scholarly journals Upstream sequences confer atrial-specific expression on the human atrial natriuretic factor gene.

1988 ◽  
Vol 263 (19) ◽  
pp. 9075-9078
Author(s):  
M C LaPointe ◽  
J P Wu ◽  
B Greenberg ◽  
D G Gardner
Keyword(s):  
Atrial Natriuretic Factor ◽  
Specific Expression ◽  
Factor Gene ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

Human heart LIM protein activates atrial-natriuretic-factor gene expression by interacting with the cardiac-restricted transcription factor Nkx2.5

2008 ◽  
Vol 409 (3) ◽  
pp. 683-690 ◽  
Author(s):  
Bin Zheng ◽  
Mei Han ◽  
Jin-kun Wen ◽  
Rui Zhang
Keyword(s):  
Transcription Factor ◽  
Atrial Natriuretic Factor ◽  
Human Heart ◽  
Specific Expression ◽  
Human Embryonic Kidney Cells ◽  
Factor Gene ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

hhLIM [human heart LIM (Lin-11/IsI-1/Mec-3) protein] is a muscle-specific LIM-only protein that consists of two LIM motifs. hhLIM functions as a positive regulator for cardiac hypertrophy. Here we report that hhLIM serves as a cofactor regulating the expression of the ANF (atrial natriuretic factor) gene in H9c2 rat cardiomyoblast cells. We found that hhLIM promoted the expression of the ANF gene in H9c2 cells, but not in A293 human embryonic kidney cells. Furthermore, we showed that hhLIM interacted with Nkx2.5 (a cardiac-restricted transcription factor) in vivo and in vitro using its N-terminal LIM domain and enhanced the binding ability of Nkx2.5 to the NKE (Nkx2.5-binding element) boxes in the ANF promoter. These results suggest that hhLIM promotes the specific expression of the ANF gene by co-operating with Nkx2.5.

scholarly journals Proximal regulatory domains of rat atrial natriuretic factor gene.

Circulation ◽  
1991 ◽  
Vol 84 (3) ◽  
pp. 1256-1265 ◽  
Author(s):  
A Rosenzweig ◽  
T D Halazonetis ◽  
J G Seidman ◽  
C E Seidman
Keyword(s):  
Atrial Natriuretic Factor ◽  
Factor Gene ◽  
Regulatory Domains ◽  
Natriuretic Factor ◽  
Atrial Natriuretic
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