared to HIV LTR in HLHIV1-A, but requires a concentration of 5×10−5 M to enhance this expression 4.6-fold in SVTGHIV1-A cells. These data show that retinoic acid may play a critical role in HIV-1 expression in human epithelial and fibroblast cell lines.

Retinoic acid inhibits both the basal activity and phorbol ester-mediated activation of the HIV long terminal repeat promoter

AIDS ◽  
1995 ◽  
Vol 9 (2) ◽  
pp. 129-136 ◽  
Author(s):  
Greg Towers ◽  
Julian Harris ◽  
Georgina Lang ◽  
Mary K.L. Collins ◽  
David S. Latchman
Keyword(s):  
Retinoic Acid ◽  
Long Terminal Repeat ◽  
Phorbol Ester ◽  
Terminal Repeat ◽  
Long Terminal Repeat Promoter ◽  
Basal Activity
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