Use of dichromatic ear densitometry to evaluate kinetics of indocyanine green (ICG) removal in children with liver disease

Purpose. Paired-agent molecular imaging methods, which employ coadministration of an untargeted, “control” imaging agent with a targeted agent to correct for nonspecific uptake, have been demonstrated to detect 200 cancer cells in a mouse model of metastatic breast cancer. This study demonstrates that indocyanine green (ICG), which is approved for human use, is an ideal control agent for future paired-agent studies to facilitate eventual clinical translation. Methods. The kinetics of ICG were compared with a known ideal control imaging agent, IRDye-700DX-labeled antibody in both healthy and metastatic rat popliteal lymph nodes after coadministration, intradermally in the footpad. Results. The kinetics of ICG and antibody-based imaging agent in tumor-free rat lymph nodes demonstrated a strong correlation with each other (r = 0.98, p<0.001) with a measured binding potential of −0.102 ± 0.03 at 20 min postagent injection, while the kinetics of ICG and targeted imaging agent shows significant separation in the metastatic lymph nodes. Conclusion. This study indicated a potential for microscopic sensitivity to cancer spread in sentinel lymph nodes using ICG as a control agent for antibody-based molecular imaging assays.

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Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image‐guided oral cancer surgery applications

Head & Neck ◽

10.1002/hed.25541 ◽

2018 ◽

Vol 41 (4) ◽

pp. 1032-1038 ◽

Cited By ~ 5

Author(s):

Yuxin Wang ◽

Diya Xie ◽

Ziyang Wang ◽

Xudong Zhang ◽

Qian Zhang ◽

...

Keyword(s):

Oral Cancer ◽

Indocyanine Green ◽

Normal Tissue ◽

Cancer Surgery ◽

Image Guided ◽

Tissue Fluorescence ◽

Kinetics Of

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ASTEMIZOLE DOESN’T APPEAR TO AFFECT KINETICS OF INDOCYANINE GREEN

InPharma ◽

10.1007/bf03304144 ◽

1983 ◽

Vol 409 (1) ◽

pp. 15-15

Keyword(s):

Indocyanine Green ◽

Kinetics Of

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Studies of human zinc kinetics using the stable isotope 70Zn

Clinical Science ◽

10.1042/cs0840113 ◽

1993 ◽

Vol 84 (1) ◽

pp. 113-117 ◽

Cited By ~ 34

Author(s):

N. M. Lowe ◽

A. Green ◽

J. M. Rhodes ◽

M. Lombard ◽

R. Jalan ◽

...

Keyword(s):

Liver Disease ◽

Alcoholic Liver Disease ◽

Turnover Rate ◽

Kinetic Studies ◽

Normal Subjects ◽

Short Term ◽

Control Subjects ◽

Two Component ◽

Kinetics Of ◽

Fractional Turnover

1. The short-term (120 min) kinetics of Zn turnover has been studied in control subjects and patients with alcoholic liver disease after intravenous injection of 0.5 mg of 96.5% enriched 70ZnCl2. 2. The 70Zn enrichment of plasma was found closely to obey two-compartment kinetics and the derived two-component decay equation has been used to calculate the size and turnover of the initial two rapidly exchanging pools of body Zn. 3. In normal subjects isotopic Zn appears initially to equilibrate with the whole of the plasma Zn which comprises the first metabolic compartment, pool a. This has a size of 0.72 ± 0.1 μmol/kg. 70Zn equilibration then occurs with a second compartment, pool b, consistent with a rapidly exchanging liver Zn pool of size 3.60 ± 0.93 μmol/kg. The fractional turnover rate of pool b was found to be fivefold slower than that of pool a. 4. In the alcoholic group an expansion of pool a was observed (1.63 ± 0.39 μmol/kg), but the size of the second pool was not significantly different from that of control subjects (5.55 ± 1.0 μmol/kg), although its fractional turnover was significantly increased (Kab: control subjects, 0.018 ± 0.002 min−1, alcoholic patients, 0.031 ± 0.006 min−1). 5. These data therefore demonstrate that kinetic studies using stable isotopes of Zn can provide novel information on exchangeable Zn pools in man, but provide no support for the possibility of an underlying Zn depletion in patients with alcoholic liver disease.

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