scholarly journals DIPHOSPHOPYRIDINE NUCLEOTIDE PYROPHOSPHATASE

1948 ◽  
Vol 176 (2) ◽  
pp. 665-677 ◽  
Author(s):  
Arthur Kornberg ◽  
Olov Lindberg
Keyword(s):  
Nucleotide Pyrophosphatase

scholarly journals NUCLEOTIDE PYROPHOSPHATASE

1950 ◽  
Vol 182 (2) ◽  
pp. 763-778 ◽  
Author(s):  
Arthur. Kornberg ◽  
W.E. Pricer
Keyword(s):  
Nucleotide Pyrophosphatase

Comparison of the conformation and stability of the native dimeric, monomelic, tetrameric and the desensitized forms of the nucleotide pyrophosphatase from mung bean (Phaseolus aureus) seedlings

1980 ◽  
Vol 2 (3) ◽  
pp. 211-225 ◽  
Author(s):  
A. R. Venugopala Reddy ◽  
C. V. Balakrishnan ◽  
J. Sobhanaditya ◽  
S. D. Ravindranath ◽  
V. S. Ananthanarayanan ◽  
...  
Keyword(s):  
Mung Bean ◽  
Phaseolus Aureus ◽  
Nucleotide Pyrophosphatase

scholarly journals An Ecto-Nucleotide Pyrophosphatase Is One of the Main Enzymes Involved in the Extracellular Metabolism of ATP in Rat C6 Glioma

1999 ◽  
Vol 72 (2) ◽  
pp. 826-834 ◽  
Author(s):  
Bert Grobben ◽  
Katelijne Anciaux ◽  
Dirk Roymans ◽  
Cristiana Stefan ◽  
Mathieu Bollen ◽  
...  
Keyword(s):  
C6 Glioma ◽  
Nucleotide Pyrophosphatase ◽  
Rat C6 Glioma

scholarly journals The role of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 in diabetic nephropathy

2011 ◽  
Vol 55 (9) ◽  
pp. 677-685 ◽  
Author(s):  
Denise Alves Sortica ◽  
Daisy Crispim ◽  
Guilherme Pozueco Zaffari ◽  
Rogério Friedman ◽  
Luis Henrique Canani
Keyword(s):  
Insulin Resistance ◽  
Diabetic Nephropathy ◽  
Kinase Activity ◽  
Familial Aggregation ◽  
Cell Types ◽  
Chronic Complications ◽  
Nucleotide Pyrophosphatase ◽  
Enpp1 Gene ◽  
Prevalence Of Diabetes Mellitus

The increased prevalence of diabetes mellitus has caused a rise in the occurrence of its chronic complications, such as diabetic nephropathy (DN), which is associated with elevated morbidity and mortality. Familial aggregation studies have demonstrated that besides the known environmental risk factors, DN has a major genetic component. Therefore, it is necessary to identify genes associated with risk for or protection against DN. Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is expressed in several tissues, including the kidneys. Increased levels of ENPP1 expression inhibit tyrosine-kinase activity of the insulin receptor in several cell types, leading to insulin resistance. K121Q polymorphism of the ENPP1 gene seems to be associated with insulin resistance and DN development. The elucidation of genetic factors and their associations will provide better understanding of the pathogenesis of DN and, may consequently, lead to a more effective approach to prevention and treatment.

Cementum and Dentin in Hypophosphatasia

2005 ◽  
Vol 84 (11) ◽  
pp. 1021-1025 ◽  
Author(s):  
T. van den Bos ◽  
G. Handoko ◽  
A. Niehof ◽  
L.M. Ryan ◽  
S.P. Coburn ◽  
...  
Keyword(s):  
Periodontal Ligament ◽  
Inhibitory Action ◽  
Mineral Content ◽  
Deciduous Teeth ◽  
Nucleotide Pyrophosphatase ◽  
Expression Activity ◽  
Activity Of Enzymes

Hypophosphatasia (HPP) often leads to premature loss of deciduous teeth, due to disturbed cementum formation. We addressed the question to what extent cementum and dentin are similarly affected. To this end, we compared teeth from children with HPP with those from matched controls and analyzed them microscopically and chemically. It was observed that both acellular and cellular cementum formation was affected. For dentin, however, no differences in mineral content were recorded. To explain the dissimilar effects on cementum and dentin in HPP, we assessed pyrophosphate (an inhibitor of mineralization) and the expression/activity of enzymes related to pyrophosphate metabolism in both the periodontal ligament and the pulp of normal teeth. Expression of nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) in pulp proved to be significantly lower than in the periodontal ligament. Also, the activity of NPP1 was less in pulp, as was the concentration of pyrophosphate. Our findings suggest that mineralization of dentin is less likely to be under the influence of the inhibitory action of pyrophosphate than mineralization of cementum.

scholarly journals Nucleotide Pyrophosphatase of Tetrahymena pyriformis

Nature ◽  
1967 ◽  
Vol 213 (5071) ◽  
pp. 79-79 ◽  
Author(s):  
GILBERTO G. VILLELA
Keyword(s):  
Tetrahymena Pyriformis ◽  
Nucleotide Pyrophosphatase
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