Postural effects on pulmonary function and heart rate of preterm infants with lung disease

AbstractSystemic sclerosis (SSc) is a rare connective tissue disease associated with rapid evolving interstitial lung disease (ILD), driving its mortality. Specific biomarkers associated with the progression of this lung disease are highly needed. We aimed to identify specific biomarkers of SSc-ILD to predict the evolution of the disease. For this, we compared prospectively serum levels of several biomarkers associated with lung fibrosis in SSc patients (n = 102), among which SSc-no ILD (n = 63) and SSc-ILD (n = 39), compared to healthy subjects (HS) (n = 39). We also performed a longitudinal study in a subgroup of 28 patients analyzing biomarkers variations and pulmonary function tests over a period of 2 years. Serum level of IGFBP-2 was significantly increased in SSc patients compared to HS, and negatively correlated with pulmonary function (assessed by carbon monoxide transfer coefficient (KCO)) (r = − 0.29, p < 0.01). Two-year longitudinal analysis in a subgroup of 28 SSc patients determined that IGFBP-2 variation was positively correlated with KCO at 2-year follow-up (r = 0.6, p < 0.001). SSc patients with a lower variation of IGFBP-2 (less than 22%) presented significant deterioration of pulmonary function at 2-year follow-up (p < 0.01). ROC curve analysis enabled us to identify that baseline IGFBP-2 > 105 ng/ml was associated with a poor outcome (KCO < 70% predicted) at 2-year follow-up (AUC = 0.75, p < 0.05). We showed for the first time that serum levels of IGFBP-2 might be a prognostic factor of the development of SSc-ILD.

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Antibody Response to Diphtheria-Tetanus-Pertussis Immunization in Preterm Infants Who Receive Dexamethasone for Chronic Lung Disease

PEDIATRICS ◽

10.1542/peds.113.4.733 ◽

2004 ◽

Vol 113 (4) ◽

pp. 733-737 ◽

Cited By ~ 17

Author(s):

M. J. Robinson ◽

C. Heal ◽

E. Gardener ◽

P. Powell ◽

D. G. Sims

Keyword(s):

Antibody Response ◽

Lung Disease ◽

Preterm Infants ◽

Chronic Lung Disease

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Follow-up at 15 Years of Preterm Infants From a Controlled Trial of Moderately Early Dexamethasone for the Prevention of Chronic Lung Disease

PEDIATRICS ◽

10.1542/peds.2004-0956 ◽

2005 ◽

Vol 115 (3) ◽

pp. 681-687 ◽

Cited By ~ 34

Author(s):

S. J. Gross

Keyword(s):

Lung Disease ◽

Preterm Infants ◽

Chronic Lung Disease ◽

Controlled Trial

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Myocardial Infarction Injury in Patients with Chronic Lung Disease Entering Pulmonary Rehabilitation: Frequency and Association with Heart Rate Parameters

PM&R ◽

10.1016/j.pmrj.2018.03.005 ◽

2018 ◽

Vol 10 (9) ◽

pp. 917-925

Author(s):

Carmen A. Sima ◽

Benny C. Lau ◽

Carolyn M. Taylor ◽

Stephan F. van Eeden ◽

W. Darlene Reid ◽

...

Keyword(s):

Myocardial Infarction ◽

Heart Rate ◽

Lung Disease ◽

Chronic Lung Disease ◽

Pulmonary Rehabilitation

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Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease

Canadian Respiratory Journal ◽

10.1155/2018/3640967 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Kazushige Shiraishi ◽

Torahiko Jinta ◽

Naoki Nishimura ◽

Hiroshi Nakaoka ◽

Ryosuke Tsugitomi ◽

...

Keyword(s):

Interstitial Lung Disease ◽

Pulmonary Function ◽

Lung Disease ◽

Clinical Data ◽

Diffusing Capacity ◽

Partial Pressure Of Oxygen ◽

Digital Clubbing ◽

Common Presentation ◽

Arterial Blood ◽

Lower Oxygen

Background. Although digital clubbing is a common presentation in patients with interstitial lung disease (ILD), little has been reported regarding its role in assessing patients with ILD. This study evaluated patients with ILD for the presence of clubbing and investigated its association with clinical data. Methods. We evaluated patients with ILD who visited the teaching hospital at which the study was conducted, between October 2014 and January 2015. Clubbing, evaluated using a Vernier caliper for individual patients, was defined as a phalangeal depth ratio > 1. We examined the association of clubbing with clinical data. Results. Of 102 patients with ILD, we identified 17 (16.7%) with clubbing. The partial pressure of oxygen in arterial blood was lower (65.2 ± 5.9 mmHg versus 80.2 ± 3.1 mmHg; p=0.03), serum Krebs von den Lugen-6 (KL-6) levels were higher (1495.0 ± 277.4 U/mL versus 839.1 ± 70.2 U/mL; p=0.001), and the percent predicted diffusing capacity of carbon monoxide was lower (50.0 ± 6.0 versus 73.5 ± 3.1; p=0.002) in these patients with clubbing. Conclusions. Patients with clubbing had lower oxygen levels, higher serum KL-6 levels, and lower pulmonary function than those without clubbing.

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In preterm infants, is there randomized controlled trial evidence to support the use of salbutamol for preventing chronic lung disease?

Cochrane Clinical Answers ◽

10.1002/cca.687 ◽

2015 ◽

Keyword(s):

Randomized Controlled Trial ◽

Lung Disease ◽

Preterm Infants ◽

Chronic Lung Disease ◽

Controlled Trial ◽

Randomized Controlled ◽

Trial Evidence

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Transcutaneous Oxygen Tension During Nonnutritive Sucking in Preterm Infants

PEDIATRICS ◽

10.1542/peds.74.4.539 ◽

1984 ◽

Vol 74 (4) ◽

pp. 539-542

Author(s):

Roberto Paludetto ◽

Steven S. Robertson ◽

Maureen Hack ◽

Chandra R. Shivpuri ◽

Richard J. Martin

Keyword(s):

Heart Rate ◽

Respiratory Rate ◽

Preterm Infants ◽

Oxygen Tension ◽

Sleep State ◽

Transcutaneous Oxygen Tension ◽

Transcutaneous Oxygen ◽

Beneficial Effects ◽

Nonnutritive Sucking ◽

Postconceptional Age

The effects of nonnutritive sucking on transcutaneous oxygen tension, heart rate, and respiratory rate were studied sequentially in 14 sleeping preterm infants breathing room air. Transcutaneous oxygen tension increased during nonnutritive sucking in infants between 32 and 35 weeks postconceptional age, but not in those between 36 and 39 weeks. This response was not associated with a change in respiratory rate or sleep state, although heart rate tended to increase. These data offer further support for the beneficial effects of nonnutritive sucking in preterm infants.

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